Microbial susceptibility of various polymers and evaluation of thermoplastic elastomers with antimicrobial additives

The incursion of microbial growth on polymeric products can deteriorate their performance and lead to the development of undesirable staining and odors. A growing trend in the industry has aimed to reduce microbial populations on high-touch surfaces via the use of antimicrobials to protect material aesthetics and durability or to prevent the spread of pathogenic microorganisms. In this study, a variety of plastic substrates (30 unique polymer compounds), including poly(acrylonitrile-co-butadiene-co-styrene), poly(butylene terephthalate), poly(etherimide), various thermoplastic elastomers (TPEs), poly(carbonates), and poly(amides), were screened for susceptibility to microbial attack using American Society for Testing and Materials (ASTM) G21 (fungi susceptibility), Japanese Industrial Standard (JIS) Z2801, and modified ASTM E1428-15a (bacterial susceptibility) test standards. TPEs were determined to be most susceptible to microbial attack under the appropriate environmental conditions. Subsequent studies assessed the use of an antimicrobial additive, zinc pyrithione (ZPT), for potential efficacy in a variety of TPE blends for diverse target market applications. ZPT proved to be very effective in protecting TPEs, reducing Staphylococcus aureus and Escherichia coli populations by 99.9% or more in JIS Z2801 testing and inhibiting fungal growth (rating = 0) according to the ASTM G21 standard.     

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain. The brain’s utilization of ketones seems to depend mainly on the concentration in the blood, thus many dietary approaches such as ketogenic diets, ingestion of ketogenic medium-chain fatty acids or exogenous ketones, facilitate significant changes in the brain’s metabolism. Therefore, these approaches may ameliorate the energy crisis in neurodegenerative diseases, which are characterized by a deterioration of the brain’s glucose metabolism, providing a therapeutic advantage in these diseases. Most clinical studies examining the neuroprotective role of ketone bodies have been conducted in patients with Alzheimer’s disease, where brain imaging studies support the notion of enhancing brain energy metabolism with ketones. Likewise, a few studies show modest functional improvements in patients with Parkinson’s disease and cognitive benefits in patients with—or at risk of—Alzheimer’s disease after ketogenic interventions. Here, we summarize current knowledge on how ketogenic interventions support brain metabolism and discuss the therapeutic role of ketones in neurodegenerative disease, emphasizing clinical data.     

Multiservice allocation for multiaccess wireless systems

This paper discusses principles for allocating multiple bearer services onto different subsystems in multiaccess wireless systems. Based on the included subsystem's multiservice capacities, under certain constraints near-optimum subsystem service allocations that maximize combined multiservice capacity are derived through simple optimization procedures. These favorable service allocations are either extreme points where services, as far as possible, are allocated to the subsystems best at supporting them, or they are characterized by the relative efficiency of supporting services being equal in all subsystems. The consequences of this include that services should typically be mixed in subsystems with convex capacity regions and isolated in subsystems with concave capacity regions. Simple user assignment algorithms based on this are also discussed. Additionally, illustrating the main findings of the analysis, some system examples are given, including a case study with combined global system for mobile communications (GSM) and wideband code-division multiple-access (WCDMA) systems. The gain of using the proposed service allocation principles compared to a reference case of maintaining equal service mixes in all subsystems depends on the shape of the subsystem capacity regions; the more different the capacity regions, the larger the gain. In the GSM and WCDMA case study, capacity gains of up to 100% in terms of supported data users for a fixed voice traffic load are achieved.     

A body-shadowing model for indoor radio communication environments

Deterministic propagation prediction methods proposed for indoor radio are useful for estimating the average propagation loss in real environments, which usually have complicated geometries. On the other hand, these methods generally fail to accommodate human body shadowing, which is a significant propagation effect in indoor picocells. Several empirical models to describe body shadowing have been reported. However, to our knowledge, no appropriate model that can be used in combination with deterministic propagation prediction methods has been provided in the literature. In this paper, a new practical model is introduced, which provides a way to estimate body-shadowing effects deterministically with the existing ray-determination methods. The detailed procedure to combine our body-shadowing model with the ray-determination methods is described. Several examples are shown applying the procedure to a simple office layout     

Microstructural Characterization of Cofired Tungsten-Metallized High-Alumina Electronic Substrates

Microstructural characterization of a high-Al₂O₃ substrate containing cofired thick-film tungsten metallization, with particular emphasis on the metal/ceramic interface, was conducted. The substrate contained tabular Al₂O₃ grains surrounded by a continuous calcium magnesium aluminum silicate glass containing particles of monoclinic ZrO₂ and reduced rutile (TiO_{2- x} ). The metal/ceramic adhesion was caused by mechanical interlocking between the W and Al₂O₃ grains by the glass phase which penetrated the porous W layers during sintering; there was no interfacial reaction or diffusion zone. The mechanical properties of the W metallization did not limit interfacial strength. Heat treatments of the substrate at 1400 K in air and under vacuum resulted in the devitrification of the intergranular glass. The most abundant devitrification product was anorthite (CaAl₂Si₂O₈), accompanied by magnesium aluminate titanate, magnesium aluminate spinel, α-cristobalite (SiO₂), and α-cordierite (Mg₂Al₄Si₅O₁₈). In addition, small rutile particles precipitated within the Al₂O₃ grains.     

Industry 4.0 as a Cyber-Physical System study

Advances in computation and communication are taking shape in the form of the Internet of Things, Machine-to-Machine technology, Industry 4.0, and Cyber-Physical Systems (CPS). The impact on engineering such systems is a new technical systems paradigm based on ensembles of collaborating embedded software systems. To successfully facilitate this paradigm, multiple needs can be identified along three axes: (i) online configuring an ensemble of systems, (ii) achieving a concerted function of collaborating systems, and (iii) providing the enabling infrastructure. This work focuses on the collaborative function dimension and presents a set of concrete examples of CPS challenges. The examples are illustrated based on a pick and place machine that solves a distributed version of the Towers of Hanoi puzzle. The system includes a physical environment, a wireless network, concurrent computing resources, and computational functionality such as, service arbitration, various forms of control, and processing of streaming video. The pick and place machine is of medium-size complexity. It is representative of issues occurring in industrial systems that are coming online. The entire study is provided at a computational model level, with the intent to contribute to the model-based research agenda in terms of design methods and implementation technologies necessary to make the next generation systems a reality.     

Leveraging Values in Global Organizations: Premises,Paradoxes and Progress

In this focused issue on the theme of “Leveraging Values in Global Organizations”, we highlight several prevalent themes on national, organizational and individual values in the literature. We argue that many premises in the literature have been accepted as fact; yet there are still many avenues open to exploration. We present several paradoxes that are often overlooked or lead to inconsistencies in the literature on values. The five articles in this focused issue address these premises and paradoxes, presenting new challenges and opportunities, providing progress and paving the way for future research on leveraging values in global organizations. The selected articles explore values with respect to international alliances and subsidiaries of multinational organizations at the organizational level, among global managers at the group level, and among employees and inpatriates at the individual level of analysis. We trust that readers of this issue will agree that the articles provide novel insights into key issues in the established, yet dynamic, field of research on values in the context of global organizations.     

Pressure sounding of the middle atmosphere from ATMOS solar occultation measurements of atmospheric CO(2) absorption lines

A method for retrieving the atmospheric pressure corresponding to the tangent point of an infrared spectrum recorded in the solar occultation mode is described and applied to measurements made by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier-transform spectrometer. Tangent pressure values are inferred from measurements of isolated CO(2) lines with temperature-insensitive strengths by measuring the slant-column CO(2) amount and by adjusting the viewing geometry until the calculated column matches the observed column. Tangent pressures are determined with a spectroscopic precision of l%-3%, corresponding to a tangent-point height precision of 70-210 m. The total uncertainty is limited primarily by the quality of the spectra and ranges between 4% and 6% (280-420 m) for spectra with signal-to-noise ratios of 300:1 and between 4% and 10% for spectra with signal-to-noise ratios of 100:1. The retrieval of atmospheric pressure increases the accuracy of the retrieved-gas concentrations by minimizing the effect of systematic errors introduced by climatological pressure data, ephemeris parameters, and the uncertainties in instrumental pointing.