Developing maintainable expert systems using case-based reasoning

Abstract: Maintainability problems associated with traditional software systems are exacerbated in rule-based systems. The very nature of that approach — separation of control knowledge and data-driven execution — hampers maintenance. While there are widely accepted techniques for maintaining conventional software, the same is not true for rule-based systems. In most situations, both a knowledge engineer and a domain expert are necessary to update the rules of a rule-based system. This paper presents, first, an overview of the software engineering techniques and object-oriented methods used in maintaining rule-based systems. It then discusses alternate paradigms for expert system development. The benefits of using case-based reasoning (from the maintenance point of view) are illustrated through the implementation of a case-based scheduler. The main value of the scheduler is that its knowledge base can be modified by the expert without the assistance of a knowledge engineer. Since changes in application requirements can be given directly to the system by the expert, the effort of maintaining the knowledge base is greatly reduced.     

Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery

The coevolution of genomics and proteomics has led to advancements in the field of diagnosis and molecular mechanisms of disease. Proteomics is now stepping into the field of obstetrics, where early diagnosis of pregnancy complication such as preeclampsia (PE) is imperative. PE is a multifactorial disease characterized by hypertension with proteinuria, which is a leading cause of maternal and neonatal morbidity and mortality occurring in 5-7% of pregnancies worldwide. This review discusses the probable molecular mechanisms that lead to PE and summarizes the proteomics research carried out in understanding the pathogenicity of PE, and for identifying the candidate biomarker for diagnosis of the disease.     

Regional Climate Simulations on EU-INDIA Grid Infrastructures: Methodologies and Performance

In this paper, we present a possible approach to use different Grid infrastructures across Europe and India for regional climate simulations and discuss in details the advantages and limitations in using them. The application taken into consideration is the Regional Climate Model RegCM4, which has been recently re-written for making it more efficient and easier to be fully exploited on any kind of computational infrastructure. We describe here the methods applied to port this package on the Grid infrastructures made available by the EU-IndiaGrid project. We also discuss different approaches, the way to run the model on both European and Indian infrastructures and our promising approach to deal with data management issues. Use of RegCM on Grid infrastructure has further been compared with that on HPC resources. The domain worked upon for these tests is the South-Asia CORDEX domain, which is of great importance for the Indian Summer Monsoon. Our final conclusion is that, for certain class of experiments, RegCM4 model can be efficiently and easily integrated on Grid infrastructures, by means of the procedures described in this paper.     

An Information Services Architecture Model Based on Data Processing Stages

The author's simple model for an information services architecture is intended as a common frame of reference for both business and technical practitioners and groups various aspects of computing into four distinct layers based on data processing stages. These layers cover data life-cycle states from the time data is generated, stored, and analyzed, to when it's delivered and used. The model incorporates a link with typical enterprise architecture layers.     

Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia

The present prospective study examines proportions of maternal erythrocyte fatty acids across gestation and their association with cord erythrocyte fatty acids in normotensive control (NC) and preeclamptic pregnancies. We hypothesize that maternal fatty acid status in early pregnancy influences fetal fatty acid stores in preeclampsia. 137 NC women and 58 women with preeclampsia were included in this study. Maternal blood was collected at 3 time points during pregnancy (16–20th weeks, 26–30th weeks and at delivery). Cord blood was collected at delivery. Fatty acids were analyzed using gas chromatography. The proportions of maternal erythrocyte α‐linolenic acid, docosahexaenoic acid, nervonic acid, and monounsaturated fatty acids (MUFA) (p < 0.05 for all) were lower while total n‐6 fatty acids were higher (p < 0.05) at 16–20th weeks of gestation in preeclampsia as compared with NC. Cord 18:3n‐3, 22:6n‐3, 24:1n‐9, MUFA, and total n‐3 fatty acids (p < 0.05 for all) were also lower in preeclampsia as compared with NC. A positive association was observed between maternal erythrocyte 22:6n‐3 and 24:1n‐9 at 16–20th weeks with the same fatty acids in cord erythrocytes (p < 0.05 for both) in preeclampsia. Our study for the first time indicates alteration in maternal erythrocyte fatty acids at 16th weeks of gestation which is further reflected in cord erythrocytes at delivery in preeclampsia.     

Silver monoliths and their applications in catalytic reduction of 4-NP to 4-AP and sensing against As3+

Journal of Porous Materials - Silver monoliths using non-ionic surfactant Triton X-102 as reducing agent with and without additives such as Dextran and Ludox (SiNPs) were synthesized by modified...     

Magnetization Curve of Two-Dimensional Anti-ferromagnetic Solid 3He on Graphite

Two-dimensional anti-ferromagnetic solid ³He on graphite, so called 4/7 phase, is a highly frustrated magnetic system and its ground state is considered to be a gapless spin liquid. Then how is the behavior in high magnetic fields? We tried to observe the magnetization curve at around 1 mK in high magnetic fields up to 10 T, using a Faraday-type magnetometer. To eliminate a large background signal from graphite as a substrate and copper as a thermal link, a double gradient coil system is employed to produce opposite field gradients in two regions equidistant from the field center. Preliminary results of the 4/7 phase on graphite show no saturated magnetization even at 1 mK and 10 T, suggesting the existence of magnetization plateau.     

Parametric Study of Jatropha Seeds for Biodiesel Production by Reactive Extraction

The purpose of the present study was to reduce the cost and increase the efficiency of biodiesel production by reactive extraction (in situ) of Jatropha seeds. Oil from the seeds was extracted and reacted in a single step. Experimental studies have been carried out to maximize the yield of biodiesel by varying the reaction parameters viz. seed size (<0.85 mm to >2.46 mm), seed/solvent ratio (w/w) (1:2.6–1:7.8) and catalyst concentration (0.05–0.1 M). Under the optimized conditions: seed size (>2.46 mm), seed/solvent ratio (w/w) (1:7.8), catalyst concentration (0.1 M) and reaction time 1 h, approximately 98% conversion to biodiesel was achieved meeting International (ASTM) as well as National (BIS) specifications. The results were supported by HPLC analysis.