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1.
The hurdle effect of osmotic pretreatment and high‐pressure cold pasteurisation on the shelf‐life extension of fresh‐cut tomatoes 下载免费PDF全文
Efimia K. Dermesonlouoglou Varvara Andreou Zacharias Alexandrakis George J. Katsaros Maria C. Giannakourou Petros S. Taoukis 《International Journal of Food Science & Technology》2017,52(4):916-926
Tomatoes are perishable products due to the activity of microorganisms and endogenous enzymes. The objective was to produce cut tomatoes with extended shelf life, using the combined hurdle effect of osmotic pretreatment (OD) and high pressure (HP), instead of a conventional one‐step thermal process. Samples were processed in a multicomponent osmotic solution at 35 °C, subsequently cold‐pasteurised in pack at 600 MPa and stored at 5–15 °C. Quality deterioration during isothermal and nonisothermal storage was kinetically modelled. Both OD process and OD‐HP combined process caused an increase in lycopene content that was well retained. Texture, colour and flavour of treated samples were evaluated as similar to fresh, with OD‐HP samples showing better retention during storage. Being microbiologically stable, shelf life of OD‐HP samples was limited by sensory deterioration, whereas OD samples were rejected due to eventual microbial growth. Shelf life of OD and OD‐HP samples was estimated at 77 and 181 days, respectively, at 5 °C. 相似文献
2.
L. Muresan S. Varvara E. Stupnišek-Lisac H. Otma?i? K. Maruši? S. Horvat-Kurbegovi? K. Rahmouni 《Electrochimica acta》2007,52(27):7770-7779
Cultural bronze artefacts are exposed in indoor or outdoor environment. They often suffer of a substantial alteration due to an increasing atmospheric pollution. In this work, we propose the use of some innoxious compounds as corrosion inhibitors of bronze objects covered with patina. The bronze used was Cu-6Sn (in wt.%). This composition was selected after a preliminary work on several archaeological bronzes found in Transylvania, Romania, dated from the Late Neolithic to Roman periods. First, an artificial patina was formed on Cu-6Sn bronze under potential regulation, in 0.2 g L−1 NaHCO3 + 0.2 g L−1 Na2SO4 aqueous solution (pH 8), during 4 days. A pale blue to green patina was obtained and characterized using EDS and Raman spectroscopy. Then, four innoxious organic substances were examined as corrosion inhibitors: 5 mM 4-methyl-1-(p-tolyl)-imidazole (TMI), 10 mM 1-phenyl 4-methyl-imidazole (PMI), 1 mM 2-mercapto 5-R-acetylamino-1,3,4-thiadiazole (MAcT), 1 mM 2-mercapto 5-R-amino-1,3,4-thiadiazole (MAT), and for comparison 1 mM benzotriazole (BTA). The impedance spectra collected showed, for all of them, three depressed capacitive loops. On the basis of these capacitance values, these loops were allocated to the surface film with ionic conduction, the double layer capacitance with the charge transfer resistance, and the oxidation-reduction process involving the surface patina. TMI and MAcT were found to be efficient inhibitors though their performances are significantly lower than that of BTA. 相似文献
3.
Direct Staudinger–Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De‐N‐acetylases 下载免费PDF全文
Rishikesh Ariyakumaran Varvara Pokrovskaya Dustin J. Little P. Lynne Howell Mark Nitz 《Chembiochem : a European journal of chemical biology》2015,16(9):1350-1356
De‐N‐acetylases of β‐(1→6)‐D ‐N‐acetylglucosamine polymers (PNAG) and β‐(1→4)‐D ‐N‐acetylglucosamine residues in peptidoglycan are attractive targets for antimicrobial agents. PNAG de‐N‐acetylases are necessary for biofilm formation in numerous pathogenic bacteria. Peptidoglycan de‐N‐acetylation facilitates bacterial evasion of innate immune defenses. To target these enzymes, transition‐state analogue inhibitors containing a methylphosphonamidate have been synthesized through a direct Staudinger–phosphonite reaction. The inhibitors were tested on purified PgaB, a PNAG de‐N‐acetylase from Escherichia coli, and PgdA, a peptidoglycan de‐N‐acetylase from Streptococcus pneumonia. Herein, we describe the most potent inhibitor of peptidoglycan de‐N‐acetylases reported to date (Ki=80 μM ). The minimal inhibition of PgaB observed provides insight into key structural and functional differences in these enzymes that will need to be considered during the development of future inhibitors. 相似文献
4.
Seismic design of waste landfills has been a subject of intense research over the past two decades, primarily due to the severe environmental impact of a potential failure. The majority of the related studies have been focused on the stability assessment of landfills utilizing permanent deformation methods. However, previous investigations have not fully addressed the impact of the composite liner system on the seismic performance of the geostructure, mainly expressed as potential sliding development, which is greatly affected by the geometry and the resulting initial static stress state of the landfill. Therefore, the aforementioned issues are investigated via a detailed parametric study, where the dynamic behaviour of the composite liner system is examined both analytically and numerically. The conducted coupled analyses indicated that the most significant parameters of the complex dynamic response of waste landfills can be reduced in two ratios that comprise functions of the main characteristics of the geostructure and of the excitation. Moreover, two distinct failure patterns have been identified with respect to the characteristics of the distribution of the permanent displacements along the interface and the axial deformation along the geosynthetic. The occurrence conditions of these failure patterns can be determined in terms of the two abovementioned ratios as verified by the analytical results of the critical acceleration of a simple SDOF system. 相似文献
5.
Ionut Zamblau Simona Varvara Liana Maria Muresan 《Journal of Materials Science》2011,46(20):6484-6490
Copper silica composite coatings are an attractive alternative to chromium and nickel coatings in order to avoid environmental
problems and for application in electrical devices. However, co-deposition of SiO2 particles with metals occurs to a rather limited extent, generally under 1%, due to the hydrophilicity of SiO2, which makes the incorporation of particles in a metallic matrix difficult. To overcome this drawback, the influence of cetyl
trimethyl ammonium bromide (CTAB) on the deposition and corrosion behavior of Cu–SiO2 coatings on steel has been studied. It was established that CTAB plays a beneficial role in SiO2 suspension stabilization, promotes the co-deposition of nanoparticles in the copper matrix and improves the deposit morphology
and structure. Consequently, a higher corrosion resistance of Cu–SiO2 deposits obtained in the presence of CTAB was noticed. The most important effect was observed in the case when CTAB was used
in concentration of 10−3 M in the electroplating bath. 相似文献
6.
7.
Elena G. Varlamova Mikhail V. Goltyaev Valentina N. Maltseva Egor A. Turovsky Ruslan M. Sarimov Alexander V. Simakin Sergey V. Gudkov 《International journal of molecular sciences》2021,22(15)
In recent decades, studies on the functional features of Se nanoparticles (SeNP) have gained great popularity due to their high biocompatibility, stability, and pronounced selectivity. A large number of works prove the anticarcinogenic effect of SeNP. In this work, the molecular mechanisms regulating the cytotoxic effects of SeNP, obtained by laser ablation, were studied by the example of four human cancer cell lines: A-172 (glioblastoma), Caco-2, (colorectal adenocarcinoma), DU-145 (prostate carcinoma), MCF-7 (breast adenocarcinoma). It was found that SeNP had different concentration-dependent effects on cancer cells of the four studied human lines. SeNP at concentrations of less than 1 μg/mL had no cytotoxic effect on the studied cancer cells, with the exception of the A-172 cell line, for which 0.5 μg/mL SeNP was the minimum concentration affecting its metabolic activity. It was shown that SeNP concentration-dependently caused cancer cell apoptosis, but not necrosis. In addition, it was found that SeNP enhanced the expression of pro-apoptotic genes in almost all cancer cell lines, with the exception of Caco-2 and activated various pathways of adaptive and pro-apoptotic signaling pathways of UPR. Different effects of SeNP on the expression of ER-resident selenoproteins and selenium-containing glutathione peroxidases and thioredoxin reductases, depending on the cell line, were established. In addition, SeNP triggered Ca2+ signals in all investigated cancer cell lines. Different sensitivity of cancer cell lines to SeNP can determine the induction of the process of apoptosis in them through regulation of the Ca2+ signaling system, mechanisms of ER stress, and activation of various expression patterns of genes encoding pro-apoptotic proteins. 相似文献
8.
Vasilopoulos Ilias Asouti Varvara G. Giannakoglou Kyriakos C. Meyer Marcus 《Engineering with Computers》2021,37(1):449-459
Engineering with Computers - Multi-objective optimization has been rising in popularity, especially within an industrial environment, where several cost functions often need to be considered during... 相似文献
9.
E. V. Naydenkin I. V. Ratochka I. P. Mishin O. N. Lykova N. V. Varlamova 《Journal of Materials Science》2017,52(8):4164-4171
The effect of volume fraction of the β-phase on the mechanical and superplastic properties of ultrafine-grained titanium alloys with grain size d of ~0.2 µm was investigated by transmission and scanning electron microscopy, X-ray diffraction analysis, and tensile test experiments. The ultrafine-grained structure of the materials was formed by the multi-directional pressing technique. The structure in question is shown to improve the mechanical properties by 30–50 % and to lower down to 823 K, the temperature at which superplastic flow starts as compared to coarse-grained analogs, no matter what the phase composition and concentration of the alloying elements used. The reduced temperature is attributable to the activation of diffusion-controlled grain boundary sliding in the case of nonequilibrium interfaces of materials produced by severe plastic deformation. The fraction of the β-phase and its precipitation pattern are found to have significant influence on the temperature range in which superplastic flow occurs and on the maximum elongation to failure. A near-β Ti-5Al-5Mo-5V-1Cr-1Fe alloy with a large fraction of the β-phase (>34 %) under superplastic conditions exhibits record-breaking strains (>1300 %) that do not cause fracture of the material and extremely low flow stresses. This is associated with the activation of the grain boundary sliding due to an increase in the diffusivity along the phase boundaries in a case of microduplex structure. 相似文献
10.
Egor A. Turovsky Elena G. Varlamova Egor Y. Plotnikov 《International journal of molecular sciences》2021,22(16)
Ischemia-like conditions reflect almost the entire spectrum of events that occur during cerebral ischemia, including the induction of oxidative stress, Ca2+ overload, glutamate excitotoxicity, and activation of necrosis and apoptosis in brain cells. Mechanisms for the protective effects of the antioxidant enzyme peroxiredoxin-6 (Prx-6) on hippocampal cells during oxygen-glucose deprivation/reoxygenation (OGD/R) were investigated. Using the methods of fluorescence microscopy, inhibitory analysis, vitality tests and PCR, it was shown that 24-h incubation of mixed hippocampal cell cultures with Prx-6 does not affect the generation of a reversible phase of a OGD-induced rise in Ca2+ ions in cytosol ([Ca2+]i), but inhibits a global increase in [Ca2+]i in astrocytes completely and in neurons by 70%. In addition, after 40 min of OGD, cell necrosis is suppressed, especially in the astrocyte population. This effect is associated with the complex action of Prx-6 on neuroglial networks. As an antioxidant, Prx-6 has a more pronounced and astrocyte-directed effect, compared to the exogenous antioxidant vitamin E (Vit E). Prx-6 inhibits ROS production in mitochondria by increasing the antioxidant capacity of cells and altering the expression of genes encoding redox status proteins. Due to the close bond between [Ca2+]i and intracellular ROS, this effect of Prx-6 is one of its protective mechanisms. Moreover, Prx-6 effectively suppresses not only necrosis, but also apoptosis during OGD and reoxygenation. Incubation with Prx-6 leads to activation of the basic expression of genes encoding protective kinases—PI3K, CaMKII, PKC, anti-apoptotic proteins—Stat3 and Bcl-2, while inhibiting the expression of signaling kinases and factors involved in apoptosis activation—Ikk, Src, NF-κb, Caspase-3, p53, Fas, etc. This effect on the basic expression of the genome leads to the cell preconditions, which is expressed in the inhibition of caspase-3 during OGD/reoxygenation. A significant effect of Prx-6 is directed on suppression of the level of pro-inflammatory cytokine IL-1β and factor TNFα, as well as genes encoding NMDA- and kainate receptor subunits, which was established for the first time for this antioxidant enzyme. The protective effect of Prx-6 is due to its antioxidant properties, since mutant Prx-6 (mutPrx-6, Prx6-C47S) leads to polar opposite effects, contributing to oxidative stress, activation of apoptosis and cell death through receptor action on TLR4. 相似文献