A facile sol–gel procedure has been developed for the synthesis of colloidal alumina nanocrystals. For the first time, optical characterization procedures were employed to study the quantum confinement effects in optical properties of the prepared Al2O3 sol. Accordingly, the hyperbolic band model was used to determine the optical band gap of colloidal alumina nanocrystals. X‐Ray diffraction pattern was used to study the crystallographic phase of the dried gel. Morphological characterization was performed using scanning electron microscopy (SEM). Inductively Coupled Plasma (ICP) emission spectroscopy was used to determination purity of the Al2O3 powder. High‐resolution TEM showed that the diameter of colloidal nanocrystals is about 10 nm. Photoluminescence spectroscopy demonstrated that quantum yields for colloidal nanocrystals are 68% with 300 nm excitation wavelength. The experimental observations confirm that highly stable alumina sol with strong UV emission was synthesized. The mentioned optical properties have not been reported before. 相似文献
Liquid–liquid phase separation (LLPS) is a molecular process that leads to the formation of membraneless organelles, representing functionally specialized liquid-like cellular condensates formed by proteins and nucleic acids. Integrating the data on LLPS-associated proteins from dedicated databases revealed only modest agreement between them and yielded a high-confidence dataset of 89 human LLPS drivers. Analysis of the supporting evidence for our dataset uncovered a systematic and potentially concerning difference between protein concentrations used in a good fraction of the in vitro LLPS experiments, a key parameter that governs the phase behavior, and the proteomics-derived cellular abundance levels of the corresponding proteins. Closer scrutiny of the underlying experimental data enabled us to offer a sound rationale for this systematic difference, which draws on our current understanding of the cellular organization of the proteome and the LLPS process. In support of this rationale, we find that genes coding for our human LLPS drivers tend to be dosage-sensitive, suggesting that their cellular availability is tightly regulated to preserve their functional role in direct or indirect relation to condensate formation. Our analysis offers guideposts for increasing agreement between in vitro and in vivo studies, probing the roles of proteins in LLPS. 相似文献
ABSTRACT Cadmium as a highly toxic metal is released into the environment through paper production, metal processing, phosphate fertilizers, insecticides, and treatment of wastewater. Cadmium also inhibits the body activities and is very toxic for kidney and other organisms. In the current study, zinc-based metal–organic framework, zeolitic imidazolate framework (ZIF)-8, was synthesized and modified by dimethylethylenediamine (ZIF-8-mmen) for the removal of cadmium. To optimize the experiments, response surface methodology was applied with three variables including pH, adsorbent dosage, and contact time using central composite design. The optimum conditions for pH, dosage, and time were 2, 0.1 g, and 89 min, respectively, with removal efficiency of 85.38%. The Langmuir isotherm (qm = 1000 mg/g) indicates the monolayer adsorption. The kinetic studies reveal that the Lagergren model was predominant and cadmium was not chemisorbed. Thermodynamic parameters show spontaneous, endothermic, and physisorption processes. 相似文献
In this paper the problem of non‐fragile adaptive sliding mode observer design is addressed for a class of nonlinear fractional‐order time‐delay systems with uncertainties, external disturbance, exogenous noise, and input nonlinearity. An H∞ observer‐based adaptive sliding mode control considering the non‐fragility of the observer is proposed for this system. The sufficient asymptotic stability conditions are derived in the form of linear matrix inequalities. It is proven that the sliding surface is reachable in finite time. An illustrative example is provided which corroborates the effectiveness of the theoretical results. 相似文献
The performance of several noise reduction algorithms intended for wideband telephony was evaluated both subjectively and objectively. The chosen algorithms were based on statistical modeling, spectral subtraction, Wiener filtering, or subspace modelling principles. A customized wideband noise reduction database containing speech samples corrupted by three types of background noises at three SNR levels, along with their enhanced versions was created. The overall quality of the speech samples in the database was subsequently rated by a group of listeners with normal hearing capabilities. Comprehensive statistical analyses were performed to assess the reliability of the subjective data, and to assess the performance of noise reduction algorithms across varied noisy conditions. The subjective quality ratings were then used to investigate the performance of several auditory model-based objective quality metrics. Key results from these investigations include: (a) there was a high degree of inter- and intra-subject reliability in the subjective ratings, (b) noise reduction algorithms enhance speech quality for only a subset of the noise conditions, and (c) auditory model-based metrics perform similarly in predicting speech quality ratings, when speech quality scores pertaining to a particular noise condition were averaged. 相似文献
In this paper, an agent matching method for bilateral contracts in a multi-agent market is proposed. Each agent has a hierarchical representation of its trading commodity attributes by a tree structure of fuzzy attributes. Using this structure, the similarity between the trees of each pair of buyer and seller is computed using a new ordered fuzzy similarity algorithm. Then, using the concept of Stackelberg equilibrium in a leader–follower game, matchmaking is performed among the sellers and buyers. The fuzzy similarities of each agent with others in its personal viewpoint have been used as its payoffs in a bimatrix game. Through a case study for bilateral contracts of energy, the capabilities of the proposed agent-based system are illustrated. 相似文献
Spectrum-based fault localization (SFL) techniques have shown considerable effectiveness in localizing software faults. They leverage a ranking metric to automatically assign suspiciousness scores to certain entities in a given faulty program. However, for some programs, the current SFL ranking metrics lose effectiveness. In this paper, we introduce ConsilientSFL that is served to synthesize a new ranking metric for a given program, based on a customized combination of a set of given ranking metrics. ConsilientSFL can be significant since it demonstrates the usage of voting systems into a software engineering task. First, several mutated, faulty versions are generated for a program. Then, the mutated versions are executed with the test data. Next, the effectiveness of each existing ranking metric is computed for each mutated version. After that, for each mutated version, the computed existing metrics are ranked using a preferential voting system. Consequently, several top metrics are chosen based on their ranks across all mutated versions. Finally, the chosen ranking metrics are normalized and synthesized, yielding a new ranking metric. To evaluate ConsilientSFL, we have conducted experiments on 27 subject programs from Code4Bench and Siemens benchmarks. In the experiments, we found that ConsilientSFL outperformed every single ranking metric. In particular, for all programs on average, we have found performance measures recall, precision, f-measure, and percentage of code inspection, to be nearly 7, 9, 12, and 5 percentages larger than using single metrics, respectively. The impact of this work is twofold. First, it can mitigate the issue with the choice and usage of a proper ranking metric for the faulty program at hand. Second, it can help debuggers find more faults with less time and effort, yielding higher quality software.
Iron‐oxide nanoparticles (IONPs) have been widely favoured due to their biodegradable, low cytotoxic effects and having reactive surface which can be altered with biocompatible coatings. Considering various medical applications of IONPs, the authors were encouraged to study whether IONPs could be effective against fungal infections caused by Candida species. In this study, IONPs were characterised by scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectroscopy and vibrating sample magnetometer. The goal of this study was to evaluate the antifungal activity of IONPs against different Candida spp. compared with fluconazole (FLC). IONPs were spherical with the size of 30–40 nm. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of IONPs ranged from 62.5 to 500 µg/ml and 500 to 1000 μg/ml, respectively. The MIC and MFC of FLC were in range of 16–128 μg/ml and 64–512 μg/ml, respectively. The growth inhibition value indicated that Candida tropicalis, Candida albicans and Candida glabrata spp. were most susceptible to IONPs. The finding showed that the IONPs possessed antifungal potential against pathogenic Candida spp. and could inhibit the growth of all the tested Candida spp. Further studies, both in vitro and in vivo (including susceptibility, toxicity, Probability of kill (PK) and efficacy studies) are needed to determine whether IONPs are suitable for medicinal purposes.Inspec keywords: iron compounds, nanoparticles, nanomedicine, biomedical materials, microorganisms, cellular biophysics, toxicology, drugs, scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectraOther keywords: antifungal effect, iron‐oxide nanoparticles, Candida species, biodegradable effects, cytotoxic effects, reactive surface, biocompatible coatings, medical applications, IONP, fungal infections, Candidiasis, immunocompromised hosts, antifungal drugs, resistant organisms, antifungal properties, side effects, chemical drugs, scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, vibrating sample magnetometer, antifungal activity, disc diffusion, broth microdilution, minimal inhibitory concentration, minimum fungicidal concentration, Candida tropicalis, Candida Albicans, Candida glabrata, antifungal potential, Fe3 O4相似文献