MRI-based Sensors for In Vivo Imaging of Metal Ions in Biology

Although much is known about the diverse roles of metal ions in biology, most of the acquired knowledge was obtained with fluorescent dyes or electrophysiological approaches. However, the ability to non-invasively monitor variation in metal ions and to assess their physiological distribution in health and disease is very limited. Recent advances in the field of molecular magnetic resonance imaging (MRI) have offered new capabilities through the design and development of MRI-responsive sensors for a wide range of applications, including the ability to sense and spatially map metal ions. Here, we briefly summarize the recent progress in the development and performance of MRI sensors designed to monitor metal ions in biology while emphasizing their in vivo uses, their limitations, and remaining challenges. Among the proposed MRI-sensors, Zn²⁺ and Ca²⁺ responsive agents are those that have already been used in live intact subjects, and therefore, these will be emphasized here.     

Grammatical awareness in the spoken and written language of language-disabled children.

Two experiments examined judgment, revision, and error-identification deficits in relation to expressive language skills and morphemic errors in writing. 12 language-disabled (LND) children (aged 8 yrs 2 mo to 12 yrs 4 mo) and 11 controls (aged 6 yrs 3 mo to 6 yrs 11 mo) matched for language ability participated in Exp 1. 11 LND children (aged 9 yrs 1 mo to 12 yrs 2 mo), 11 age-matched children with no language disability, and 11 children (aged 6 yrs 2 mo to 8 yrs 0 mo) matched to LND Ss for language ability participated in Exp 2. LND Ss who did not lack expressive use of target morphemes also did not differ from language-matched Ss in their ability to (1) judge the grammaticality of spoken sentences, (2) revise them, and (3) identify errors. (French abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The methodologies of hazardous materials transportation risk assessment

Intense interest now exists in the potential of risk assessment as an aid to public and private decision making on hazardous activities. Inadequacies in its methodologies and supporting data have nevertheless so far limited its efficacy in practice. Among attacks on the problem of improving this efficacy is a project supported by the National Science Foundation which identifies and focuses on improvements in particular areas of uncertainty in risk assessment methodologies. This paper presents some of the project's material that pertains to hazardous materials transportation. It overviews the general risk assessment problem, presents a structured review of the types of methodologies employed in estimating the contribution to risk of the different phases of a hazardous material incident, and then reviews the procedures available for the evaluation of the significance of the risks estimated, and of potential means for their mitigation. Comments are made throughout, and in the paper's conclusions, on the problems arising in these estimation and evaluation processes, and on general approaches to their resolution.