排序方式: 共有5条查询结果,搜索用时 0 毫秒
1
1.
2.
Chuda Chittasupho Amornrat Manthaisong Siriporn Okonogi Sarin Tadtong Weerasak Samee 《International journal of molecular sciences》2022,23(1)
Wound healing impairment due to a postponed, incomplete, or uncoordinated healing process has been a challenging clinical problem. Much research has focused on wound care, particularly on discovery of new therapeutic approaches for acute and chronic wounds. This study aims to evaluate the effect of the combination of quercetin and curcuminoids at three different ratios on the antimicrobial, antioxidant, cell migration and wound healing properties. The antioxidant activities of quercetin, curcuminoids and the mixtures were tested by DPPH and ABTS free radical scavenging assays. The disc diffusion method was performed to determine the antibacterial activities of quercetin, curcuminoids and the mixtures against S. aureus and P. aeruginosa. The cytotoxicity and cell migratory enhancing effects of quercetin, curcuminoids and the mixtures against human dermal fibroblasts were investigated by MTT assay, scratch assay and Transwell migration assay, respectively. The results showed the synergism of the quercetin and curcuminoid combination to inhibit the growth of S. aureus and P. aeruginosa, with the inhibition zone ranging from 7.06 ± 0.25 to 8.78 ± 0.38 mm, respectively. The DPPH free radical scavenging assay demonstrated that the combination of quercetin and curcuminoids yielded lower IC50 values (15.38–23.70 µg/mL) than curcuminoids alone (25.75 µg/mL). Quercetin and a 3:1 quercetin/curcuminoid mixture at non-toxic concentrations showed the ability to stimulate the migration of fibroblasts across the matrix, whereas only quercetin alone accelerated the wound closure of fibroblasts. In conclusion, the mixture of quercetin and curcuminoids at a 3:1 ratio was the best formulations for use in wound healing due to the antimicrobial, antioxidant and cell-migration-enhancing activities. 相似文献
3.
Mangosteen peel extract exhibits cellular antioxidant activity by induction of catalase and heme oxygenase‐1 mRNA expression 下载免费PDF全文
4.
5.
Weerasak Somkhunthot Watcharin Detkunthong Areerat Dawongsa Kitsana Lamsombat Chartchai Bunyattrakoon Sasima Kongmongkol 《Integrated ferroelectrics》2015,165(1):31-44
Thermoelectric minerals have been found at Loei Province, in the northeastern part of Thailand. Local mineral specimens were prepared in the powders and bulk solids form by crushing, calcination and annealing, pressure and sintering, cutting and polishing. Mineral samples were used to analyze the composition and phase, determine the thermoelectric property and efficiency, design and construct a thermoelectric generator. Chemical composition and phase identification of powder samples were analyzed by the x-ray fluorescence (XRF) and x-ray diffraction (XRD), respectively. XRF and XRD results indicated that the mineral samples comprised the SO3-CaO-SiO2-others, Fe2O3-SO3-SiO2-others, Fe2O3-SiO2-others and Fe2O3-SiO2-CuO-others. From the thermoelectric property and efficiency determinations, the p-SO3-CaO-SiO2-others, p-Fe2O3-SO3-SiO2-others, n-Fe2O3-SiO2-others and n-Fe2O3-SiO2-CuO-others bulks were found to exhibit the thermoelectric figure of merit in orders of 10?14, 10?11, 10?14 and 10?13 K?1, respectively. A fabricated thermoelectric generator made from ten pairs of p-Fe2O3-SO3-SiO2-others and n-Fe2O3-SiO2-CuO-others legs that can be provided the open circuit voltage and short circuit current up to 48.30 mV and 0.14 μA for a temperature difference of 39.80 K at room temperature, respectively. While the internal resistance decreased and reached a value of 665 kΩ. 相似文献
1