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排序方式: 共有55条查询结果,搜索用时 31 毫秒
1.
Food Science and Biotechnology - MV was reported to have beneficial effects in ameliorating insulin resistance in db/db mice, but the intrinsic mechanisms for glucose homeostasis are unclear. This... 相似文献
2.
Min-Kyung Kang Soo-Il Kim Su Yeon Oh Woojin Na Young-Hee Kang 《International journal of molecular sciences》2020,21(22)
Podocyte injury inevitably results in leakage of proteins from the glomerular filter and is vital in the pathogenesis of diabetic nephropathy (DN). The underlying mechanisms of podocyte injury facilitate finding of new therapeutic targets for DN treatment and prevention. Tangeretin is an O-polymethoxylated flavone present in citrus peels with anti-inflammatory and antioxidant properties. This study investigated the renoprotective effects of tangeretin on epithelial-to-mesenchymal transition-mediated podocyte injury and fibrosis through oxidative stress and hypoxia caused by hyperglycemia. Mouse podocytes were incubated in media containing 33 mM glucose in the absence and presence of 1–20 μM tangeretin for up to 6 days. The in vivo animal model employed db/db mice orally administrated with 10 mg/kg tangeretin for 8 weeks. Non-toxic tangeretin inhibited glucose-induced expression of the mesenchymal markers of N-cadherin and α-smooth muscle actin in podocytes. However, the reduced induction of the epithelial markers of E-cadherin and P-cadherin was restored by tangeretin in diabetic podocytes. Further, tangeretin enhanced the expression of the podocyte slit diaphragm proteins of nephrin and podocin down-regulated by glucose stimulation. The transmission electron microscopic images revealed that foot process effacement and loss of podocytes occurred in diabetic mouse glomeruli. However, oral administration of 10 mg/kg tangeretin reduced urine albumin excretion and improved foot process effacement of diabetic podocytes through inhibiting loss of slit junction and adherenes junction proteins. Glucose enhanced ROS production and HIF-1α induction in podocytes, leading to induction of oxidative stress and hypoxia. Similarly, in diabetic glomeruli reactive oxygen species (ROS) production and HIF-1α induction were observed. Furthermore, hypoxia-evoking cobalt chloride induced epithelial-to-mesenchymal transition (EMT) process and loss of slit diaphragm proteins and junction proteins in podocytes, which was inhibited by treating submicromolar tangeretin. Collectively, these results demonstrate that tangeretin inhibited podocyte injury and fibrosis through blocking podocyte EMT caused by glucose-induced oxidative stress and hypoxia. 相似文献
3.
Ji-Won Jang Jae-Hyong Park Il-Jin Kim Jae-Hak Sim Seung-gun Yu Dong-Jin Lee Young-Hee Lee Sang-Hui Park Han-Do Kim 《应用聚合物科学杂志》2021,138(6):49788
In this study, a series of thermoresponsive cross-linked copolymer poly [N-isopropylacrylamide(NIPAm)-co-N-isopropylmethacrylamide(NIPMAm)] (P-M series samples: P-M-0, 10, 20, 30, 40, where numbers are co-monomer contents) hydrogels were prepared by free radical polymerization using the main monomer N-isopropylacrylamide (NIPAm), co-monomer N-isopropylmethacrylamide (NIPMAm), cross-linking agent N, N-methylenebisacrylamide, initiator (ammonium persulfate)/catalyst, and solvent water. In addition, a series of samples [P-G series samples: P-G-0, 10, 20, 30, 40, where numbers are co-solvent glycerol content) were prepared using P-M-40 as components and water/co-solvent glycerol as a mixed solvent. The effects of co-monomer NIPMAm and co-solvent glycerol contents on the lower critical solution temperature (LCST)/freezing temperature and light transmittance as function of temperature of the prepared copolymer gels were investigated. The resulting thermoresponsive polymer gels had LCSTs in the range of 17.9 to 38.7°C and freezing points in the range of 6.3 to −38.5°C. These gels are suitable materials for smart windows that are responsive to various environmental conditions. 相似文献
4.
Youngha Kim Sungkwan Kim Young-Ah Jeon Yunseok Kim Hanjong Paik Yangsoo Kim Sang-Chul Han Young-Hee Han Nyeon-Ho Jeong Tae-Hyun Sung Jong-In Hong Kwangsoo No 《Journal of Electroceramics》2006,17(2-4):1063-1067
YBa2Cu3Ox (Y123) superconducting films were fabricated on Cu substrates using a simple screen-printing method, from Cu-free powders
(Y2O3 and BaCO3). In the process, CuO, which causes superconducting properties of Y123 films to deteriorate, was formed on the film surface.
By varying the atomic ratio of Y to Ba (Y:Ba = 1:1∼1:4), the ratio needed to prevent CuO formation was found for the film
surface that had been heat-treated at 980∘C for 17 s. The film, with the ratio of Y to Ba (Y:Ba = 1:1), is reheat-treated at 930∘C for 9 min 30 s to form a superconducting Y123 phase. It was possible to prevent CuO formation by controlling the ratio of
Cu-free powders in the mixture and to fabricate YBCO superconductors on Cu substrates using a two-step heat-treatment. 相似文献
5.
Ahn Eunyeong Lee Jimin Jeon Young-Hee Choi Sang-Won Kim Eunjung 《Food science and biotechnology》2017,26(6):1693-1702
Food Science and Biotechnology - Despite with accumulating evidences on the anti-diabetic effects of mulberry branch (MB), the major active component for the activity has not been known. Oral... 相似文献
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We present a mass productive and reproducible assembly technique of a single bundle of single-walled carbon nanotubes (sb-SWNTs) using dielectrophoresis (DEP). Gold electrodes with 10 gaps made via microlithography were used to align the carbon nanotubes (CNTs). The magnitude and type of applied electric field were investigated to verify their effects on CNT assembly. The optimum assembling conditions in which sb-SWNTs could be positioned at a desired site were experimentally identified, and the characteristics of the assembled sb-SWNTs were evaluated from AFM, Raman spectroscopy, and I-V curve. This assembly method has potential for applications, such as gas sensors or electronic devices. 相似文献
9.
Young-Hee Kim Jae-Yoon Sim Hong June Park Jae-Ik Doh Kun-Woo Park Hyun-Woong Chung Jong-Hoon Oh Choon-Sik Oh Seung-Han Ahn 《Solid-State Circuits, IEEE Journal of》1997,32(1):79-85
The occasional power-on latch-up phenomenon of DRAM modules with a data bus shared by multiple DRAM chips on different modules was investigated and the circuit techniques for latch-up prevention were presented. Through HSPICE simulations and measurements, the latch-up triggering source was identified-to be the excessive voltage drop at the n-well pick-up of the CMOS transmission gate of read data latch circuit due to the short-circuit current which flows when the bus contention occurs during power-on. By extracting the HSPICE Gummel-Poon model parameters of the parasitic bipolar transistors of DRAM chips from the measured I-V and C-V data, HSPICE simulations were performed for the power-on latch-up phenomenon of DRAM chips. Good agreements were achieved between measured and simulated voltage waveforms. In order to prevent the power-on latch-up even when the control signals (RAS, GAS) do not track with the power supply, two circuit techniques were presented to solve the problem. One is to replace the CMOS transmission gate by a CMOS tristate inverter in the DRAM chip design and the other is to start the CAS-BEPORE-RAS (CBR) refresh cycle during power-on and thus disable all the Dout buffers of DRAM chips during the initial power-on period 相似文献
10.
Al-doped ZnO (AZO) is considered as an alternative to transparent conductive oxide materials. Patterning and achieving a stable surface are important challenges in the development and optimization of dry etching processes, which must be overcome for the application of AZO in various devices. Therefore, in this study, the etch rate and surface properties of an AZO thin film after plasma etching using the adaptive coupled plasma system were investigated. The fastest etch rate was achieved with a CF4/Ar ratio of 50:50 sccm. Regardless of the ratio of CF4 to Ar, the transmittance of the film in the visible region exceeded 80%. X-ray photoelectron spectroscopy analysis of the AZO thin film confirmed that metal-F bonding persists on the surface after plasma etching. It was also shown that F eliminates O vacancies. Consequently, the work function and bandgap energy increased as the ratio of CF4 increased. This study not only provides information on the effect of plasma on AZO thin film, but identifies the cause of changes in the device characteristics during device fabrication. 相似文献