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1.
Male Swiss-Webster mice were rendered tolerant to morphine by subcutaneous implantation of a morphine pellet, each containing 75 mg morphine base, for 3 days. Mice implanted with placebo pellets served as controls. A high degree of tolerance to the analgesic effect of morphine developed as evidenced by decreased analgesic response to various doses of morphine. A selective kappa-opiate agonist, U-50,488H (8, 16 and 32 mg/kg, i.p.) produced dose-dependent analgesic and hypothermic effects in mice implanted with placebo pellets. A significant decrease in the analgesic and hypothermic effects of U-50,488H was observed in morphine tolerant mice as compared to placebo-treated mice. Mice were rendered tolerant to U-50,488H by injecting the drug (25 mg/kg, i.p.) twice daily for 4 days. Vehicle injected mice served as controls. Tolerance to the analgesic and hypothermic effects of U-50,488H in mice injected chronically with the drug was evidenced by the decreases in the intensity of these responses when compared to those observed in vehicle injected controls. Morphine produced a dose-dependent analgesic and hypothermic effects in mice injected chronically with vehicle but the intensity of these effects was significantly lower in mice injected chronically with U-50,488H. These results indicate that a substantial tolerance to analgesic and hypothermic effects of U-50,488H develops in morphine tolerant mice. The effect of chronic injections of U-50,488H on the binding of [3H]ethylketocyclazocine (EKC) and [3H]D-Ala2,MePhe4,Gly-ol5-enkephalin (DAMGO) to whole brain and spinal cord kappa- and mu-opiate receptors was determined.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
2.
Dietary CLA supplementation of pigs confers higher oxidative stability to Ciauscolo and Fabriano salami produced from their meat with no negative impact on the physico‐chemical,microbiological and sensorial characteristics 下载免费PDF全文
3.
M.S. Gravielle J.E. Miraglia 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2009,267(4):610-614
This work deals with the interference effects recently observed in grazing collisions of few-keV atoms with insulator surfaces. The process is studied within a distorted-wave method, the surface eikonal approximation, based on the use of the eikonal wave function and involving axial channeled trajectories with different initial conditions. The theory is applied to helium atoms impinging on a LiF(0 0 1) surface along the 〈1 1 0〉 direction. The role played by the projectile polarization and the surface rumpling is investigated. We found that when both effects are included, the proposed eikonal approach provides angular projectile spectra in good agreement with the experimental findings. 相似文献
4.
Roskowski A. M. Preble E. A. Einfeldt S. Miraglia P. M. Davis R. F. 《Journal of Electronic Materials》2002,31(5):421-428
High-resolution x-ray diffraction (XRD) and atomic force microscopy (AFM) of pendeo-epitaxial (PE) GaN films confirmed transmission
electron microscopy (TEM) results regarding the reduction in dislocations in the wings. Wing tilt ≤0.15° was due to tensile
stresses in the stripes induced by thermal expansion mismatch between the GaN and the SiC substrate. A strong D°X peak at
≈3.466 eV (full-width half-maximum (FWHM) ≤300 μeV) was measured in the wing material. Films grown at 1020°C exhibited similar
vertical [0001] and lateral [11
0] growth rates. Increasing the temperature increased the latter due to the higher thermal stability of the GaN(11
0). The (11
0) surface was atomically smooth under all growth conditions with a root mean square (RMS)=0.17 nm. 相似文献
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N. Tajabor M.R. Alinejad L. Motevalizadeh D. Fruchart E.K. Hlil D. Gignoux S. Miraglia 《Journal of Alloys and Compounds》2008,458(1-2):91-95
Magnetic properties and crystal structure of the hydrides of ferromagnetic compounds HoFe11−xCoxTi (x = 1, 2, 4, 6, 7, 11) are investigated. The crystal structure was determined by X-ray diffraction (XRD) analysis and the magnetization was measured in applied magnetic fields up to 10 T and at temperatures ranging from 5 K to room temperature. Results show that the crystal structure of the hydrides is the same as for parent compounds but with a moderate unit cell increase. Other properties such as saturation magnetization are affected by H insertion within the lattice. The effect of hydrogenation on magnetic anisotropy energy leads to disappearance of the FOMPs observed in the parent compounds. 相似文献
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S. Garrier A. Chaise P. de Rango P. MartyB. Delhomme D. FruchartS. Miraglia 《International Journal of Hydrogen Energy》2011,36(16):9719-9726
Magnesium hydrogenation being an exothermic reaction, the loading time of a tank is limited by heat extraction. The compaction of ball-milled MgH2 associated with Expanded Natural Graphite was used to improve the thermal conductivity of the resulting compacts. Taking advantage of these compacts, an intermediate scale tank (1.8 kg MgH2) cooled down by forced air circulation was designed. The absorption is initiated at 90 °C. Since the intrinsic kinetic is not the limiting factor, the hydrogen pressure does not affect the loading process. The loading time is strongly dependent on the cooling efficiency. However, beyond a given air flow rate it doesn’t decrease any more, the heat transfer being limited by the thermal conductivity of the compacted disks. During desorption, the maximum hydrogen flow (25 Nl/mn) is directly proportional to the thermal power of the heating system. The tank absorbs 1170 Nl, has a specific-energy of 270 W h/kg and a system volumetric-density of 42 gr/l. 相似文献
10.
A study was performed to evaluate the contamination by ochratoxin A in coffee beans. Twenty-nine samples of green coffee were collected from large lots of material by representative sampling. The analyses of green coffee samples showed a significantly high contamination percentage (58%) ranging from 0.2 to 15 micrograms/kg. Naturally and artificially contaminated samples were roasted at different operation times (5-6 min) to verify the percentage of destruction of the mycotoxin. The percentage ranged from 48% to 87% and from 90% to 100% in artificially and naturally contaminated samples respectively. The beverages prepared from artificially contaminated coffee using the most common types of coffee makers showed no residues of ochratoxin A. 相似文献