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Saoula N. Bait L. Sali S. Azibi M. Hammouche A. Madaoui N. 《Protection of Metals and Physical Chemistry of Surfaces》2019,55(4):743-747
Protection of Metals and Physical Chemistry of Surfaces - TiOxNy films were grown onto 316L stainless steel substrate using radiofrequency (rf) magnetron sputtering from a pure titanium nitride... 相似文献
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Azzoug M. O. Boutarek-Zaourar N. Aboudi D. Madaoui N. Mossang E. Chentouf S. 《中国铸造》2018,15(3):228-235
The purpose of this study was to determine the impact of niobium addition as an inoculation element on the microstructure and electrochemical properties of EN-FGL250 gray cast iron. Niobium additions are in a powder form and have a 0.5 mm particle size at dfferent proportions of 1 wt.% and 3 wt.%. The addition was done during casting of the metal in the mold at the last cooling step of the melt cast iron. These additions have a significant impact on the phenomenon of solidifi cation as the metal powder deposited in the sand molds creates new centers of germination and absorbs a lot of heat. The cooling rate directly affects the microstructure and electrochemical behavior. This is confirmed by SEM observations and electrochemical tests. Furthermore, the addition of niobium transforms the microstructure of gray cast iron from cellular structure into totally dendritic structure. As a consequence, the niobium addition affected the shape and size of graphite, thus considerably reducing the corrosion current density by increasing the polarization resistance Rp. 相似文献
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Dr. Mimouna Madaoui Dr. Olivier Vidal Albert Meyer Mathieu Noël Prof. Dr. Jean-Marie Lacroix Dr. Jean-Jacques Vasseur Prof. Dr. Alberto Marra Dr. François Morvan 《Chembiochem : a European journal of chemical biology》2020,21(23):3433-3448
Galacto- and fuco-clusters conjugated with one to three catechol or hydroxamate motifs were synthesised to target LecA and LecB lectins of Pseudomonas aeruginosa (PA) localised in the outer membrane and inside the bacterium. The resulting glycocluster–pseudosiderophore conjugates were evaluated as Trojan horses to cross the outer membrane of PA by iron transport. The data suggest that glycoclusters with catechol moieties are able to hijack the iron transport, whereas those with hydroxamates showed strong nonspecific interactions. Mono- and tricatechol galactoclusters ( G1C and G3C ) were evaluated as inhibitors of infection by PA in comparison with the free galactocluster ( G0 ). All of them exhibited an inhibitory effect between 46 to 75 % at 100 μM, with a higher potency than G0 . This result shows that LecA localised in the outer membrane of PA is involved in the infection mechanism. 相似文献
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Design and Synthesis of Galactosylated Bifurcated Ligands with Nanomolar Affinity for Lectin LecA from Pseudomonas aeruginosa 下载免费PDF全文
Dr. Anthony Angeli Muchen Li Dr. Lucie Dupin Dr. Gérard Vergoten Mathieu Noël Mimouna Madaoui Dr. Shuai Wang Albert Meyer Thomas Géhin Dr. Sébastien Vidal Dr. Jean‐Jacques Vasseur Dr. Yann Chevolot Dr. François Morvan 《Chembiochem : a European journal of chemical biology》2017,18(11):1036-1047
Lectin A (LecA) from Pseudomonas aeruginosa is an established virulence factor. Glycoclusters that target LecA and are able to compete with human glycoconjugates present on epithelial cells are promising candidates to treat P. aeruginosa infection. A family of 32 glycodendrimers of generation 0 and 1 based on a bifurcated bis‐galactoside motif have been designed to interact with LecA. The influences both of the central multivalent core and of the aglycon of these glycodendrimers on their affinity toward LecA have been evaluated by use of a microarray technique, both qualitatively for rapid screening of the binding properties and also quantitatively (Kd). This has led to high‐affinity LecA ligands with Kd values in the low nanomolar range (Kd=22 nm for the best one). 相似文献
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Madaoui N. Saoula N. Kheyar K. Nezar S. Tadjine R. Hammouche A. Belhousse S. 《Protection of Metals and Physical Chemistry of Surfaces》2017,53(3):527-533
Protection of Metals and Physical Chemistry of Surfaces - Anticorrosion TiO2 films were deposited by reactive r.f. magnetron sputtering method, on stainless steel substrates. The effect of bias... 相似文献
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