A parallel systems approach to universal receivers

The problem of communication over a channel with unknown characteristics is addressed. The true channel is from a known set of channels, but the transmitter and receiver do not know which of these channels is actually in effect. The goal of a universal receiver is to provide nearly optimal demodulation regardless of the channel that is actually in effect. A parallel receiver implementation is proposed for a universal scheme to cope with such uncertainty. The parallel system consists of a finite number of receivers with the property that, for each channel in the set, the performance of at least one of the receivers will be within a specified performance range. Data verification is accomplished by an appropriate coding system. Sufficient conditions for the existence of such a universal receiver for a prescribed set of channels are established, procedures are outlined for the receiver design, and an example is given to illustrate the applicability of the theory. For M-ary signaling it is shown that, from an information-theoretic viewpoint, the data verification can be achieved at no extra cost by use of the intrinsic side information that is provided by an appropriate coding scheme that also provides error correction     

Bayesian generation of dependent erasures for frequency-hopcommunications and fading channels

The use of block coding and errors-and-erasures decoding can enhance performance in frequency-hop (FH) communication systems, provided that a good scheme is employed to determine which symbols to erase. The problem of making erasure decisions from collections of receiver outputs is investigated in this paper. Methods to determine which received symbols to erase are derived from Bayesian decision theory. Decision rules are developed for a system with M-ary orthogonal signaling, noncoherent demodulation, and frequency-selective fading. One result is a class of Bayesian schemes in which erasure decisions are made independently from symbol to symbol. Within this class is a rule that uses signal amplitude estimates for improved performance. A second result is a Bayesian technique in which erasure decisions are mutually dependent and are made collectively for each codeword. These techniques are analyzed and compared with the performance of receivers that use erasure techniques that require multiple applications of bounded distance decoding. The performance of the Bayesian techniques for dependent erasures are also compared with the performance of receivers that do not permit erasures. It is found that each of the Bayesian techniques offers substantial performance gains over errors-only decoding, and the dependent erasure scheme provides the best performance among the techniques of lower complexity     

Boundary layer drug delivery using a helical catheter

BACKGROUND: A catheter-based approach for local endovascular drug delivery has been developed. The catheter is deployed percutaneously, while the end of the catheter is in the form of a helix that is placed just proximal to the vascular site to be treated. The helices are in contact with the vessel wall. A number of small holes is drilled in the coils of the catheter through which drug is infused, so that the infused drug remains within the blood fluid 'boundary layer' adjacent to the vessel wall. This approach is expected to be highly efficient for administration of antithrombotic and antiproliferative agents that target processes leading to vascular occlusion, heart attacks, and strokes. METHODS: The helical catheter was qualitatively evaluated using optical dye density measurements of Evans blue dye infused using an in vitro steady flow system under a physiologic range of conditions. To further demonstrate the efficiency of the technique, its capacity to inhibit thrombosis was evaluated in a baboon thrombosis model. The catheter was inserted into a femoral arteriovenous shunt (blood flow rate = 100 ml/min) and placed proximal to a segment of highly thrombogenic Dacron vascular graft (4.0 mm i.d.). Integrelin (an inhibitor of platelet glycoprotein IIb/IIIa; doses: 0.25-1.0 microg/min) and hirudin (an antithrombin; doses: 10-100 microg/min) were used to inhibit thrombus formation. RESULTS: Experimental flow visualization studies demonstrated that high concentrations of the infused Evans blue dye were retained near the vessel wall. In the animal experiments, platelet deposition on the Dacron graft surface was reduced by 82-97% (Integrelin) and 68-92% (hirudin) over 1-2 h of blood exposure. The local antithrombotic effects produced were found to be 200-fold and 30-fold more efficient than systemic administration of the same agents. CONCLUSIONS: Local drug infusion using the helical catheter approach can achieve high drug concentration levels at target sites, may avoid systemic effects, and can reduce cost of therapy by reducing total drug requirements.     

Performance of Offset Quadriphase Spread-Spectrum Multiple-Access Communications

New analytical results are obtained on the performance of quadriphase spread-spectrum multiple-access communications. The primary performance parameter considered is the signal-to-noise ratio at the receiver output. This parameter includes the effects of multiple-access interference and channel noise, and it has been shown to give a reliable estimate of the average probability of error.     

New correlation identities for periodic sequences

Identities are established which relate certain crosscorrelation parameters for periodic real-valued sequences to their autocorrelation functions. Applications to multiple-access communication systems and to the design of uncorrelated sequences are discussed.     

Delay and throughput for three transmission schemes in packet radionetworks

The results of a simulation of a fully connect packet communication network are presented. The network employs the slotted ALOHA channel access protocol, and Reed-Solomon coding is used to correct errors and erasures in the received packets. The network has a fixed number of channels available for packet transmissions. In two of the transmission schemes considered, a given packet transmission occurs on a single channel only. One of these employs fixed assignment of terminals to the channels, and the other employs random assignment. A third method permits each transmitter to hop randomly over the set of channels during the transmission of a packet. The terminal transmits on one channel at a time, and it transmits a fixed number of symbols during each dwell interval. Delay and throughput are evaluated for all three transmission methods. The effects of code rate on the performance of the channel-hopping scheme are explored, and the improvement that can be obtained for the channel-hopping scheme by use of incremental-redundancy transmission is examined     

An Adaptive-Transmission Protocol for Frequency-Hop Wireless Communication Networks

An energy-efficient adaptive-transmission protocol for mobile frequency-hop spread-spectrum wireless communication networks is described and evaluated. The purpose of the protocol is to permit each of the mobile terminals to adjust its transmitter power and code rate to match the characteristics of the time-varying communication links in the network. The proposed adaptive-transmission protocol bases its choice of transmission parameters on a very simple form of side information that is easy to obtain in a FH communication receiver. The performance of the adaptive-transmission protocol is evaluated for networks in which each communication link may have a time-varying propagation loss and intermittent partial-band interference. Our results demonstrate that the adaptive-transmission protocol can improve the utility of a link and reduce energy consumption by adjusting the transmission parameters in response to changes in the side information.     

Multimedia multicast wireless communications with phase-shift-keymodulation and convolutional coding

Broadcast or multicast signaling can be employed in a wireless communication network to transmit a message to multiple neighbors simultaneously. The capabilities of the intended recipients may vary in the sense that the communication links to some neighbors may have less interference or attenuation than the links to others. We have previously proposed the use of nonuniform phase-shift key (PSK) signal constellations to allow a transmitter to deliver a basic message to each of the intended receivers and an additional message to the more-capable receivers. In this paper, convolutional coding and nonuniform PSK modulation are combined to provide greater efficiency and increased flexibility. The primary goal of multicast transmission, which is for each designated neighbor to have an acceptable probability of receiving the multicast message correctly, is achieved in a way that permits inclusion of multimedia messages for the more-capable receivers. Performance results and tradeoffs are presented for hard- and soft-decision decoding of convolutionally encoded coherent M-ary PSK multicast transmissions. Our results show that convolutional coding can be used with nonuniform PSK modulation to transmit additional information in mobile communication systems with little degradation to the basic information     

Effects of cloprostenol sodium at final prostaglandin F2α of Ovsynch on complete luteolysis and pregnancy per artificial insemination in lactating dairy cows

Luteolysis is a key event in Ovsynch programs of lactating dairy cows. Studies indicate that as many as 20% of cows treated with a Presynch/Ovsynch program have delayed or incomplete luteolysis using dinoprost tromethamine. Cows must have complete luteolysis to have a chance to become pregnant. Dinoprost tromethamine has a short half-life of approximately 7 to 8 min. Cloprostenol sodium is more resistant to endogenous metabolism and is maintained in circulation for a longer time (half-life = 3 h). The objective was to determine if cloprostenol sodium could increase the percentage of cows with complete luteolysis and subsequent pregnancy per artificial insemination (P/AI) in lactating dairy cows compared with dinoprost tromethamine when administered within a presynchronization plus Ovsynch program for first artificial insemination (n = 652) and an Ovsynch resynchronization program for second or later AI (second+; n = 394). Blood samples were collected daily for 5 d beginning at the PGF_2α of Ovsynch in a subset of cows (n = 680) for first and second+ AI to measure circulating concentrations of progesterone (P₄) and estradiol (E₂). Complete luteolysis was defined as cows with functional corpus luteum (CL) at time of treatment and serum concentrations of P₄ <0.5 ng/mL at 56, 72, and 96 h after treatment. Percentage of cows with functional CL that had complete luteolysis after treatment was not greater for cloprostenol sodium compared with dinoprost tromethamine in first (79 vs. 80%, respectively) or second+ AI (70 vs. 72%, respectively). In addition, mean serum concentrations of P₄ were not less for cows treated with cloprostenol sodium following treatment. Pregnancy per AI of cows treated with cloprostenol sodium tended to be greater than dinoprost tromethamine for first (40 vs. 35%; respectively) but not second+ AI (23 vs. 21%, respectively). Cows with greater serum P₄ concentrations at time of PGF_2α of Ovsynch had a greater probability of undergoing complete luteolysis after PGF_2α of Ovsynch and pregnancy at 39 d after timed AI (i.e., 50% pregnant at 8 vs. 28% pregnant at 4 ng/mL P₄). Serum concentrations of E₂ at 56 h after PGF_2α of Ovsynch were a positive predictor of pregnancy at 39 d after timed AI. In summary, cloprostenol sodium tended to improve P/AI. Cows with greater serum concentrations of P₄ at time of PGF_2α of Ovsynch had a greater chance of luteolysis and pregnancy.     

Energy-Efficient Routing for Frequency-Hop Wireless Networks

The use of adaptive-transmission protocols in wireless, store-and-forward, packet communication networks may result in large differences in the energy requirements of the alternative paths that are available to the routing protocol. Routing metrics can provide quantitative measures of the quality and energy efficiency of the paths from the source to the destination. Such measures are required if the routing protocol is to take advantage of the potential energy savings that are made possible by an adaptive-transmission protocol. An energy-efficient protocol suite for routing and adaptive transmission in frequency-hop wireless networks is described and evaluated, several routing metrics are compared, and tradeoffs among energy efficiency, delay, and packet success probability are investigated.