Soccer schedules in Europe: an overview

In this paper, we give an overview of the competition formats and the schedules used in 25 European soccer competitions for the season 2008?C2009. We discuss how competitions decide the league champion, qualification for European tournaments, and relegation. Following Griggs and Rosa (Bull. ICA 18:65?C68, 1996), we examine the popularity of the so-called canonical schedule. We investigate the presence of a number of properties related to successive home or successive away matches (breaks) and of symmetry between the various parts of the competition. We introduce the concept of ranking-balancedness, which is particularly useful to decide whether a fair ranking can be made. We also determine how the schedules manage the carry-over effect. We conclude by observing that there is quite some diversity in European soccer schedules, and that current schedules leave room for further optimizing.     

All normalized anti-monotonic overlap graph measures are bounded

In graph mining, a frequency measure for graphs is anti-monotonic if the frequency of a pattern never exceeds the frequency of a subpattern. The efficiency and correctness of most graph pattern miners relies critically on this property. We study the case where frequent subgraphs have to be found in one graph. Vanetik et al. (Data Min Knowl Disc 13(2):243?C260, 2006) already gave sufficient and necessary conditions for anti-monotonicity of graph measures depending only on the edge-overlaps between the instances of the pattern in a labeled graph. We extend these results to homomorphisms, isomorphisms and homeomorphisms on both labeled and unlabeled, directed and undirected graphs, for vertex- and edge-overlap. We show a set of reductions between the different morphisms that preserve overlap. As a secondary contribution, we prove that the popular maximum independent set measure assigns the minimal possible normalized frequency and we introduce a new measure based on the minimum clique partition that assigns the maximum possible normalized frequency. In that way, we obtain that all normalized anti-monotonic overlap graph measures are bounded from above and below. We also introduce a new measure sandwiched between the former two based on the polynomial time computable Lovász ??-function.     

Remote Attestation on Legacy Operating Systems With Trusted Platform Modules

A lot of progress has been made to secure network communication, e.g., through the use of cryptographic algorithms. However, this offers only a partial solution as long as the communicating end points still suffer from security problems. A number of applications require remote verification of software executing on an untrusted platform. Trusted computing solutions propose to solve this problem through software and hardware changes, typically a secure operating system and the addition of a secure coprocessor respectively. On the other hand, timed execution of code checksum calculations aims for a solution on legacy platforms, but can not provide strong security assurance. We present a mixed solution by using the trusted computing hardware, namely the time stamping functionality of the trusted platform module, in combination with a timing based remote code integrity verification mechanism. In this way, we do not require a secure operating system, but at the same time the overall security of the timed execution scheme can be improved.     

Managing value-at-risk for a bond using bond put options

This paper studies a strategy that minimizes the Value-at-Risk (VaR) of a position in a zero-coupon bond by buying a percentage of a put option, subject to a fixed budget available for hedging. We elaborate a formula for determining the optimal strike price for this put option in case of a Vasicek stochastic interest rate model. We demonstrate the relevance of searching the optimal strike price, since moving away from the optimum implies a loss, either due to an increased VaR or due to an increased hedging expenditure. In this way, we extend the results of [Ahn, Boudoukh, Richardson, and Whitelaw (1999). Journal of Finance, 54, 359–375] who minimize VaR for a position in a share. In addition, we look at the alternative risk measure Tail Value-at-Risk.     

Microbial nitrogen dynamics in south central Chilean agricultural and forest ecosystems located on an Andisol

The natural soil N supply in volcanic soils (Andisols) can be a significant source of plant-available N for agro-ecosystems. Nevertheless, intensive farming systems in south Chile apply high fertilization rates, which lead to high production costs and involve a risk for adverse ecosystem effects. In order to achieve sustainable land management, a better understanding of the processes that govern soil N availability and loss, and their external drivers, is required. In this study, we selected a winter-cropland, a summer crop-winter fallow rotation, and a forest, used as a reference ecosystem. Gross N transformations (¹⁵N isotope dilution) and microbial community structure (phospho-lipid fatty acid analysis) in the topsoil were determined. Gross N mineralization was about ten times lower in the agro-ecosystems than in the forest, while gross nitrification was low in all sites. Gross N immobilization equalized or exceeded the gross inorganic N production in all sites. Microbial biomass was 3–5 times more abundant in the forest than in the agro-ecosystems. A positive relationship between the ratio fungi/bacteria and total microbial biomass was observed in these Andisols. We suggest that the reduction in fungal biomass induced a lower extracellular enzyme production and limited soil organic matter depolymerisation in the agro-ecosystems. We conclude that soil N cycling was unable to provide a significant N input for the croplands, but also the risk for ecosystem N losses was low, even under fallow soil conditions. Current fertilization practices appropriately anticipated the soil N cycling processes, but further research should indicate the potential of alternative land management to reduce fertilizer cost.     

Molecular markers of hemostatic activation and inflammation following major injury: effect of therapy with IFN-gamma

The aim of this study was to develop a simple, reliable, and inexpensive in-house system for routine species identification of staphylococci in clinical practice. The system combines 15 key tests (including carbohydrate fermentation) performed in micro-well strips and antimicrobial disk diffusion susceptibility tests performed on standardised paper disk method antibiotic sensitivity medium agar. Twenty-eight staphylococcal reference strains belonging to 18 different species were correctly identified using this in-house system. A total of 291 clinical staphylococci isolates were evaluated with the in-house system and a conventional identification scheme. The in-house system identified 281 (96.6%) of these 291 isolates. Eleven different species were recognised. The five species most frequently identified were Staphylococcus epidermidis (48.6%), Staphylococcus aureus (27.8%), Staphylococcus haemolyticus (8.2%), Staphylococcus hominis (5.7%), and Staphylococcus warneri (5.3%). There was an agreement of 86.3% between the species identification obtained with the in-house system and the conventional identification scheme. All coagulase-negative isolates initially identified as species other than Staphylococcus epidermidis as well as indistinctly identified isolates were also evaluated with a commercial identification system. The agreement between species identification obtained with the in-house system and the commercial system for 101 identified isolates was 73%. Several isolates that were difficult to distinguish with the conventional scheme and/or the commercial system were identified with the aid of the antimicrobial susceptibility test included in the in-house system. The described test scheme should be of value for identification of clinically significant staphylococci species.     

Lutheran antigens, CD44-related antigens, and Lutheran regulatory genes

The Lutheran (Lu) blood group antigens are a family of human erythrocyte antigens which reside on two closely-related erythrocyte integral membrane proteins. Sixteen Lutheran or so-called para-Lutheran antigens have thus far been described, and human antisera to many of them have been shown to immunoblot two proteins, of 78 and 85 kDa. Lu cDNA encodes an integral membrane protein of 597 amino acids that is a member of the Ig superfamily. Lu proteins comprise five Ig superfamily domains, along with a single transmembrane domain and a cytoplasmic domain of about 60 amino acids. The two proteins seen in biochemical studies of red cell membranes appear to be derived from 2 mRNA species that differ only in their 3' ends, suggesting that they arise from alternate splicing of a single preRNA. Three genetic backgrounds for the Lu(a-b-) [Lu null] phenotype have been described. A recessive Lu null phenotype is rarely observed as a result of homozygosity for two amorphic LU alleles. However, the most common Lu(a-b-) phenotype appears to be caused by an independently segregating, dominant gene, designated In (Lu), which inhibits expression of all Lutheran antigens to nearly undetectable levels. This gene also affects the expression of other cell surface proteins and blood group antigens that are genetically unlinked to the Lutheran locus, including CD44 and MER2. CD44, a member of the cartilage link family of proteins, bears the In and AnWj blood group antigens. A widely distributed protein CD44 is expressed at normal levels on all tissues except erythrocytes in the presence of the In (Lu) gene. A second Lutheran regulatory gene, XS2, is responsible for the third Lu(a-b-) phenotype, which exhibits an X-linked inheritance pattern. The XS2 gene down-regulates but does not abolish expression of LU genes and does not affect expression of CD44.