A data-driven digital-twin prognostics method for proton exchange membrane fuel cell remaining useful life prediction

Prognostics and health management of proton exchange membrane fuel cell (PEMFC) systems have driven increasing research attention in recent years as the durability of PEMFC stack remains as a technical barrier for its large-scale commercialization. To monitor the health state during PEMFC operation, digital twin (DT), as a smart manufacturing technique, is applied in this paper to establish an ensemble remaining useful life prediction system. A data-driven DT is constructed to integrate the physical knowledge of the system and a deep transfer learning model based on stacked denoising autoencoder is used to update the DT with online measurement. A case study with experimental PEMFC degradation data is presented where the proposed data-driven DT prognostics method has applied and reached a high prediction accuracy. Furthermore, the predicted results are proved to be less affected even with limited measurement data.     

Kinetic analysis of cellular internalization and expulsion of unstructured D-chirality cell penetrating peptides

Most cell penetrating peptides (CPPs) are unstructured and susceptible to proteolytic degradation. One alternative is to incorporate D-chirality amino acids into unstructured CPPs to allow for enhanced uptake and intracellular stability. This work investigates CPP internalization using a series of time, concentration, temperature, and energy dependent studies, resulting in a three-fold increase in uptake and 50-fold increase in stability of D-chirality peptides over L-chirality counterparts. CPP internalization occurred via a combination of direct penetration and endocytosis, with a percentage of internalized CPP expelling from cells in a time-dependent manner. Mechanistic studies identified that cells exported the intact internalized D-chirality CPPs via an exocytosis independent pathway, analogous to a direct penetration method out of the cells. These findings highlight the potential of a D-chirality CPP as bio-vector in therapeutic and biosensing applications, but also identify a new expulsion method suggesting a relationship between uptake kinetics, intracellular stability, and export kinetics.     

A meta-heuristic approach to solve a JIT scheduling problem in hybrid flow shop

In this paper we address a hybrid flow shop scheduling problem considering the minimization of the sum of the total earliness and tardiness penalties. This problem is proven to be NP-hard, and consequently the development of heuristic and meta-heuristic approaches to solve it is well justified. So, we propose an ant colony optimization method to deal with this problem. Our proposed method has several features, including some heuristics that specifically take into account both earliness and tardiness penalties to compute the heuristic information values. The performance of our algorithm is tested by numerical experiments on a large number of randomly generated problems. A comparison with solutions performance obtained by some constructive heuristics is presented. The results show that the proposed approach performs well for this problem.     

Bioactive and Physicochemical Properties of Persimmon as Affected by Drying Methods

In this study, the effects of three different drying methods (freeze drying, oven drying, and vacuum oven drying) on bioactive (total phenolics, total flavonoids, condensed tannin and total hydrolyzable tannin contents, antiradical activity, and antidiabetic activity) and some physicochemical (dry matter, ash, water activity (a _w ), color, protein, hydroxymethylfurfural, glucose and fructose content) properties of persimmon fruit were investigated. Simplex lattice mixture design methodology was applied to determine the best solvent mixture for the extraction of phenolics from the samples. It was found that the mixture of acetone:water at the ratio of 50:50 % (v/v) was the best solvent mixture for the extraction. The persimmon powder sample obtained from freeze drying showed significantly (p <0.05) higher bioactivity values than oven- and vacuum-oven-dried samples. Antiradical activity changed significantly depending on the drying method employed and it was superior in freeze-dried samples than that of the other drying methods.     

Synthesis,characterization and thermal behaviors of polymers containing organosilicon groups

Various bis(silyl)ethenyl groups were attached to the aromatic ring of poly(α-methylstyrene) via Peterson olefination reaction of (RMe₂Si)₃CLi (R = H, Me and Ph) with formylated poly(α-methylstyrene) (Pα-MS-CHO) to give poly(α-methylstyrene)-co-[2,2-bis(silyl)ethenyl(α-methylstyrene)] as functionalized poly(α-methylstyrene) (Pα-MS-SiMe₂H, Pα-MS-SiMe₃ and Pα-MS-SiMe₂Ph). The trimethylsilyl groups of Pα-MS-SiMe₃ have been converted to 2,2-dibromoethenyl and epoxybis(silanes) groups via NBS-based bromodesilylation and MCPBA-based epoxidation respectively. The thermal degradation behaviors of the polymers were studied using thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC).     

Effect of temperature on rheological characteristics of molasses: Modeling of apparent viscosity using Adaptive Neuro - Fuzzy Inference System (ANFIS)

In this study, the effect of temperature on the rheological characteristics of apricot and date molasses was studied separately. Rheological characteristics of both molasses were evaluated in the shear rate range of 0.1-100 s⁻¹ at different temperatures (10-40 °C). Power law model was used for the calculation of flow behavior index and consistency coefficients of molasses. Consistency coefficients of apricot and date molasses were in the range of 5.408-39.905 Pa sⁿ and 0.910-2.852 Pa sⁿ, respectively. Molasses samples showed a non-Newtonian flow behavior. The effect of temperature on apparent viscosity was described by Arrhenius equation and calculated activation energy at the shear rate of 54.2 s⁻¹ was 41.42 and 38.19 kJ/mol for apricot and date molasses, respectively. An efficient predictive model for apparent viscosity values of molasses was constructed using Adaptive Neuro - Fuzzy Inference System (ANFIS) and this model showed satisfactory prediction with high coefficient of determination (0.979-0.999) and low root mean squared error (0.12-0.46).     

Evaluating location management schemes for third generation mobile networks

Several strategies have been proposed recently to improve the performance of the IS-41 location management scheme. A forwarding pointers' strategy and a built-in memory strategy are proposed to reduce the signaling cost for location update and improve the IS-41 location update procedure. In this paper, we present a performance analysis of each strategy in an arbitrary time interval. In this analysis, users are classified by their call to mobility ratio which is defined as the call arrival rate divided by the mobility rate. We evaluate each of these strategies using this call to mobility ratio in order to come up with a set of recommendations that determine when each strategy is beneficial and for which class of users. We provide also a simplified analysis of the database loads generated by each strategy.     

Free markets and the marriage market: structural adjustment,gender relations,and working conditions among Dominican women workers

The relationship between economic conditions and marriage patterns in the Dominican Republic is analyzed using data collected in 1994 on women working in a free-trade zone. The author concludes that changes associated with structural adjustment appear to have contributed to a deterioration of the job market and a greater prevalence of female-headed households. It is shown that "structural adjustment increases the need for women to work, because of cuts in government programs, declining real wages, growing inflation, and a deterioration in male employment, which weakens the man's role as principal breadwinner and increases the importance and visibility of women's contribution to the household economy. This change in the gender composition of the labor force has encouraged some women to resist marriage and/or remarriage because the ?marriage market' of eligible men willing and able to support a family has been reduced, contributing to greater marital instability."