Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP/HUS). Description of a series of 35 patients

Subsequent to the implementation of a severity marker stamp in case notes, an audit was performed in 86 admissions with acute asthma to a specialist centre over a 12 month period. Compared to previous audit the documentation of severity markers was significantly better (PEFR: 52% vs 83% p = 0.001, Respiratory rate: 44% vs 81% p = 0.001, ABG: 72% vs 80% p = 0.04, air entry: 58% vs 86% p = 0.001, speech: 27% vs 86% p = 0.001, exhaustion: 4% vs 86% p = 0.001). In contrast to the previous audit where no patient received FiO2 > 0.35, 66% of the cases in the repeat audit received FiO2 0.60 (p = 0.001). The mean duration of admission was five days and showed highest partial correlation (r = 0.6) to the time in hours for the pulse to fall to 80/min. Multiple linear regression showed that this was the only variable best predicting the duration of admission (R2 = 0.3). Admission pulse rate (p = 0.04) and serum K+ (p = 0.04) best discriminated between patients admitted for over and under five days. Logistic regression identified only the admission pulse as significant in calculating the odds of the patient staying in the hospital for > 5 days.     

Prevention of dark-cutting (DFD) beef in penned bulls at the abattoir

There is a large body of evidence indicating that activities associated with regrouping of bulls before slaughter, which leads to physical exhaustion mainly from mounting, are primary factors inducing dark-cutting (DFD) in beef. The aim of this study was to test several methods to control activity when regrouping cannot be avoided. Fifty bulls previously individually tied for at least 16 months were drafted into groups of five animals and released in a pen at the abattoir. After 18 to 22 h they were slaughtered. According to environmental conditions in the pen, the bulls were divided into four groups: Control group (n = 10, no experimentation); Electricity group (n = 10, an electric fence was constructed above the pen so that a mounting bull would receive an electric shock); Darkness group (n = 10, the whole stall was in darkness); and Combination group (n = 20, both treatments, of the electricity and darkness groups were applied). During the first hour of penning the behaviour of the bulls was videorecorded. After slaughter meat quality characteristics were measured. Dark-cutting was found in Control (70%), Electricity (30%) and Darkness (70%) groups, but not in the Combination group (0%). No treatment altered the repertoire of agonistic activity, but under the combined treatments the number of agonistic interactions was significantly lower than in any other group.     

Numerical calculation of digital curve length by using anchored discrete convolution

The paper presents a new method introducing an anchored discrete convolution for calculating the length of a digital curve. The method is based on discrete convolution by using convolution masks and point anchoring in the pixel. The use of ordinary convolution distorts the curve shape and gives large errors in length calculation. The advantage of anchoring is that it limits the point shifting into the pixel during the calculation of the curve length. The method is applied to an analytical arc and various calculations are performed. In addition different methods from the literature were compared and a real sample was tested.     

Automatic reconstruction of 3D human arm motion from a monocular image sequence

A model-based approach to reconstruction of 3D human arm motion from a monocular image sequence taken under orthographic projection is presented. The reconstruction is divided into two stages. First, a 2D shape model is used to track the arm silhouettes and second-order curves are used to model the arm based on an iteratively reweighted least square method. As a result, 2D stick figures are extracted. In the second stage, the stick figures are backprojected into the scene. 3D postures are reconstructed using the constraints of a 3D kinematic model of the human arm. The motion of the arm is then derived as a transition between the arm postures. Applications of these results are foreseen in the analysis of human motion patterns. Received: 26 January 1996 / Accepted: 17 July 1997     

Comparison of land surface emissivity and radiometric temperature derived from MODIS and ASTER sensors

This study compared surface emissivity and radiometric temperature retrievals derived from data collected with the MODerate resolution Imaging Spectroradiometer (MODIS) and Advanced Spaceborne Thermal Emission Reflection Radiometer (ASTER) sensors, onboard the NASA's Earth Observation System (EOS)-TERRA satellite. Two study sites were selected: a semi-arid area located in northern Chihuahuan desert, USA, and a Savannah landscape located in central Africa. Atmospheric corrections were performed using the MODTRAN 4 atmospheric radiative transfer code along with atmospheric profiles generated by the National Center for Environmental Predictions (NCEP). Atmospheric radiative properties were derived from MODTRAN 4 calculations according to the sensor swaths, which yielded different strategies from one sensor to the other. The MODIS estimates were then computed using a designed Temperature-Independent Spectral Indices of Emissivity (TISIE) method. The ASTER estimates were derived using the Temperature Emissivity Separation (TES) algorithm. The MODIS and ASTER radiometric temperature retrievals were in good agreement when the atmospheric corrections were similar, with differences lower than 0.9 K. The emissivity estimates were compared for MODIS/ASTER matching bands at 8.5 and 11 μm. It was shown that the retrievals agreed well, with RMSD ranging from 0.005 to 0.015, and biases ranging from −0.01 to 0.005. At 8.5 μm, the ranges of emissivities from both sensors were very similar. At 11 μm, however, the ranges of MODIS values were broader than those of the ASTER estimates. The larger MODIS values were ascribed to the gray body problem of the TES algorithm, whereas the lower MODIS values were not consistent with field references. Finally, we assessed the combined effects of spatial variability and sensor resolution. It was shown that for the study areas we considered, these effects were not critical.     

Scaling study of cavitation pitting from cavitating jets and ultrasonic horns

Cavitation erosion prediction and characterization of cavitation field strength are of interest to industries suffering from cavitation erosion detrimental effects. One means to evaluate cavitation fields and materials is to examine pitting rates during the incubation period, where the test sample undergoes localized permanent deformations shaped as individual pits. In this study, samples from three metallic materials, an Aluminum alloy (Al 7075), a Nickel Aluminum Bronze (NAB) and a Duplex Stainless Steel (SS A2205) were subjected to a vast range of cavitation intensities generated by cavitating jets at different driving pressures and by an ultrasonic horn. The resulting pitted sample surfaces were examined and characterized with a non-contact 3D optical scanner and the resulting damage computer-analyzed. A statistical analysis of the pit population and its characteristics was then carried out. It was found that the various cavitation field strengths can be correlated to the measured pit distributions and that two characteristic quantities: a characteristic number of pits per unit surface area and unit time, and a characteristic pit diameter or a characteristic pit depth can be attributed to a given “cavitation intensity level”. This characterization concept can be used in the future to study the cavitation intensity of the full scale and to develop methods of full scale predictions based on model scale erosion data.     

Material and velocity effects on cavitation erosion pitting

Cavitation erosion during the incubation period was investigated via pitting tests conducted on three different materials: an Aluminum alloy, a Nickel Aluminum Bronze alloy and a Duplex Stainless Steel. Pitting tests were conducted in a cavitation tunnel in the velocity range 45–90 m/s at a constant cavitation number. The test section was made of a straight nozzle 16 mm in diameter discharged into the radial 2.5 mm space between two flat walls. Cavitation appears in the form of a toroidal cavity attached to the nozzle exit and damage on the samples facing the nozzle is concentrated in a circular ring centered in the cavity closure region. The exposure time was adjusted to avoid pit overlapping. The material surface was examined using a conventional contact profilometer which allowed us to identify the pits, count them, and measure their main characteristics such as depth, surface area, and volume. From these the pitting rate, the coverage rate, and the depth of deformation rate were defined. Pits were classified according to their diameter. For all materials and operating conditions, pitting rate appears to follow an exponential law in relation to the pit diameter. This law depends upon two parameters only, which were identified as the coverage time τ (i.e. the time required for the surface to be covered by erosion pits) and a characteristic pit diameter δ, which corresponds to the pits whose contribution to the coverage process is the highest. Scaling laws for pitting were derived accounting for both material properties and flow velocity, and a procedure to make pitting test results non-dimensional is proposed. The influence of the material on pitting test results was analyzed. It is shown that the damage is not correlated in simple terms with the elastic limit determined from conventional tensile tests and it is conjectured that other parameters such as the strain rate might play a significant role and should be included in the analysis. The effect of flow velocity on both parameters τ and δ was analyzed and a classical power law was found for the influence of the flow velocity on pitting rate for all three materials. Finally, some analysis and discussion is given concerning distributions of pit volume and pit depth.     

Scientific collaboration of researchers and organizations: a two-level blockmodeling approach

Scientometrics - The development and successful implementation of R&D policies depends on understanding patterns of scientific collaboration (SC). Existing studies on SC typically focus on...     

Development of a solid self-microemulsifying drug delivery system (SMEDDS) for solubility enhancement of naproxen

Context: Comparative evaluation of liquid and solid self-microemulsifying drug delivery systems (SMEDDS) as promising approaches for solubility enhancement.

Objective: The aim of this work was to develop, characterize, and evaluate a solid SMEDDS prepared via spray-drying of a liquid SMEDDS based on Gelucire® 44/14 to improve the solubility and dissolution rate of naproxen.

Material and methods: Various oils and co-surfactants in combination with Gelucire® 44/14 were evaluated during excipient selection study, solubility testing, and construction of (pseudo)ternary diagrams. The selected system was further evaluated for naproxen solubility, self-microemulsification ability, and in vitro dissolution of naproxen. In addition, its transformation into a solid SMEDDS by spray-drying using maltodextrin as a solid carrier was performed. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were used to evaluate the physical characteristics of the solid SMEDDS obtained.

Results: The selected formulation of SMEDDS was comprised of Miglyol 812®, Peceol?, Gelucire® 44/14, and Solutol® HS 15. The liquid and solid SMEDDS formed a microemulsion after dilution with comparable average droplet size and exhibited uniform droplet size distribution. In the solid SMEDDS, liquid SMEDDS was adsorbed onto the surface of maltodextrin and formed smooth granular particles with the encapsulated drug predominantly in a dissolved state and partially in an amorphous state. Overall, incorporation of naproxen in SMEDDS, either liquid or solid, resulted in improved solubility and dissolution rate compared to pure naproxen.

Conclusion: This study indicates that a liquid and solid SMEDDS is a strategy for solubility enhancement in the future development of orally delivered dosage forms.