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Pharmacodynamic Comparison of a Nasal Formulation of Verapamil and Intravenous and Oral Dosage Forms
The nasal route has been shown to be effective for the administration of numerous drugs in order to improve drug bioavailability. A nasal gel of verapamil hydrochloride was formulated and evaluated pharmacodynamically in humans, using electrocardiographic results, with comparison to oral and IV routes. Seven volunteers were involved in the study and the pharmacodynamic parameters were evaluated statistically. Experimental nasal gel showed similar pharmacodynamic results with the intravenous route, which is a hint to the reduction in verapamilinduced first-pass metabolism. However, oral route of administration showed a tendency of less efficacy. No reasonable effect of verapamil could be obtained with the placebo group. 相似文献
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Qingbin Cui Mehmet Emre Bayraktar Makarand Hastak Issam Minkarah 《Canadian Metallurgical Quarterly》2004,20(3):118-125
Since the introduction of warranty provisions in federal highway jobs, more and more state departments of transportation (DOTs) have considered the use of such provisions to protect their initial investment. This paper describes the pros and cons of warranty contracting in highway construction based on a survey of warranty practices in the United States. In particular, the need for state DOTs to buy a warranty for a well-built project is questioned. As an alternative, this paper introduces the warranty option, which gives the DOT the right to buy a warranty only if it becomes necessary at the end of construction. This option is exercised if the performance on site warrants it. This paper describes the mechanics of the warranty option and its advantages over the conventional warranty. A bid evaluation model is also developed for the warranty option approach. 相似文献
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The dispersive refractive index n(λ) and extinction coefficient k(λ) of CdS thin films were evaluated from spectrophotometric transmittance characteristic in the visible region. A method is presented to determine n(λ) and k(λ) in the region k2 n2, using wavelength and transmittance values. This method has been used for the investigation of the effect of the deposition rate on the optical properties of cadmium sulfide films. The refractive indices are found to depend on the deposition rate with values between 2.48 and 2.60. The energy gap of the samples is found to be independent of deposition rate with the value 2.44 eV. The real and imaginary parts of the dielectric constant have also been evaluated. 相似文献
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Cinkilic Emre Moodispaw Michael Zhang Jianyue Miao Jiashi Luo Alan A. 《Metallurgical and Materials Transactions A》2022,53(8):2861-2873
Metallurgical and Materials Transactions A - The use of secondary aluminum for structural components in the automotive industry is limited by the high Fe contents in recycled alloys which often... 相似文献
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Plasma glow‐discharge application is known as a technique to coat or modify the surfaces of various materials. In this study, the influence of oxygen rf‐plasma treatment on surface and bulk properties of a biological polyester, poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate), were studied by determining water content and water contact angle, and by using X‐ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The plasma‐treated films absorbed more water than the untreated film, and the absorbance increased with the total power applied. The water contact angles decreased and O/C atomic ratio increased on treatment, indicating that the material became more hydrophilic due to increases in the oxygen‐containing functional groups on the surface of the polymer. A direct relation could be observed when the O/C ratio was plotted against the total power applied (treatment duration × treatment power). SEM revealed a visual record of surface modification, the extent of which increased with increased total power. It was thus possible to alter the surface chemistry and relevant properties of the polymer film using oxygen plasma as a tool. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 1285–1289, 2003 相似文献
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We consider large N,T panel data models with fixed effects, a common factor allowing for cross‐section dependence, and persistent data and shocks, which are assumed fractionally integrated. In a basic setup, the main interest is on the fractional parameter of the idiosyncratic component, which is estimated in first differences after factor removal by projection on the cross‐section average. The pooled conditional‐sum‐of‐squares estimate is consistent but the normal asymptotic distribution might not be centred, requiring the time series dimension to grow faster than the cross‐section size for correction. We develop tests of homogeneity of dynamics, including the degree of integration, that have no trivial power under local departures from the null hypothesis of a non‐negligible fraction of cross‐section units. A simulation study shows that our estimates and tests have good performance even in moderately small panels. 相似文献
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Hamed Salimkhani Emre Erdem Selmiye Alkan Gursel Alp Yurum 《Journal of the American Ceramic Society》2021,104(8):4257-4271
Recently, lanthanides have been employed by researchers to examine their impact on the structure and properties of Li7La3Zr2O12 (LLZO) garnets. In this regard, we developed Europium oxide (Eu2O3) doped LLZO (Li7+δEuxLa3−δZr2−δO12−δ) solid electrolyte which demonstrates a cubic phase with the symmetry of Iad (No.230) at room temperature. In this investigation, different concentrations of Eu ranging from 0.1 to 0.6 atoms per formula unit (pfu) were doped into Li7La3Zr2O12 to evaluate the impact of Eu on the stability of the cubic phase and thereby the ionic conductivity. The results unveiled that upon doping Eu3+ ions, the Eu2+ state is also formed and is then self-doped into the structure in which Rietveld refinement coupled with XPS, EPR, and solid-state NMR suggests that Eu3+ ions most probably partially occupy Zr4+ (16a) site, the Eu2+ ions occupy La3+ (24d) site, and the Li+ ions occupy two different sites (24d and 96h). It was further found that such a site preference induces distortion at LaO8 polyhedrons opening up the neck for Li-ions diffusion, thereby enhancing the ionic conductivity. Moreover, it was revealed that Li-ions probably hop from 96h to 24d and then to 96h site to generate the Li-ion movement. Overall, by introducing Eu ions into the LLZO structure, an enhanced bulk ionic conductivity of 0.30 × 10−3 S/cm at 298 K with a minimum electronic conductivity of 2.547 × 10−9 S/cm at 298 K was achieved. 相似文献