Genetic and Epigenomic Modifiers of Diabetic Neuropathy

Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN.     

Self and mutual ground impedances of cylindrical metal plates buried in homogeneous earth

This paper presents a numerical procedure for computation of self and mutual impedance of cylindrical metal plates buried in homogeneous earth. Procedure is based on an analytical expression for scalar potential distribution of an equipotential metal plate in homogeneous unbounded medium. The effect of the air–earth boundary condition is taken into account by the exact imaging method. The robustness and accuracy of the computation procedure is based on the combination of analytical integration and 1D and 2D Gaussian quadratures for solving integrals present in expressions for self and mutual ground impedances of metal plates. The attenuation and phase shift is taken into account approximately by introducing the attenuation‐phase shift factor. The numerical procedure developed for the computation of self and mutual ground impedances of cylindrical metal plates buried in homogeneous earth is efficient, numerically stable and generally applicable. Numerical model developed for the computation of self and mutual ground impedances of cylindrical metal plates buried in homogeneous earth represents a basis of a wider numerical model for computation of ground fault current distribution in which grounding grids are approximated by metal cylindrical plates. Copyright © 2014 John Wiley & Sons, Ltd.     

Load forecasting using a multivariate meta-learning system

Although over a thousand scientific papers address the topic of load forecasting every year, only a few are dedicated to finding a general framework for load forecasting that improves the performance, without depending on the unique characteristics of a certain task such as geographical location. Meta-learning, a powerful approach for algorithm selection has so far been demonstrated only on univariate time-series forecasting. Multivariate time-series forecasting is known to have better performance in load forecasting. In this paper we propose a meta-learning system for multivariate time-series forecasting as a general framework for load forecasting model selection. We show that a meta-learning system built on 65 load forecasting tasks returns lower forecasting error than 10 well-known forecasting algorithms on 4 load forecasting tasks for a recurrent real-life simulation. We introduce new metafeatures of fickleness, traversity, granularity and highest ACF. The meta-learning framework is parallelized, component-based and easily extendable.     

Charge–discharge characteristics of polythiopheneas a cathode active material in a rechargeable battery

Polythiophene films were electrochemically deposited on glassy carbon substrates under potentiostatic control and used as cathode active material together with a Zn anode in a rechargeable battery with propylene carbonate, Zn(ClO4)2, LiClO4 electrolyte. Charge–discharge characteristics were studied. The average discharge voltage of the polythiophene/Zn cell was 1.25V. In the low current density region (i.e. 10–50μAcm?2) the cycling coulombic efficiency was above 95%, but in the fast charge–discharge region, where current densities were 0.1–0.5mAcm?2, the coulombic efficiency decreased to 55% with increasing discharge rate. Additionally, it was found that the cyclic coulombic efficiency was a function of the charging depth.     

Enhancement of electrocatalytic properties of carbonized polyaniline nanoparticles upon a hydrothermal treatment in alkaline medium

The electrocatalytic activity of carbonized polyaniline nanostructures (Carb-nanoPANI) towards oxygen reduction reaction (ORR), estimated in 0.1 mol dm⁻³ KOH solution, was significantly improved upon a hydrothermal treatment in 1 mol dm⁻³ KOH solution. Namely, the onset of ORR was shifted by ∼70 mV to more positive potentials, and the number of electrons consumed per O₂ molecule was enhanced in comparison to the original material. The number of electrons involved in ORR depended on loading, and with a loading of 0.5 mg cm⁻², for the potentials lower than −0.5 V vs SCE, the number of electrons approached 4. For this material, high stability of electrochemical behavior and resistance to the poisoning by ethanol was evidenced by potentiodynamic cycling.     

Oxygen reduction on anodically formed titanium dioxide

Oxygen reduction on anodically formed TiO₂ was studied in both alkaline and acidic water solutions, using dc voltammetry combined with the rotating disk technique. The possible interference with hydrogen evolution reaction was considered. By means of Levich-Koutecky plot, in alkaline media, 4e⁻ reduction path was confirmed, while with the transition to acidic media, the rising participation of the indirect, 2e⁻ reduction path was evidenced.     

Error Analysis of Surface Temperature Measurement by Infrared Sensor

The general mathematical model for the surface temperature measurement based on infrared radiation is proposed. Measurement error function is derived and analyzed. The results of analyze are presented and conditions of measurement for better measurement accuracy are determined.     

Time-harmonic analysis of grounding system in horizontally stratified multilayer medium

This paper extends an electromagnetic model for time-harmonic analysis of grounding system in horizontally stratified multilayer medium which consists of air and arbitrary number of soil layers. Complete electromagnetic coupling between grounding system segments is taken into account. The model is based on applying the finite element technique to an integral equation formulation. Through an effective approximation of the attenuation and phase shift effects the computation of Sommerfeld integrals has been avoided, which considerably shortens the computational time. The treatment of non-horizontal segments of grounding grid conductors has been resolved by approximating the segment with five current point sources distributed along the segment length. An algorithm for scalar electric potential computation in any soil layers is presented and compared to published results. The effects of approximating a complex heterogeneous earth structure with a homogeneous earth is also analyzed and discussed.     

Rheum rhaponticum Root Extract Improves Vasomotor Menopausal Symptoms and Estrogen-Regulated Targets in Ovariectomized Rat Model

Ovarian insufficiency and ovariectomy are characterized by deregulated heat loss mechanisms. Unlike hormone therapy, ERr 731 (a standardized botanical extract of Siberian rhubarb Rheum rhaponticum L. high in rhaponticin) acts like a selective estrogen receptor modulator for ERβ receptors and may offer a higher degree of safety while maintaining the desired efficacy profile. In this study, we examined the relationship between oral administration of ERr 731 and the underlying components of skin vasomotion responses in an ovariectomized (OVX) rat model. ERr 731 dose-dependently reduced tail skin temperature (T_skin) values by an average of 1 °C. The rapid onset of this effect was observed in 1 and 3 mg/kg/day ERr 731 groups as early as day 2 of administration, and remained in place for the duration of the treatment (2 weeks). Substituting ERr 731 after E₂ withdrawal helped maintain body temperature similarly to E₂ alone, suggesting the usefulness of ERr 731 for replacing existing hormonal therapy in humans. ERr 731 also acted as a highly selective agonist for ERβ in the hypothalamus of OVX rats, as well as in ERα/β cell-based reporter assays. These data validate the OVX/T_skin rat model as a suitable screening platform to evaluate botanical and pharmaceutical treatments of menopause, while providing further evidence for the efficacy of ERr 731 towards alleviating vasomotor menopausal symptoms and improving wellbeing during the menopausal transition.