Beam test of the CsI(Tl) calorimeter for the BELLE detector at the KEK-B factory

We studied the performance of a prototype electromagnetic calorimeter for the BELLE detector at the KEK proton synchrotron for an energy range of 0.25–3.5 GeV. The prototype consisted of an array of 6 × 5 CsI(Tl) crystals with 30 cm length (16.2 radiation lengths) and about 6 cm × 6 cm cross section. The scintillation light of each CsI(Tl) crystal was read out by two large-area PIN photodiodes and charge-sensitive preamplifiers attached at the rear face of the crystal. We measured the energy and position resolution for electrons and the e/π separation for two sets of matrix configurations: one corresponded to the center and the other to the edge of the barrel calorimeter. The overall performance measured by the test proves that the prototype calorimeter is satisfactory for the use in the BELLE detector.     

Mesa-isolated GaAs Schottky-barrier photodiodes

The design, fabrication and characterisation of GaAs Schottky-barrier photodiodes with evaporated, free-standing-metal airbridges is reported. The photodiodes were fabricated using all dry-etching techniques. Anisotropic chemically assisted ion beam etching was used to etch vertical sidewall mesas, and isotropic reactive ion etching was used to etch a lateral tunnel. A free-standing-metal airbridge created by the lateral tunnel etch results in isolation of the active area at the same time providing free-standing-metal interconnection to the contact pad.<>     

Cross-specialty linkage and extrapolation of resource-based relative value scales

We used the fluorescent labelled dopamine D1-receptor antagonist Bodipy-SCH 23390 for the cellular localization of D1-ligand binding sites in the retinae of different vertebrates (teleosts, Xenopus, turtle, rat and rabbit). Competition experiments with unfixed cryosections of fish retina were performed to characterize the binding conditions of Bodipy-labelled SCH 23390. Tissue bound [3H]SCH 23390 was displaceable with increased amounts of bodipy-SCH 23390. The pharmacological specificity of the D1 fluorescent antagonist was determined by competition experiments with an excess of unlabelled SCH 23390. This treatment significantly reduced the level of fluorescence of the retina confirming the specificity of the binding. We observed a homogeneously distributed fluorescence signal in both plexiform layers in unfixed cryosections of fish, frog, turtle, rat and rabbit. Similar staining intensities of both plexiform layers were found in frog, turtle, rat and rabbit retina. In teleosts, the label of the outer plexiform layer was markedly more intense. Non-specific label was associated with photoreceptor outer and inner segments. The specific labelling of both plexiform layers indicates a mismatch of dopamine releasing and D1-binding sites, and suggests a possible extrasynaptic localization of the D1-receptor. The physiological significance of the observed distribution of D1-ligand binding sites is discussed with respect to the role of dopamine in controlling adaptational processes in the retina.     

CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer

There is an urgent need for identification of new prognostic markers and therapeutic targets for non-small cell lung cancer (NSCLC). In this study, we evaluated immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis revealed no prognostic value for the markers studied, except CD163 and CD206. At the same time, macrophage markers iNOS and CHID1 were found to be expressed in tumor cells and associated with prognosis. We showed that high iNOS expression is a marker of favorable prognosis for squamous cell lung carcinoma (SCC), and NSCLC in general. Similarly, high CHID1 expression is a marker of good prognosis in adenocarcinoma and in NSCLC in general. Analysis of prognostic significance of a high CHID1/iNOS expression combination showed favorable prognosis with 20 months overall survival of patients from the low CHID1/iNOS expression group. For the first time, we demonstrated that CHID1 can be expressed by NSCLC cells and its high expression is a marker of good prognosis for adenocarcinoma and NSCLC in general. At the same time, high expression of iNOS in tumor cells is a marker of good prognosis in SCC. When used in combination, CHID1 and iNOS show a very good prognostic capacity for NSCLC. We suggest that in the case of lung cancer, tumor-associated macrophages are likely ineffective as a therapeutic target. At the same time, macrophage markers expressed by tumor cells may be considered as targets for anti-tumor therapy or, as in the case of CHID1, as potential anti-tumor agents.     

Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade

In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE₂) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.     

Exploring the Relationship Between Green Consumption Value,Satisfaction, and Loyalty to Hybrid Car in Elderly Consumers

The study aimed to examine the relationship between green consumption value, satisfaction, and loyalty of driving hybrid cars among elderly consumers. Data were collected from a cross‐sectional survey of 314 elderly consumers who purchased hybrid cars in the United States. A partial least squares analysis revealed that elderly consumers’ social, price, and quality values positively influenced the satisfaction of their hybrid car experience, and their satisfaction significantly influenced their loyalty of hybrid car. The relationship between green consumption value, satisfaction, and loyalty toward driving hybrid cars among elderly consumers revealed insight into their value orientations toward the hybrid car. Special efforts are suggested in promoting hybrid car use to elderly consumer groups. Marketers should pay attention to changing beliefs and increasing perceived values of driving a hybrid car for consumers to encourage them to use green products.     

Central Aggregator Intrusion Detection System for Denial of Service Attacks

Vehicle-to-grid technology is an emerging field that allows unused power from Electric Vehicles (EVs) to be used by the smart grid through the central aggregator. Since the central aggregator is connected to the smart grid through a wireless network, it is prone to cyber-attacks that can be detected and mitigated using an intrusion detection system. However, existing intrusion detection systems cannot be used in the vehicle-to-grid network because of the special requirements and characteristics of the vehicle-to-grid network. In this paper, the effect of denial-of-service attacks of malicious electric vehicles on the central aggregator of the vehicle-to-grid network is investigated and an intrusion detection system for the vehicle-to-grid network is proposed. The proposed system, central aggregator–intrusion detection system (CA-IDS), works as a security gateway for EVs to analyze and monitor incoming traffic for possible DoS attacks. EVs are registered with a Central Aggregator (CAG) to exchange authenticated messages, and malicious EVs are added to a blacklist for violating a set of predefined policies to limit their interaction with the CAG. A denial of service (DoS) attack is simulated at CAG in a vehicle-to-grid (V2G) network manipulating various network parameters such as transmission overhead, receiving capacity of destination, average packet size, and channel availability. The proposed system is compared with existing intrusion detection systems using different parameters such as throughput, jitter, and accuracy. The analysis shows that the proposed system has a higher throughput, lower jitter, and higher accuracy as compared to the existing schemes.     

A 2‐in. a‐Si:H TFT‐LCD with embedded backlight control TFT sensors with various channel widths

Abstract— A 2.0‐in. a‐Si:H TFT‐LCD with embedded TFT sensors for the control of the backlight intensity according to the ambient light intensity has been developed. Two types of a‐Si:H TFT sensors with various channel widths were embedded into a TFT backplane with bottom‐ and top‐gate structures for measuring the ambient light and backlight illumination, respectively. The output signal, measured by a readout IC, increased with backlight intensity until 20,000 lux.     

Two methods for the calculation of the degree of an approximate greatest common divisor of two inexact polynomials

The calculation of the degree d of an approximate greatest common divisor of two inexact polynomials f(y) and g(y) reduces to the determination of the rank loss of a resultant matrix, the entries of which are functions of the coefficients of f(y) and g(y). This paper considers this issue by describing two methods to calculate d, such that knowledge of the noise level imposed on the coefficients of f(y) and g(y) is not assumed. One method uses the residual of a linear algebraic equation whose coefficient matrix and right hand side vector are derived from the Sylvester resultant matrix S(f,g), and the other method uses the first principal angle between a line and a hyperplane, the equations of which are calculated from S(f,g). Computational results on inexact polynomials whose exact forms have multiple roots of high degree are shown and very good results are obtained. These results are compared with the rank loss of S(f,g) for the calculation of d, and it is shown that this method yields incorrect results for these examples.