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1.
Visibility of collaboration on the Web 总被引:14,自引:3,他引:11
The emerging influence of new information and communication technologies (ICT) on collaboration in science and technology
has to be considered. In particular, the question of the extent to which collaboration in science and in technology is visible
on the Web needs examining. Thus the purpose of this study is to examine whether broadly similar results would occur if solely
Web data was used rather than all available bibliometric co-authorship data. For this purpose a new approach of Web visibility
indicators of collaboration is examined. The ensemble of COLLNET members is used to compare co-authorship patterns in traditional
bibliometric databases and the network visible on the Web. One of the general empirical results is a high percentage (78%)
of all bibliographic multi- authored publications become visible through search of engines in the Web. One of the special
studies has shown Web visibility of collaboration is dependent on the type of bibliographic multi-authored papers. The social
network analysis (SNA) is applied to comparisons between bibliographic and Web collaboration networks. Structure formation
processes in bibliographic and Web networks are studied. The research question posed is to which extent collaboration structures
visible in the Web change their shape in the same way as bibliographic collaboration networks over time. A number of special
types of changes in bibliographic and Web structures are explained.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
2.
O'Keefe M.F. Atherton J.S. Bosch W. Burgess P. Cameron N.I. Snowden C.M. 《Semiconductor Manufacturing, IEEE Transactions on》2003,16(3):376-383
The establishment of a 150-mm (6-in) gallium arsenide (GaAs) facility is described together with the development of very high yielding and cost-effective semiconductor device technologies and a manufacturing capacity of over 40000 wafers/annum. The background to the demand for very high volumes of RF products for this market is discussed, together with the prospects for future growth. The paper describes recent process development by the utilization of a data-driven yield management system to support the delivery of high-quality RF products to customers. Finally, "end of line" DC and RF testing of finished 150-mm GaAs pHEMT foundry wafers is described, enabling scalar measurements of power, noise, and intermodulation products as well as vector measurements of S-parameters and noise parameters at frequencies of up to 40 GHz. 相似文献
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Bellens R. de Schrijver E. Van den Bosch G. Groeseneken G. Heremans P. Maes H.E. 《Electron Devices, IEEE Transactions on》1994,41(3):413-419
A continued fast interface trap generation is observed in n-channel MOS transistors after termination of the hot-carrier stress. The magnitude of this post-stress effect is strongly dependent on the conditions of the preceding stress, on the post-stress conditions and on the process parameters. For measurements at 293 K, a simple model is proposed which is based on the release of hydrogen by the thermal detrapping of holes, and which can explain the observed dependencies. The importance of the post-stress Dit-generation is illustrated for the case of dynamic stress conditions where it can lead to an apparently deviating degradation behavior 相似文献
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Laia Lidn Laura Lla-Hierro Mario Nuvolone Adriano Aguzzi Jesús vila Isidro Ferrer Jos Antonio del Río Rosalina Gavín 《International journal of molecular sciences》2021,22(10)
Tau protein is largely responsible for tauopathies, including Alzheimer’s disease (AD), where it accumulates in the brain as insoluble aggregates. Tau mRNA is regulated by alternative splicing, and inclusion or exclusion of exon 10 gives rise to the 3R and 4R isoforms respectively, whose balance is physiologically regulated. In this sense, one of the several factors that regulate alternative splicing of tau is GSK3β, whose activity is inhibited by the cellular prion protein (PrPC), which has different physiological functions in neuroprotection and neuronal differentiation. Moreover, a relationship between PrPC and tau expression levels has been reported during AD evolution. For this reason, in this study we aimed to analyze the role of PrPC and the implication of GSK3β in the regulation of tau exon 10 alternative splicing. We used AD human samples and mouse models of PrPC ablation and tau overexpression. In addition, we used primary neuronal cultures to develop functional studies. Our results revealed a paralleled association between PrPC expression and tau 4R isoforms in all models analyzed. In this sense, reduction or ablation of PrPC levels induces an increase in tau 3R/4R balance. More relevantly, our data points to GSK3β activity downstream from PrPC in this phenomenon. Our results indicate that PrPC plays a role in tau exon 10 inclusion through the inhibitory capacity of GSK3β. 相似文献
10.
Alfredo Jurez-Saldivar Elizabeth Barbosa-Cabrera Edgar E. Lara-Ramírez Alma D. Paz-Gonzlez Ana V. Martínez-Vzquez Virgilio Bocanegra-García Isidro Palos Nuria E. Campillo Gildardo Rivera 《International journal of molecular sciences》2021,22(11)
Infectious diseases caused by intestinal protozoan, such as Entamoeba histolytica (E. histolytica) and Giardia lamblia (G. lamblia) are a worldwide public health issue. They affect more than 70 million people every year. They colonize intestines causing primarily diarrhea; nevertheless, these infections can lead to more serious complications. The treatment of choice, metronidazole, is in doubt due to adverse effects and resistance. Therefore, there is a need for new compounds against these parasites. In this work, a structure-based virtual screening of FDA-approved drugs was performed to identify compounds with antiprotozoal activity. The glycolytic enzyme triosephosphate isomerase, present in both E. histolytica and G. lamblia, was used as the drug target. The compounds with the best average docking score on both structures were selected for the in vitro evaluation. Three compounds, chlorhexidine, tolcapone, and imatinib, were capable of inhibit growth on G. lamblia trophozoites (0.05–4.935 μg/mL), while folic acid showed activity against E. histolytica (0.186 μg/mL) and G. lamblia (5.342 μg/mL). 相似文献