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1.
DV Matei F Pascale A Clemente F Della Corte D Pucello F Grassetti 《Canadian Metallurgical Quarterly》1996,20(3):302-306
Since in vitro experiments had excluded interactions between Fe-gluconate (Fe-gluc) and magnesium-L-aspartate hydrochloride (MAH) in aqueous solutions the present in vivo studies seemed to be justified. Animal studies: Rats were kept on magnesium-(Mg)- and iron-(Fe)- sufficient and deficient diets. The intragastral administration of Fe-gluc significantly increased plasma Fe after 3 h, either given alone, or in combination with MAH (inducing hypermagnesemia). Same results were obtained when fortified diets were offered to Fe/Mg-deficient animals. Human studies: The combination of Fe-gluc (2 x 50 mg Fe per day, per os) plus MAH (2 x 7.5 mmol Mg per day, p.o.) was well tolerated by healthy volunteers. Single dose experiments revealed that Fe-gluc alone and in combination with MAH increased plasma Fe levels during 3 h to the same extent. Two groups of pregnant women with moderately reduced hemoglobin levels either received Fe-gluc (out-patients) or its combination with MAH (at least temporarily hospitalised because of preterm labor). Treatments were well tolerated. Hemoglobin levels did not further decrease, as expected without Fe supplements, during the course of pregnancy, thus indicating the therapeutic availability of the electrolytes in both study groups. Progesterone-induced constipation is frequently observed during pregnancy; hence stool softening reported by 50% of the women receiving Fe-gluc plus MAH (versus 33% in the Fe-gluc group) can be regarded as desirable effect. It is concluded that MAH does not interfere with the enteral absorption of Fe-gluc when both electrolytes are orally administered together. Taking both electrolytes together instead of 2 to 3 h apart from each other, as actually recommended, means a less complicated dosage regimen and probably improves compliance. 相似文献
2.
Pascale Sabin Bouchra Benjelloun-Mlayah Michel Delmas 《Journal of the American Oil Chemists' Society》1997,74(5):481-489
Two sets of alkyd resins of variable oil lengths with the required properties for offset printing ink formulations, modified
by sunflower and rapeseed oil, were synthetized according to the “monoglyceride” process. The influence of the acyl composition
of the modifying vegetable oil and of the oil content on alkyds’ properties was determined by detailed chemical and rheological
characterization. Molecular structure, size, and molecule size distribution appeared to be linked to these two factors. A
comparative study with two usual linseed oil-modified alkyds led to determination of the more appropriate alkyds for applications
in offset varnishes. 相似文献
3.
A. Ritacco R. Adam A. Adane P. Ade P. André A. Beelen B. Belier A. Benoît A. Bideaud N. Billot O. Bourrion M. Calvo A. Catalano G. Coiffard B. Comis A. D’Addabbo F.-X. Désert S. Doyle J. Goupy C. Kramer S. Leclercq J. F. Macías-Pérez J. Martino P. Mauskopf A. Maury F. Mayet A. Monfardini F. Pajot E. Pascale L. Perotto G. Pisano N. Ponthieu M. Rebolo-Iglesias V. Revéret L. Rodriguez G. Savini K. Schuster A. Sievers C. Thum S. Triqueneaux C. Tucker R. Zylka 《Journal of Low Temperature Physics》2016,184(3-4):724-732
4.
Daniel Cosmin Porumbel Jin-Kao Hao Pascale Kuntz 《Computers & Operations Research》2010,37(4):769-778
We present a search space analysis and its application in improving local search algorithms for the graph coloring problem. Using a classical distance measure between colorings, we introduce the following clustering hypothesis: the high quality solutions are not randomly scattered in the search space, but rather grouped in clusters within spheres of specific diameter. We first provide intuitive evidence for this hypothesis by presenting a projection of a large set of local minima in the 3D space. An experimental confirmation is also presented: we introduce two algorithms that exploit the hypothesis by guiding an underlying Tabu Search (TS) process. The first algorithm (TS-Div) uses a learning process to guide the basic TS process toward as-yet-unvisited spheres. The second algorithm (TS-Int) makes deep investigations within a bounded region by organizing it as a tree-like structure of connected spheres. We experimentally demonstrate that if such a region contains a global optimum, TS-Int does not fail in eventually finding it. This pair of algorithms significantly outperforms the underlying basic TS algorithm; it can even improve some of the best-known solutions ever reported in the literature (e.g. for dsjc1000.9). 相似文献
5.
This study examined the implementation of imaging technology into two public sector organizations in the Midwest in the USA. The aims of the study were to analyze the impact of imaging technology on job characteristics and quality of working life, and the influence of the technological change process on employees and organizations. Quantitative and qualitative data were collected using questionnaire surveys and structured and semi-structured interviews. Results showed that imaging users reported more problems with technology and less job satisfaction than employees who were still using their 'old' computer systems. In addition, imaging users in the organization that utilized end user participation in the implementation of their imaging system rated their imaging systems better and reported higher job satisfaction than imaging users in the organization that did not incorporate end user participation in the implementation of the system. The results are discussed in terms of the importance of the technology implementation/ change process, and future directions for research are provided. 相似文献
6.
Jean-Baptiste Domergue Julie Lalande Daniel Beucher Pascale Satour Cyril Abadie Anis M. Limami Guillaume Tcherkez 《International journal of molecular sciences》2022,23(15)
Seed size is often considered to be an important trait for seed quality, i.e., vigour and germination performance. It is believed that seed size reflects the quantity of reserve material and thus the C and N sources available for post-germinative processes. However, mechanisms linking seed size and quality are poorly documented. In particular, specific metabolic changes when seed size varies are not well-known. To gain insight into this aspect, we examined seed size and composition across different accessions of barrel medic (Medicago truncatula Gaertn.) from the genetic core collection. We conducted multi-elemental analyses and isotope measurements, as well as exact mass GC–MS metabolomics. There was a systematic increase in N content (+0.17% N mg−1) and a decrease in H content (–0.14% H mg−1) with seed size, reflecting lower lipid and higher S-poor protein quantity. There was also a decrease in 2H natural abundance (δ2H), due to the lower prevalence of 2H-enriched lipid hydrogen atoms that underwent isotopic exchange with water during seed development. Metabolomics showed that seed size correlates with free amino acid and hexoses content, and anticorrelates with amino acid degradation products, disaccharides, malic acid and free fatty acids. All accessions followed the same trend, with insignificant differences in metabolic properties between them. Our results show that there is no general, proportional increase in metabolite pools with seed size. Seed size appears to be determined by metabolic balance (between sugar and amino acid degradation vs. utilisation for storage), which is in turn likely determined by phloem source metabolite delivery during seed development. 相似文献
7.
Marine Milard Fabienne Laugerette Annie Durand Charline Buisson Emmanuelle Meugnier Emmanuelle Loizon Corinne Louche‐Pelissier Valrie Sauvinet Lorna Garnier Sbastien Viel Karne Bertrand Florent Joffre David Cheillan Lydie Humbert Dominique Rainteau Pascale Plaisanci Laure B. Bindels Audrey M. Neyrinck Nathalie M. Delzenne Marie‐Caroline Michalski 《Molecular nutrition & food research》2019,63(4)
8.
Polysaccharides,oligosaccharides and nitrogenous compounds change during the ageing of Tempranillo and Verdejo sparkling wines 下载免费PDF全文
9.
Clémence Demangel Delphine Auzène Muriel Vayssade Jean-Luc Duval Pascale Vigneron Marie-Danièle Nagel Jean-Claude Puippe 《Materials science & engineering. C, Materials for biological applications》2012,32(7):1919-1925
Metal injection molding (MIM) is a near net shape manufacturing method that allows for the production of components of small to moderate size and complex shape. MIM is a cost-effective and flexible manufacturing technique that provides a large innovative potential over existing methods for the industry of implantable devices. Commercially pure titanium (CP-Ti) samples were machined to the same shape as a composite feedstock with titanium and polyoxymethylene, and these metals were injected, debinded and sintered to assess comparative biological properties. Moreover, we treated MIM-Ti parts with BIOCOAT®, BIODIZE® and BIOCER®, three different anodic oxidation techniques that treat titanium using acid, alkaline and anion enriched electrolytes, respectively. Cytocompatibility as well as morphological and chemical features of surfaces was comparatively assessed on each sample, and the results revealed that MIM-Ti compared to CP-Ti demonstrated a specific surface topography with a higher roughness. MIM-Ti and BIOCER® samples significantly enhanced cell proliferation, cell adhesion and cell differentiation compared to CP-Ti. Interestingly, in the anodization post-treatment established in this study, we demonstrated the ability to improve osseointegration through anionic modification treatment. The excellent biological response we observed with MIM parts using the injection molding process represents a promising manufacturing method for the future implantable devices in direct contact with bones. 相似文献
10.
Laurent Bédouet Florentina Pascale Michel Bonneau Alexandre Laurent 《Drug development and industrial pharmacy》2015,41(1):85-94
Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13?days with LPS in combination with S-(+)-ibuprofen at 50?µM and 1?mM. S-(+)-ibuprofen (50?µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1?mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p?=?0.0072), proteoglycans degradation by 35% (p?=?0.0114) and expression of serum amyloid protein – the main protein induced upon LPS challenge – by 44% (p?0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1?mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50?µM in all treatment groups and reduction of cartilage degradation observed at 1?mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. 相似文献