Collective Thomson scattering of a high power electron cyclotron resonance heating beam in LHD (invited)

Collective Thomson scattering (CTS) system has been constructed at LHD making use of the high power electron cyclotron resonance heating (ECRH) system in Large Helical Device (LHD). The necessary features for CTS, high power probing beams and receiving beams, both with well defined Gaussian profile and with the fine controllability, are endowed in the ECRH system. The 32 channel radiometer with sharp notch filter at the front end is attached to the ECRH system transmission line as a CTS receiver. The validation of the CTS signal is performed by scanning the scattering volume. A new method to separate the CTS signal from background electron cyclotron emission is developed and applied to derive the bulk and high energy ion components for several combinations of neutral beam heated plasmas.     

Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs

Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two-thirds of promising new chemical entities failing to enter a clinical setting due to solubility issues. Although oral formulations have made some impact, alternative enhancement strategies for administration of such molecules are actively sought. Over the last decade, innovation on a global scale has enabled the expansion of the frontiers of microarray patches (MAPs) further than ever before. Initially designed to load low doses of hydrophilic and potent therapeutic agents, MAPs are now becoming a viable strategy for the immediate and long-acting delivery of poorly soluble drugs through the skin. This together with the advantages of transdermal administration over the oral and parenteral routes, make of MAPs an appealing platform for the development of products with increased patient compliance. Undoubtedly, MAPs will soon become a readily available therapeutic alternative, and experts from academia, industry and regulatory bodies are working together aiming to facilitate the progression of MAPs toward safe and effective clinical use. This review aims to highlight the ability of MAPs to deliver poorly soluble actives, discuss the mechanisms behind in-skin drug absorption, and evaluate the future direction of the field.     

Endwall convective heat transfer for bluff bodies

The endwall heat transfer characteristics of forced flow past bluff bodies have been investigated using liquid crystal thermography (LCT). The bluff body is placed in a rectangular channel with both its ends attached to the endwalls. The Reynolds number varies from 50,000 to 100,000. In this study, a single bluff body and two bluff bodies arranged in tandem are considered. Due to the formation of horseshoe vortices, the heat transfer is enhanced appreciably for both cases. However, for the case of two bluff bodies in tandem, it is found that the presence of the second bluff body decreases the heat transfer as compared to the case of a single bluff body. In addition, the results show that the heat transfer exhibits Reynolds number similarity. For a single bluff body, the Nusselt number profiles collapse well when the data are scaled by Re^0.55; for two bluff bodies arranged in tandem, the heat transfer scaling is changed to Re^0.51, indicating that the power index of Reynolds number is flow dependent.     

Enzymatic formation of styrene during wheat beer fermentation is dependent on pitching rate and cinnamic acid content

Styrene is formed by the thermal decarboxylation of cinnamic acid during wort boiling or by enzymatic decarboxylation during fermentation. The enzymatic reaction processes simultaneously to the decarboxylation of ferulic‐ and p‐cumaric acid to clove‐like 4‐vinylguaiacol and phenolic 4‐vinylphenol by the same PAD1 and FDC1 decarboxylase enzymes. However, the formation of styrene occurs much faster within the first hours of fermentation. In addition, the conversion of cinnamic acid starts immediately after pitching without an adaption of yeast on the new medium. Only after 120 min does the level of transposition decrease. Moreover, high cinnamic acid content in pitching wort, in combination with an open fermentation management, causes faster and higher styrene formation during this period. In contrast to the formation of 4‐vinylguaiacol, a correlation between pitching rate and styrene formation during open fermentation could be shown. The resulting time interval between styrene and 4‐vinylguaiacol formation provides scope for minimization strategies for styrene, while maintaining the typical wheat beer flavours. Copyright © 2012 The Institute of Brewing & Distilling     

Design and performance of the collective Thomson scattering receiver at ASDEX Upgrade

Here we present the design of the fast-ion collective Thomson scattering receiver for millimeter wave radiation installed at ASDEX Upgrade, a tokamak for fusion plasma experiments. The receiver can detect spectral power densities of a few eV against the electron cyclotron emission background on the order of 100 eV under presence of gyrotron stray radiation that is several orders of magnitude stronger than the signal to be detected. The receiver down converts the frequencies of scattered radiation (100-110 GHz) to intermediate frequencies (IF) (4.5-14.5 GHz) by heterodyning. The IF signal is divided into 50 IF channels tightly spaced in frequency space. The channels are terminated by square-law detector diodes that convert the signal power into DC voltages. We present measurements of the transmission characteristics and performance of the main receiver components operating at mm-wave frequencies (notch, bandpass, and lowpass filters, a voltage-controlled variable attenuator, and an isolator), the down-converter unit, and the IF components (amplifiers, bandpass filters, and detector diodes). Furthermore, we determine the performance of the receiver as a unit through spectral response measurements and find reasonable agreement with the expectation based on the individual component measurements.     

Collective Thomson scattering measurements with high frequency resolution at TEXTOR

We discuss the development and first results of a receiver system for the collective Thomson scattering (CTS) diagnostic at TEXTOR with frequency resolution in the megahertz range or better. The improved frequency resolution expands the diagnostic range and utility of CTS measurements in general and is a prerequisite for measurements of ion Bernstein wave signatures in CTS spectra. The first results from the new acquisition system are shown to be consistent with theory and with simultaneous measurements by the standard receiver system.     

Development of novel fuel ion ratio diagnostic techniques

To overcome the challenge of measuring the fuel ion ratio in the core (ρ<0.3) of ITER, a coordinated effort aiming at developing diagnostic techniques has been initiated. The investigated techniques are novel uses or further development of existing methods such as charge exchange recombination spectrometry, neutron spectrometry, and collective Thomson scattering. An overview of the work on the three diagnostic techniques is presented.     

Waveguide Bandpass Filters for Millimeter-Wave Radiometers

A fundamental requirement for most mm-wave heterodyne receivers is the rejection of the input image signal which is located close to the local oscillator frequency. For this purpose we use a bandpass filter, which for heterodyne receivers is also called an image rejection filter. In this paper we present a systematic approach to the design of a waveguide bandpass filter with a passband from 100 to 110 GHz and upper rejection bandwidth in the range from 113 to 145 GHz. We consider two non-tunable filter configurations: the first one is relatively selective with 11 sections (poles) whereas the second one is simpler with 5 sections. We used established design equations to propose an initial guess for the geometries of the filters, optimized the geometries, constructed the filters using two different milling methods, measured their transmission and reflection characteristics, and compared the measurements with numerical simulations. Measurements of both filters agree well with simulations in frequency response and rejection bandwidth. The insertion loss of the 11-pole filter is better than 10 dB and that of the 5-pole filter is better than 5 dB. The 11-pole filter has a sharper attenuation roll-off compared with the 5-pole filter. The upper out-of-band rejection is better than 40 dB up to 145 GHz for the 11-pole filter and up to 155 GHz for the 5-pole filter.     

Prüffeldorientierte Zuordnung von Prüfern für die operative Personaleinsatzplanung in Wirtschaftsprüfungsgesellschaften

Zusammenfassung Basierend auf den Ergebnissen einer empirischen Untersuchung wurde ein hierarchischer Ansatz zur Personaleinsatzplanung in Wirtschaftsprüfungsgesellschaften entwickelt, der die Teilprobleme der taktischen, der taktisch-operativen und der operativen Planung umfaßt. Der vorliegende Beitrag setzt sich mit der operativen Planung auseinander. Das Problem wird zunächst als binäres Optimierungsproblem formuliert. Anschließend wird ein speziell an die Problemstruktur angepaßtes heuristisches Verfahrensschema vorgestellt, das unter Verwendung von Prioritätswerten randomisierte Auswahlentscheidungen trifft. Die Eignung des Verfahrensschemas wird in einer umfangreichen experimentellen Untersuchung nachgewiesen.