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排序方式: 共有163条查询结果,搜索用时 15 毫秒
1.
Simonetta Balsamo Vittoria De Nitto Person Paola Inverardi 《Performance Evaluation》2003,51(2-4):269-288
A review is carried out on how queueing network models with blocking have been applied so far into the performance evaluation and prediction of Software Architectures (SA). Queueing network models with finite capacity queues and blocking have recently been introduced and applied as more realistic models of systems with finite capacity resources and population constraints. Queueing network models have been often adopted as models for the evaluation of software performance. Starting from our own experience, we observe the need of a more accurate definition of the performance models of SA to capture some features of the communication systems. We consider queueing networks with finite capacity and blocking after service (BAS) to represent some synchronization constraints that cannot be easily modeled with queueing network models with infinite capacity queues. We investigate the use of queueing networks with blocking as performance models of SA with concurrent components and synchronous communication. Queueing theoretic analysis is used to solve the queueing network model and study the synchronous communication and performance of concurrent software components. Our experience is supported by other approaches that also propose the use of queueing networks with blocking. Directions for future research work in the field are included. 相似文献
2.
Ferrari A. Ghislotti G. Balsamo S. Spano V. Trezzi F. 《Lightwave Technology, Journal of》2002,20(3):515-518
The behavior of fiber Bragg grating (FBG)-stabilized 980-nm pump lasers is experimentally and theoretically investigated. The subkilohertz noise in the emitted power is related to the coexistence and oscillation between coherence collapsed state and narrow linewidth single-mode (SM) operation. These findings are theoretically discussed by using a multimode time-domain model that accounts for spatial harmonics and includes nonlinear gain. One additional result is an indication that kinks in the L-I curve can be explained by nonlinear mode competition 相似文献
3.
4.
Simonetta Pazzaglia Barbara Tanno Francesca Antonelli Paola Giardullo Gabriele Babini Prabal Subedi Omid Azimzadeh Zohaib N. Khan Kateryna Oleksenko Fabian Metzger Christine von Toerne Damien Traynor Dinesh Medipally Aidan D. Meade Munira Kadhim Fiona M. Lyng Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2021,22(8)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health. 相似文献
5.
Oliaro-Bosso S Schulz-Gasch T Balliano G Viola F 《Chembiochem : a European journal of chemical biology》2005,6(12):2221-2228
A structural model of Saccharomyces cerevisiae oxidosqualene cyclase (SceOSC) suggests that some residues of the conserved sequence Pro-Ala-Glu-Val-Phe-Gly (residues 524-529) belong to a channel constriction that gives access to the active-site cavity. Starting from the SceOSC C457D mutant, which lacks the cysteine residue next to the catalytic Asp456 residue Cys457 has been replaced but Asp456 is still there, we prepared two further mutants where the wild-type residues Ala525 and Glu526 were individually replaced by cysteine. These mutants, especially E526C, were very sensitive to the thiol-reacting agent dodecyl-maleimide. Moreover, both the specific activity and the thermal stability of E526C were severely reduced. A similar decrease of the enzyme functionality was obtained by replacing Glu526 with alanine, while substitution with the conservative residues aspartate or glutamine did not alter catalytic activity. Molecular modeling of the yeast wild-type OSC and mutants on the template structure of human OSC confirms that the channel constriction is an important aspect of the protein structure and suggests a critical structural role for Glu526. 相似文献
6.
Stefano Federici Simonetta Montemagni Vito Pirrelli 《Computers and the Humanities》2000,34(1-2):199-204
The paper describes SENSE, a word sense disambiguation system thatmakes use of different types of cues to infer the most likelysense of a word given its context. Architecture and functioning ofthe system are briefly illustrated. Results are given for theROMANSEVAL Italian test corpus of verbs. 相似文献
7.
Dagens B. Balsamo S. Montrosset I. 《IEEE journal of selected topics in quantum electronics》1997,3(2):233-244
Amplification of ultrashort pulses in a semiconductor flared amplifier is analyzed by using a two dimensional (2-D) time-domain BPM (beam propagation method) model including the effects of gain saturation, finite-gain bandwidth, self-phase modulation, index dispersion, carrier heating, and gain relaxation between successive pulses induced by carrier diffusion and recombination. The paper includes a presentation of the model and of the numerical resolution method, detailed analysis and discussion of the spatio-temporal pulse distortions in the case of picosecond and subpicosecond pulses and an evaluation of the device performance. The performance of the flared amplifier is evaluated considering the temporal length, the time-bandwidth product, the far field, the output energy as a function of the input energy, the injected current, and the repetition rate. While subpicosecond pulse amplification leads to strong distortions and to very low total gain, the flared amplifier is well adapted to the amplification of picosecond pulses at low-repetition rates 相似文献
8.
Francesco Merola Simonetta Grilli Sara Coppola Veronica Vespini Sergio De Nicola Pasquale Maddalena Cosimo Carfagna Pietro Ferraro 《Advanced functional materials》2012,22(15):3267-3272
Investigation on the behavior of nematic liquid crystals on functionalized polar dielectric crystal substrates is accomplished. Very interesting effects can be observed in maneuvering liquid crystal droplets on the substrate surface, driven by electric fields generated by pyroelectric effect. Reversible drops fragmentation and self‐assembling in different configurations can be achieved. The dynamics of the observed phenomena is studied and the repeatability of the process is full assessed. 相似文献
9.
Simonetta Caira Gabriella Pinto Valentin A. Balteanu Lina Chianese Francesco Addeo 《Food chemistry》2013
A novel genetic variant at the αs1-casein locus of water buffalo (WB), 8-residue shorter than its wild-type has been found and sequenced. The internal deletion of the peptide E35KVNELsT42 was confirmed by the isolation of the junction peptide. The 8-residue deletion mutant has a molecular weight that is 919 Da less than that of the wild-type. The novel isoform with a unique f35-42 deletion could be the result of the skipping of exon 6, generating an exon 6-deleted variant of αs1-casein. The wild-type and its shortened αs1-casein forms were found to co-exist in many individual milk samples. In contrast, the 8-residue, internally deleted αs1-casein variant did not occur in water buffaloes of the Mediterranean breed reared in Italy. Wild-type αs1-casein has 6 to 8 phosphate groups (P) while the internally deleted form 6 and 7P per molecule. 相似文献