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排序方式: 共有196条查询结果,搜索用时 31 毫秒
1.
Antonio Mancini Carmine Bruno Edoardo Vergani Claudia dAbate Elena Giacchi Andrea Silvestrini 《International journal of molecular sciences》2021,22(4)
The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different mechanisms could contribute to hyperandrogenism and anovulation, which are the main features of the syndrome. Obesity and insulin-resistance are claimed as the principal factors contributing to the clinical presentation; in normal weight PCOS either, increased visceral adipose tissue has been described. However, their role is still debated, as debated are the biochemical markers linked to obesity per se. Oxidative stress (OS) and low-grade inflammation (LGI) have recently been a matter of researcher attention; they can influence each other in a reciprocal vicious cycle. In this review, we summarize the main mechanism of radical generation and the link with LGI. Furthermore, we discuss papers in favor or against the role of obesity as the first pathogenetic factor, and show how OS itself, on the contrary, can induce obesity and insulin resistance; in particular, the role of GH-IGF-1 axis is highlighted. Finally, the possible consequences on vitamin D synthesis and activation on the immune system are briefly discussed. This review intends to underline the key role of oxidative stress and low-grade inflammation in the physiopathology of PCOS, they can cause or worsen obesity, insulin-resistance, vitamin D deficiency, and immune dyscrasia, suggesting an inverse interaction to what is usually considered. 相似文献
2.
Gennaro Costagliola Vincenzo Deufemia Filomena Ferrucci Carmine Gravino 《Information and Computation》2003,187(2):209-245
Drawn symbolic pictures are an extension of drawn pictures obtained by associating a symbol from an alphabet to each point of the picture. In the paper we will address some new interesting issues derived from the introduction of the symbols and we will identify the conditions, which ensure the preservation of properties holding for drawn pictures in the setting of the proposed extension. 相似文献
3.
Laura Francesca Pisani Gian Eugenio Tontini Carmine Gentile Beatrice Marinoni Isabella Teani Nicoletta Nandi Pasquale Creo Emanuele Asti Luigi Bonavina Maurizio Vecchi Luca Pastorelli 《International journal of molecular sciences》2021,22(11)
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures. Cell lines and tissue samples underwent stimulation with rhIL-33. Proliferation was assessed by XTT and CFSE assays, migration by wound healing assay, and apoptosis by caspase 3/7 activity assay and annexin V assay. Cell cycle was analyzed by means of propidium iodine assay, and gene expression regulation was assessed by RT-PCR profiling. We found that IL-33 has an antiproliferative and proapoptotic effect on cancer cell lines, and it can stimulate proliferation and reduce apoptosis in normal epithelial cell lines. These effects were also confirmed by the analysis of cell cycle gene expression, which showed a reduced expression of pro-proliferative genes in cancer cells, particularly in genes involved in G0/G1 and G2/M checkpoints. These results were confirmed by gene expression analysis on bioptic and surgical specimens. The aforementioned results indicate that IL-33 may be involved in cell proliferation in an environment- and cell-type-dependent manner. 相似文献
4.
5.
Jian-Feng Cai Raymond H. Chan Carmine Di Fiore 《Journal of Mathematical Imaging and Vision》2007,29(1):79-91
Recently, a powerful two-phase method for restoring images corrupted with high level impulse noise has been developed. The
main drawback of the method is the computational efficiency of the second phase which requires the minimization of a non-smooth
objective functional. However, it was pointed out in (Chan et al. in Proc. ICIP 2005, pp. 125–128) that the non-smooth data-fitting
term in the functional can be deleted since the restoration in the second phase is applied to noisy pixels only. In this paper,
we study the analytic properties of the resulting new functional ℱ. We show that ℱ, which is defined in terms of edge-preserving
potential functions φ
α
, inherits many nice properties from φ
α
, including the first and second order Lipschitz continuity, strong convexity, and positive definiteness of its Hessian. Moreover,
we use these results to establish the convergence of optimization methods applied to ℱ. In particular, we prove the global
convergence of some conjugate gradient-type methods and of a recently proposed low complexity quasi-Newton algorithm. Numerical
experiments are given to illustrate the convergence and efficiency of the two methods.
相似文献
Carmine Di FioreEmail: |
6.
Phuong D. H. Nguyen Carmine T. Recchiuto Antonio Sgorbissa 《Journal of Intelligent and Robotic Systems》2018,89(1-2):27-49
Multirotors, among all aerial vehicles, are fundamental instruments in many situations, i.e. video recording of sport events, leisure, environmental monitoring before or after a disaster. In particular, in the context of environmental monitoring, the possibility of following a predetermined path while avoiding obstacles is extremely relevant. In this work, we propose a novel method for path definition in presence of obstacles, which describes a curve as the intersection of two surfaces. The planner, based on that path definition along with a Cascaded control architecture and utilizing a nonlinear control technique for both control loops (position and attitude), creates a framework to manipulate the multicopters’ behaviors. The method is demonstrated to be able to generate a safe path taking into account obstacles perceived in real-time and avoids collisions. These algorithms are embedded in a software package to control the flight of a fully autonomous AscTec Firefly hexacopter with two cameras and onboard processing capabilities. 相似文献
7.
Silvano Tosti Carmine Accetta Massimiliano Fabbricino Mirko Sansovini Ludovico Pontoni 《International Journal of Hydrogen Energy》2013
This work investigates the exploitation of olive mill wastewater (OMW) for producing hydrogen in a membrane reformer. 相似文献
8.
Evolution of the oxidative stability,bio‐active compounds and color characteristics of non‐thermally treated vegetable pâtés during frozen storage 下载免费PDF全文
9.
When designing very complex control strategy using hybrid technology, one usually faces the challenge of balancing effective realization of multi-control modeling with design simplicity. To better manage this difficulty we have used the agent paradigm as a simple and powerful bridge between asynchronous/distributed computation and Matlab environment. The proposed architecture has been used to design a complex hybrid control environment using multi-objective, fuzzy c-means, and genetic algorithms optimization to design hybrid control strategies suitable for the energy flows management on board of hybrid electric vehicles. 相似文献
10.
A.?PasqualoneEmail author F.?Caponio C.?Summo V.?Arapi 《European Food Research and Technology》2004,219(1):48-51
The long isolation of Albania and the scarcity of raw materials has traditionally led to the production of bread from crops other than wheat, like maize, which is the basic ingredient for maize bread (bukë misri), rye, which is used to prepare rye bread (bukë thekre), and chick-pea, used in chick-pea bread (bukë me qiqre). Today, these traditional breads are accompanied by other types, such as brown bread from soft wheat (bukë zize). In the present work, the traditional Albanian breads were characterised in order to assess their quality. The results obtained indicated that the protein content reflected the characteristics of the raw material used, being higher in the chick-pea bread and in bread made from high extraction rate wheat flour, while both fat and yellow pigment levels were higher in maize bread. A high humidity value was found in many of the breads examined, especially in maize bread, with consequent risks of moulds and a shortened shelf-life. 相似文献