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排序方式: 共有187条查询结果,搜索用时 187 毫秒
1.
The numerical simulation of comparative elastohydrodynamic lubrication between axisymmetrical and 3D elastic approaches on the radial lip seals is presented in order to determine the 3D effect of the elastic aspect of the seal lip. Indeed, the consideration of 3D model in other words the circumferential variation of the lip elastic deformation indicated a difference in the deformation distribution of the lip compared to the axisymmetrical approach. Consequently, the results show that the presence of the circumferential variation of the seal lip deformation has a significant effect on the pumping rate values. 相似文献
2.
Gianluca Selvaggio Claudine Chaouiya Florence Janody 《International journal of molecular sciences》2021,22(9)
The multistep development of cancer involves the cooperation between multiple molecular lesions, as well as complex interactions between cancer cells and the surrounding tumour microenvironment. The search for these synergistic interactions using experimental models made tremendous contributions to our understanding of oncogenesis. Yet, these approaches remain labour-intensive and challenging. To tackle such a hurdle, an integrative, multidisciplinary effort is required. In this article, we highlight the use of logical computational models, combined with experimental validations, as an effective approach to identify cooperative mechanisms and therapeutic strategies in the context of cancer biology. In silico models overcome limitations of reductionist approaches by capturing tumour complexity and by generating powerful testable hypotheses. We review representative examples of logical models reported in the literature and their validation. We then provide further analyses of our logical model of Epithelium to Mesenchymal Transition (EMT), searching for additional cooperative interactions involving inputs from the tumour microenvironment and gain of function mutations in NOTCH. 相似文献
3.
Koechlin L Lawson PR Mourard D Blazit A Bonneau D Morand F Stee P Tallon-Bosc I Vakili F 《Applied optics》1996,35(16):3002-3009
A new fringe tracker based on photon-counting detectors and real-time image processing has been implemented on the Grand Interféromètre à 2 Télescopes at the Observatoire de la Cote d'Azur. Fringe visibilities have been recorded on P Cygni and other stars across the Hαemission line with optical path differences stabilized to between 4 and 7 μm rms (1% of the coherence length). We present our initial results and describe the principle, implementation, and performance of the fringe tracker. 相似文献
4.
Kátia Cordeiro Mendonça Marc Olivier Abadie Claudine Béghein Patrice Blondeau 《Building Simulation》2014,7(5):489-501
The objective of this work is to evaluate the quality of the zonal airflow predictions compared to those provided by computational fluid dynamics (CFD) tools for an isothermal airflow induced in a room by a linear ceiling diffuser. This comparative analysis was conducted for a typical rectangular office designed for two people, considering two different arrangements of obstacles within the room volume. The ventilation was provided by a four-way ceiling diffuser type with large aspect ratio slots, the outlet integrated into it, operating in a three-way mode with slot Reynolds number of 2700. As a result, the airflow was transitional or weakly turbulent. The airflow patterns obtained with the zonal models were first compared qualitatively with the CFD computations. A quantitative comparison based on the mean velocities at the interface of the zonal grid was then carried out. The characteristic features of the zonal predictions are shown and the limitations of the zonal and CFD approaches are discussed. 相似文献
5.
Laurent Bédouet Florentina Pascale Michel Bonneau Alexandre Laurent 《Drug development and industrial pharmacy》2015,41(1):85-94
Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13?days with LPS in combination with S-(+)-ibuprofen at 50?µM and 1?mM. S-(+)-ibuprofen (50?µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1?mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p?=?0.0072), proteoglycans degradation by 35% (p?=?0.0114) and expression of serum amyloid protein – the main protein induced upon LPS challenge – by 44% (p?0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1?mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50?µM in all treatment groups and reduction of cartilage degradation observed at 1?mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. 相似文献
6.
7.
We present a multiresolution morphing algorithm using ``as-rigid-as-possible' shape interpolation combined with an angle-length
based multiresolution decomposition of simple 2D piecewise curves. This novel multiresolution representation is defined intrinsically
and has the advantage that the details' orientation follows any deformation naturally. The multiresolution morphing algorithm
consists of transforming separately the coarse and detail coefficients of the multiresolution decomposition. Thus all LoD
(level of detail) applications like LoD display, compression, LoD editing etc. can be applied directly to all morphs without
any extra computation. Furthermore, the algorithm can robustly morph between very large size polygons with many local details
as illustrated in numerous figures. The intermediate morphs behave natural and least-distorting due to the particular intrinsic
multiresolution representation. 相似文献
8.
Volume Preservation of Multiresolution Meshes 总被引:4,自引:0,他引:4
Geometric constraints have proved to be efficient for enhancing the realism of shape animation. The present paper addresses the computation and the preservation of the volume enclosed by multiresolution meshes. A wavelet based representation allows the mesh to be handled at any level of resolution. The key contribution is the calculation of the volume as a trilinear form with respect to the multiresolution coefficients. Efficiency is reached thanks to the pre-processing of a sparse 3D data structure involving the transposition of the filters while represented as a lifting scheme. A versatile and interactive method for preserving the volume during a deformation process is then proposed. It is based on a quadratic minimization subject to a linearization of the volume constraint. A closed form of the solution is derived. 相似文献
9.
Characterization of the granular packing and percolation threshold of reactive powder concrete 总被引:4,自引:0,他引:4
Olivier Bonneau Christian Vernet Micheline Moranville Pierre-Claude Aïtcin 《Cement and Concrete Research》2000,30(12):1861-1867
Reactive powder concrete (RPC) is a new cement-based material developed through microstructural engineering. RPC is composed of very fine powders: sand, crushed quartz and silica fume, all with particle sizes comprised between 300 and 0.02 μm, and a low water content, W/C<0.20. A very dense matrix is achieved by optimizing the granular packing of these powders. This compactness confers to RPC ultrahigh strength and durability.where Av depends on the nature and the dosage of the different mineral and organic components, and Bv is an invariant related to the granular packing. From 19 different RPC compositions, an average value of 12.1 with a standard deviation of 1.7 were found for Bv. The capillary porosity percolation threshold was also deduced from this relationship. It has been found that when the degree of hydration is equal to 26%, the capillary pore space is discontinuous. This last result is in agreement with the prediction of the NIST microstructural model by Bentz and Garboczi [D., Bentz, E. Garboczi, Percolation of phases in a three-dimensional cement paste microstructural model, Cem Concr Res 21 (2) (1991) 325–344]. A continuous determination of the degree of hydration based on electrical conductivity is proposed. 相似文献
The hydration kinetic of the cementitious matrix using electrical conductivity and isothermal calorimetry is presented. A linear relationship between the logarithm of conductivity ln(σ) and the degree of hydration , has been found:
ln(σ)=Av−Bv
10.
Sverine Gomes Nathalie Trannoy Philippe Grossel Franoise Depasse Claudine Bainier Daniel Charraut 《International Journal of Thermal Sciences》2001,40(11):1794
The used Scanning Thermal Microscopy (SThM) probe is a thin Pt resistance wire acting as a heat source and as a detector simultaneously. Its energetic balance is investigated by the study of the temperature profile along the probe. A theoretical approach of the measurement, based on this investigation, is then proposed. Simulations with this modelling are shown to predict how the heat, electrically produced in the probe, is dissipated in the probe-sample system. In particular, it is shown that the steady-state of conduction losses to the thermal element support varies versus the thermal conductivity of the sample and can lead to bad interpretations of the measurement. 相似文献