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Milena Jankovic Ivana Novakovic Dejan Nikolic Jasmina Mitrovic Maksic Slavko Brankovic Ivana Petronic Dragana Cirovic Sinisa Ducic Mirko Grajic Dragana Bogicevic 《International journal of molecular sciences》2021,22(9)
Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN. 相似文献
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Anita Valmarska Dragana Miljkovic Nada Lavrač Marko Robnik-Šikonja 《Journal of Intelligent Information Systems》2018,51(2):301-337
Parkinson’s disease is a neurodegenerative disorder that affects people worldwide. Careful management of patient’s condition is crucial to ensure the patient’s independence and quality of life. This is achieved by personalized treatment based on individual patient’s symptoms and medical history. The aim of this study is to determine patient groups with similar disease progression patterns coupled with patterns of medications change that lead to the improvement or decline of patients’ quality of life symptoms. To this end, this paper proposes a new methodology for clustering of short time series of patients’ symptoms and prescribed medications data, and time sequence data analysis using skip-grams to monitor disease progression. The results demonstrate that motor and autonomic symptoms are the most informative for evaluating the quality of life of Parkinson’s disease patients. We show that Parkinson’s disease patients can be divided into clusters ordered in accordance with the severity of their symptoms. By following the evolution of symptoms for each patient separately, we were able to determine patterns of medications change which can lead to the improvement or worsening of the patients’ quality of life. 相似文献
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Milena Premović Milica Tomović Duško Minić Dragan Manasijević Dragana Živković Vladan Ćosović Vladan Grković Aleksandar Đorđević 《Journal of Materials Engineering and Performance》2017,26(6):2491-2501
Ternary Al-Ag-Ga system at 200 °C was experimentally and thermodynamically assessed. Isothermal section was extrapolated using optimized thermodynamic parameters for constitutive binary systems. Microstructure and phase composition of the selected alloy samples were analyzed using light microscopy, scanning electron microscopy combined with energy-dispersive spectrometry and x-ray powder diffraction technique. The obtained experimental results were found to be in a close agreement with the predicted phase equilibria. Hardness and electrical conductivity of the alloy samples from four vertical sections Al-Ag80Ga20, Al-Ag60Ga40, Ag-Al80Ga20 and Ag-Al60Ga40 of the ternary Al-Ag-Ga system at 200 °C were experimentally determined using Brinell method and eddy current measurements. Additionally, hardness of the individual phases present in the microstructure of the studied alloy samples was determined using Vickers microhardness test. Based on experimentally obtained results, isolines of Brinell hardness and electrical conductivity were calculated for the alloys from isothermal section of the ternary Al-Ag-Ga system at 200 °C. 相似文献
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Lactic acid production on a combined distillery stillage and sugar beet molasses substrate 下载免费PDF全文
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Gvozden S. Tasić Uroš Lačnjevac Marijana M. Tasić Milica Marčeta Kaninski Vladimir M. Nikolić Dragana L. Žugić Vladimir D. Jović 《International Journal of Hydrogen Energy》2013
In this study, different Ni–W coatings, obtained by cheap and technologically simple electrodeposition method, were examined as potential electrocatalysts for the hydrogen evolution reaction (HER). All electrodepositions were done on a Ni mesh substrate from ammoniacal-citrate bath containing different concentrations of Na2WO4. The influence of deposition parameters, such as deposition current density, pH and composition of ammoniacal-citrate bath on electrocatalytic activity of obtained Ni–W coatings toward HER was examined by polarization curve measurements in 6 M KOH at room temperature. The morphology and tungsten content of the Ni–W coatings were investigated by means of SEM and EDS analysis. All investigated electrodes have shown high electrocatalytic activity for the HER. The samples obtained at higher deposition current densities had the lowest overvoltage for the HER. It has been shown that the plating bath pH value is very important parameter in obtaining active coatings. Results of the analysis of polarization curves, morphology of deposited Ni–W coatings and the content of tungsten in the coatings, indicate that the surface roughness of the coatings is responsible for their catalytic activity towards HER. 相似文献
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Automatic Estimation of Multiple Target Positions and Velocities Using Passive TDOA Measurements of Transients 总被引:3,自引:0,他引:3
Dragana Carevic 《Signal Processing, IEEE Transactions on》2007,55(2):424-436
This paper considers the problem of the estimation of the motion parameters of multiple targets moving linearly in a three-dimensional (3-D) observation area contaminated by clutter. The measurements are limited to time differences of arrival (TDOAs) of short-duration acoustic emissions, or transients, generated by the targets. This problem can arise in situations where the level of continuous broadband target-related noise is very low. Owing to the fact that transient emissions are nonstationary and can have low signal-to-noise ratio (SNR), the corresponding TDOA measurement errors are usually non-Gaussian. Therefore, Gaussian mixture distributions are used to appropriately model these errors. An iterative maximum-likelihood optimization technique based on a modified deterministic annealing expectation-maximization (MDAEM) algorithm is applied to this problem. In each iteration, the algorithm uses a nonlinear least-squares (LS) technique in computing the motion parameters for each target. It generalizes the variance deflation method previously used for the initialization of target tracking algorithms and increases the possibility of attaining a globally optimal solution for random initial conditions. Simulation results are presented for several different numbers of targets, clutter densities, and probabilities of gross error of the target related measurements and are found to be comparable to the estimates obtained when the measurement-to-target assignments are exactly known 相似文献
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Marija Kuzmanovic Gordana Savic Bisera Andric Gusavac Dragana Makajic-Nikolic Biljana Panic 《Expert systems with applications》2013,40(10):4083-4089
In recent years, the need for greater accountability and improvement in teaching’s quality has become a major issue in higher education. The results of student evaluation of teaching are increasingly used to make judgments about teaching quality, career advancement, and the funding of teaching itself. An important component of any such student evaluation is the communication of rating results in a manner that allows for fair and meaningful interpretations and comparisons of results by a wide range of evaluation users. In this paper, an approach for a more objective evaluation of university teachers is proposed, one which is based on previously obtained conjoint analysis data concerning criteria importance from a student’s point of view. Therein, an illustrative example is given to demonstrate the efficiency and practical usage of such a proposed approach. 相似文献
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