艾哈迈德·阿德南·萨伊贡艺术中心,伊兹密尔,土耳其

<正>一座建筑的性能应当如何来衡量?除了通过统治当代建筑舆论的美学、技术以及经济价值来进行描述之外,我们还能够如何来阐释一座建筑,尤其是一座致力于庇护那些渴望展现自己的艺术家的建筑?有人会问成功的表演是如何实现的,表演者是如何进行伪装的、又是如何展现自己的?根据海德格尔的理论,当我们看不到钉子的时候,铁锤的表现才是成功的;钉子本身的出现通常表明出现了问题。     

The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency

Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in 8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an affected first degree relative. We have recently reported three mutations in the PROP1 gene that cause CPHD in human subjects. We report here the frequency of one of these mutations, a 301-302delAG deletion in exon 2 of PROP1, in 10 independently ascertained CPHD kindreds and 21 sporadic cases of CPHD from 8 different countries. Our results show that 55% (11 of 20) of PROP1 alleles have the 301-302delAG deletion in familial CPHD cases. Interestingly, although only 12% (5 of 42) of the PROP1 alleles of our 21 sporadic cases were 301-302delAG, the frequency of this allele (in 20 of 21 of the sporadic subjects given TRH stimulation tests) was 50% (3 of 6) and 0% (0 of 34) in the CPHD cases with pituitary and hypothalamic defects, respectively. Using whole genome radiation hybrid analysis, we localized the PROP1 gene to the distal end of chromosome 5q and identified a tightly linked polymorphic marker, D5S408, which can be used in segregation studies. Analysis of this marker in affected subjects with the 301-302delAG deletion suggests that rather than being inherited from a common founder, the 301-302delAG may be a recurring mutation.     

Role of apoptosis in testicular tissue damage caused by varicocele

PURPOSE: During the last few years there has been an increasing interest in evaluating quality of life (QOL) data regarding surgical treatment. METHODS: The present study comments the efficacy of laparoscopic antireflux surgery after required Nissen fundoplication of 70 patients. Therefore, the German Gastrointestinal Quality of Life Index (GIQLI) was used to query the patients preoperatively and three times after surgery up to 1 year. RESULTS: Preoperatively, we found a low general GIQLI score (mean 92.7 points), which increased 6 weeks postoperatively (116.8 points), 3 months (124.8) and 1 year (mean 123.9 points) significantly and is now comparable to the healthy population (122.6 points). CONCLUSION: It is our opinion that the efficacy of the treatment of gastroesophageal reflux disease with required Nissen fundoplication can also be documented and discussed by using QOL.     

Thermal modelling of end milling

Determination of the temperatures during machining is one of the most important challenges for accurate milling simulations. Coupled with excessive shearing, plastic deformation and friction in a small region of cutting, the temperatures in milling may have very significant impact on parts and tools such as dimensional errors, residual stresses and tool wear. Temperature exhibits a non-linear complex-modelling problem in milling process. In this article, for the first time, a novel thermal modelling is introduced for fast and accurate prediction of temperatures in end milling processes. A theoretical modelling approach and experimental validations are presented for various cutting conditions.     

Salt-Starch Interactions as Evidenced by Viscosity and Dielectric Property Measurements

Increasing the concentration of salt (NaCl) or starch in a salt-starch solution depressed the dielectric constant and loss factor relative to a pure salt solution, except for the loss factor when no salt was present. The addition of salt to a starch solution increased the viscosity. Both viscosity and dielectric properties were decreased by mechanical agitation and by action of amylase. Above 10% starch the decrease in dielectric loss was abrupt, corresponding to the increase in viscosity. The changes were hypothesized to be due to an interaction between salt and starch, either through direct binding of the salt, or indirectly through the increase in viscosity.     

The determination of aflatoxins in spices by immunoaffinity column extraction using HPLC

Seventy‐five samples of different spices marketed in Turkey were purchased from bazaars, herbal shops and supermarkets. Equal amounts of paprika, chilli, black peppers and cumin were purchased and used to test and compare the amount of aflatoxin contamination. Two different analytical methods were examined for their efficacy by adding a known amount of aflatoxin to the blank samples of paprika. Twenty‐seven paprika, all the chilli powder and four ground black pepper samples were contaminated with aflatoxin B₁ in the range of 0.5–116.4, 1.6–80.4 and 0.3–1.2 μg kg^?1 respectively. Twenty‐three (30%) paprika and chilli powder samples were above the regulatory limits used in the European Union. No aflatoxin contamination was detected in the cumin samples at a detection limit of 0.2 μg kg^?1.     

Individual and Combined Use of Rosemary and Origanum in Soybean Oil as Natural Antioxidants

Dried rosemary and origanum were added to soybean oil, individually and in combination, to determine their effect on the oxidation stability of soybean oil. Samples were stored at two different temperatures (60°C and room temperature) and oxidation was determined by peroxide value and conjugated diene value. The treated soybean oil samples showed evidence of antioxidant activity at 60°C and at room temperature. Furthermore, it was observed that the herbs stored under room temperature had a higher activity compared to those stored at 60°C.     

Increased aflatoxin contamination of dried figs in a drought year

Dried figs (4917 samples) destined for export from Turkey to the European Union were collected between September and December during the very dry crop year of 2007 and tested for aflatoxins B₁, B₂, G₁ and G₂ by immunoaffinity column clean-up and reverse-phase high-performance liquid chromatography (RP-HPLC). While 32% of the samples contained detectable levels of total aflatoxins, 9.8% of them exceeded the European Union limits. Aflatoxin levels were in the range of 0.2–259.46 µg kg^?1 and 2.04–259.46 µg kg^?1 for all samples and samples that exceeded the limits, respectively. A substantial increase in the incidence of aflatoxins was observed in 2007 compared with previous years, most likely due to the drought stress, high temperatures and low relative humidity encountered during the period from January to September of that year. In 2007, the mean temperature was 1–2°C higher, there was 300 mm less total rain, and the mean relative humidity was 10–15% lower than in 2002–06. The average concentration of individual aflatoxins present in the samples was quantified to determine whether the drought conditions promoted certain types of aflatoxins. Among the contaminated samples, aflatoxin B₁ occurred in 97% of the contaminated samples, followed by G₁ in 47%, B₂ in 24%, and G₂ in 6% of samples. Concentrations of individual aflatoxins exhibited great variability among the samples but were not significantly different from those reported in previous studies, which were conducted under conditions without drought and high temperatures.