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1.
Rafaelle Spear Ludovic Boytard Renaud Blervaque Maggy Chwastyniak David Hot Jonathan Vanhoutte Bart Staels Yves Lemoine Nicolas Lamblin Fran?ois-René Pruvot Stephan Haulon Philippe Amouyel Florence Pinet 《International journal of molecular sciences》2015,16(5):11276-11293
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with marked changes in the cellular composition of the aortic wall. This study aims to identify microRNA (miRNA) expression in aneurysmal inflammatory cells isolated by laser microdissection from human tissue samples. The distribution of inflammatory cells (neutrophils, B and T lymphocytes, mast cells) was evaluated in human AAA biopsies. We observed in half of the samples that adventitial tertiary lymphoid organs (ATLOs) with a thickness from 0.5 to 2 mm were located exclusively in the adventitia. Out of the 850 miRNA that were screened by microarray in isolated ATLOs (n = 2), 164 miRNAs were detected in ATLOs. The three miRNAs (miR-15a-3p, miR-30a-5p and miR-489-3p) with the highest expression levels were chosen and their expression quantified by RT-PCR in isolated ATLOs (n = 4), M1 (n = 2) and M2 macrophages (n = 2) and entire aneurysmal biopsies (n = 3). Except for the miR-30a-5p, a similar modulation was found in ATLOs and the two subtypes of macrophages. The modulated miRNAs were then evaluated in the plasma of AAA patients for their potential as AAA biomarkers. Our data emphasize the potential of miR-15a-3p and miR-30a-5p as biomarkers of AAA but also as triggers of ATLO evolution. Further investigations will be required to evaluate their targets in order to better understand AAA pathophysiology. 相似文献
2.
In this work was investigated the effect of the addition of barium titanate (BaTiO3) on electrical properties of two chemically recyclable thermosets, polyhemiaminal (PHA) and polyhexahydro‐s‐triazine (PHT), both fabricated from 4,4′‐oxydianiline (ODA), an ether derivative of aniline and paraformaldehyde. Thermal and mechanical properties as well as chemical recyclability of the two polymers and their nanocomposites/nanodielectrics were also investigated. In addition, a quantitative analysis was conducted of the nanoparticle dispersion in the PHA‐/PHT‐based BaTiO3‐containing nanocomposites using transmission electron microscopy imaging and the nearest‐neighbor distance index and this index was used to analyze the investigated properties in connection with the proper mechanisms. Regarding the electrical properties for both neat polymers, conductivity values of the order of 10?8 S m?1 at 100 Hz were observed and dielectric constant values close to 2.80 for both polymers at 1 kHz. The addition of 0.5 wt% of BaTiO3 ferroelectric nanoparticles increased by about 44% the dielectric constant (1 kHz) and conductivity (102 Hz) of the PHA‐based nanocomposite. PHA and PHT exhibited glass transition temperature (Tg) values in the range 125–180 °C. An increase of 7 °C in Tg was observed after the incorporation of 0.5 wt% of BaTiO3 into PHA. Concerning the mechanical properties, values in the range 4.00–4.45 GPa for reduced modulus and 0.30–0.43 GPa for nanohardness for PHA and PHT polymers were observed. Independently of filler content or polymer matrix, both mechanical properties were enhanced after the addition of BaTiO3. The chemical recycling of PHA/PHT and all nanocomposites in the initial ODA reagent after sulfuric acid treatment was successfully characterized using the NMR and Fourier transform infrared spectroscopic techniques. © 2018 Society of Chemical Industry 相似文献
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Maimaitiaili Tayier Yunfeng Zhao Dengle Duan Rongge Zou Yunpu Wang Roger Ruan 《木材化学与工艺学杂志》2020,40(3):190-199
AbstractLignin biochar-catalytic depolymerization using biochar Fe-600, Fe-800, Ni-600, Ni-800 catalysts under microwave-heating (180?°C for 30?min) was explored in an ethanol/formic acid (1:1) media. Non-catalyst depolymerization was also studied and compared with the biochar-catalysts results. Characteristics of the bio-char catalysts were analyze by BET, XRD, and FT-IR. GPC, FT-IR, and MALDI-TOF MS spectrometry were also used to characterize the depolymerization products. The experimental results showed that the SBET, Vt, and Vmec and average pore diameter of the biochars are considerably dependent on the preparation temperature and type of cation (Ni2+ or Fe3+). The maximum yield of bio-oil product was obtained as 85?wt% with the addition of biochar Ni-600 and the total amount of oligomers or monomers with a molecular weight of 164 to 446 reaches 80.4%. 相似文献
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Christian Stephan Bernd 《AEUE-International Journal of Electronics and Communications》2006,60(1):20-24
Security for ad hoc network environments has received a lot of attention as of today. Previous work has mainly been focussing on secure routing, fairness issues, and malicious node detection. However, the issue of introducing and conserving trust relationships has received considerably less attention. In this article, we present a scalable method for the use of public key certificates and their revocation in mobile ad hoc networks (MANETs). With the LKN-ad hoc security framework (LKN-ASF) a certificate management protocol has been introduced, bringing PKI technology to MANETs. In addition a performance analysis of two different revocation approaches for MANETs will be presented. 相似文献
7.
This work examines the correlation between the 1H‐NMR T2 relaxation constant and the mechanical properties of aged crosslinked polyolefin cable insulation. T2 experiments on unswollen samples could not differentiate between unaged and highly aged materials; all exhibited 1H T2 constants of approximately 0.5 ms. To accentuate the effects of aging, samples were swollen in various solvents. Unaged samples had T2 values of approximately 15 ms in good solvents. With thermal aging, T2 values decreased as the ultimate tensile elongation decreased. However, the correlation between T2 and elongation differed for samples irradiated with high‐energy radiation and for materials aged above versus below the crystalline melting temperature. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 2578–2582, 2003 相似文献
8.
Marginal costs of electricity vary by time and location. In the past, researchers attributed the variations to factors related to electricity generation and transmission. These authors, however, have not analyzed possible variations in marginal distribution capacity costs (MDCC). The objectives of this paper are:
- 1. (i) to show that large MDCC variations are due to the dispersion in distribution capital expenditures by time and space,
- 2. (ii) to propose a method for quantifying the area- and time-specific MDCC in the presence of lumpy investments, and
- 3. (iii) to compare our MDCC estimates to those commonly used in the electric utility industry.
9.
Eich (1985) recently presented a distributed memory model in which the pattern of results used to support the levels-of-processing view of Craik and Lockhart (1972) was modeled by different degrees of similarity between the encoding context and the to-be-recalled item. We report two experiments in which both phonemic and semantic similarity were varied between pairs of words and incidental acquisition (rhyme vs. category judgments) was varied across the same pairs of items. In both experiments the manipulation of the acquisition task produced a difference in cued-recall performance for positive and negative rhyme and category judgments. Recall was better following a category encoding decision than following a rhyme decision. This difference was independent of the effects of similarity, which demonstrated that Eich's (1985) assumptions regarding the effects of similarity are not sufficient to account for the differences resulting from the manner in which subjects encode information. An alternative method of modeling the levels-of-processing effect within the framework of distributed memory models is proposed. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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