Controlling for stimulus dominance in dichotic listening tests: A modification of !l.

Dichotic listening procedures have been used to assess cerebral lateralization in normal Ss. One particularly useful technique is the use of stimuli that fuse into a single percept. Although this procedure has many advantages over other dichotic listening methods, it is particularly susceptible to stimulus dominance, which acts as noise in a S's response data, thus reducing the power of any statistical test of the ear advantage. It is proposed that the solution to this problem is a log-linear analysis of the response data to yield a λ-type index (λ*) that is a measure of ear dominance independent of stimulus dominance. Details of the analysis are provided, as well as a sample analysis of data collected from 104 right-handed and 30 left-handed Ss. Comparisons are drawn between the log-linear analysis and other methods that have been proposed to control for stimulus dominance in this single-response dichotic fusion procedure. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Tweet this: A uses and gratifications perspective on how active Twitter use gratifies a need to connect with others

Twitter is an Internet social-network and micro-blogging platform with both mass and interpersonal communication features for sharing 140-character messages, called tweets, with other people, called followers. Hierarchical OLS regression of survey results from 317 Twitter users found that the more months a person is active on Twitter and the more hours per week the person spends on Twitter, the more the person gratifies a need for an informal sense of camaraderie, called connection, with other users. Controlling for demographic variables does not diminish this positive relationship. Additionally, frequency of tweeting and number of @replies, public messages between Twitter users, mediate the relationship between active Twitter use and gratifying a need for connection. Results are discussed in light of uses and gratifications theory.     

Reach and posture hand preferences during arboreal feeding in sifakas (Propithecus sp.): A test of the postural origins theory of behavioral lateralization.

Sixteen sifakas (11 Propithecus verreauxi coquereli, 2 Propithecus verreauxi verreauxi form majori, and 3 Propithecus tattersalli) were videotaped as they fed on leaves in an arboreal context. The hand used to feed and the hand used to maintain postural stability was coded. For each subject, the lateral bias of the hand used to feed was opposite the hand used in postural support. Seven sifakas displayed no bias for feeding or posture-related hand use, 7 sifakas displayed significant feeding-related reach preferences for pulling branches to the mouth (5 left- and 2 right-hand preferences), and 9 sifakas exhibited significant hand preferences for postural support (2 left-, 7 right-hand preferent). Although these data do not strongly support the postural origins theory of behavioral lateralization, the modal preference pattern for sifakas that displayed significant hand preferences for posture and feeding involve a left bias for feeding and a right bias for postural support. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Accountability in Child Welfare Services: Developing a Statewide Outcome Evaluation Program.

Questions are often raised regarding the effectiveness and value of treatment programs for children and families. Recently, programs have been increasingly held accountable for services offered. In response, the member agencies of IARCCA have developed a comprehensive outcome measurement program. This article describes the project, focusing on the conditions that led to its inception and how the measurement plan was developed. In addition, the article includes information on the selection of personnel, measurement instruments, and methods and on the process of data collection. Summary results are provided, including how these results are utilized to improve services. Finally, the continued expansion and future directions of the Outcome Project are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

EMDR Therapy Following the 9/11 Terrorist Attacks: A Community-Based Intervention Project in New York City.

This article presents the results of a time-limited psychological relief effort using eye movement desensitization and reprocessing (EMDR) following the attacks on the World Trade Center on September 11, 2001. Clients made highly significant positive gains on a range of outcome variables, including validated psychometrics and self-report scales. Analyses of the data suggest 2 broad conclusions: EMDR is a useful treatment intervention both in the immediate aftermath of disaster as well as later; the longer treatment is delayed, the greater the level of disturbance experienced by clients. Also discussed are problems in conducting research during mass disaster response situations. A demonstration of an analog to a wait-list control group is provided. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization

Tropomyosin receptor kinase A (TrkA/NTRK1) is a high-affinity receptor for nerve growth factor (NGF), a potent pain mediator. NGF/TrkA signaling elevates synovial sensory neuronal distributions in the joints and causes osteoarthritis (OA) pain. We investigated the mechanisms of pain transmission as to whether peripheral sensory neurons are linked to the cellular plasticity in the dorsal root ganglia (DRG) and are critical for OA hyperalgesia. Sensory neuron-specific deletion of TrkA was achieved by tamoxifen injection in 4-week-old TrkA^fl/fl;Na_V1.8^CreERT2 (Ntrk1 ^fl/fl;Scn10a^CreERT2) mice. OA was induced by partial medial meniscectomy (PMM) in 12-week-old mice, and OA-pain-related behavior was analyzed for 12 weeks followed by comprehensive histopathological examinations. OA-associated joint pain was markedly improved without cartilage protection in sensory-neuron-specific conditional TrkA knock-out (cKO) mice. Alleviated hyperalgesia was associated with suppression of the NGF/TrkA pathway and reduced angiogenesis in fibroblast-like synovial cells. Elevated pain transmitters in the DRG of OA-induced mice were significantly diminished in sensory-neuron-specific TrkA cKO and global TrkA cKO mice. Spinal glial activity and brain-derived neurotropic factor (BDNF) were significantly increased in OA-induced mice but were substantially eliminated by sensory-neuron-specific deletion. Our results suggest that augmentation of NGF/TrkA signaling in the joint synovium and the peripheral sensory neurons facilitate pro-nociception and centralized pain sensitization.     

Disease Recurrence during Adjuvant Immune Checkpoint Inhibitor Treatment in Metastatic Melanoma: Clinical,Laboratory, and Radiological Characteristics in Patients from a Single Tertiary Referral Center

Despite the dramatic improvements in recurrence-free survival in patients with metastatic melanoma treated with immune checkpoint inhibitors (ICI), a number of patients develop metastases during adjuvant therapy. It is not currently possible to predict which patients are most likely to develop disease recurrence due to a lack of reliable biomarkers. Thus, we retrospectively analyzed the case records of all patients who commenced adjuvant ICI therapy between January 2018 and December 2021 in a single university skin cancer center (n = 46) (i) to determine the rates of disease recurrence, (ii) to examine the utility of established markers, and (iii) to examine whether re-challenge with immunotherapy resulted in clinical response. Twelve out of forty-six (26%) patients developed a relapse on adjuvant immunotherapy in our cohort, and the median time to relapse was 139 days. Adjuvant immunotherapy was continued in three patients. Of the twelve patients who developed recurrence during adjuvant immunotherapy, seven had further disease recurrence within the observation period, with a median time of 112 days after the first progress. There was no significant difference comparing early recurrence (<180 days after initiation) on adjuvant immunotherapy to late recurrence (>180 days after initiation) on adjuvant immunotherapy. Classical tumor markers, including serum lactate dehydrogenase (LDH) and S-100, were unreliable for the detection of disease recurrence. Baseline lymphocyte and eosinophil counts and those during immunotherapy were not associated with disease recurrence. Interestingly, patients with NRAS mutations were disproportionately represented (60%) in the patients who developed disease recurrence, suggesting that these patients should be closely monitored during adjuvant therapy.     

Highly Charged Ru(II) Polypyridyl Complexes as Photosensitizer Agents in Photodynamic Therapy of Epithelial Ovarian Cancer Cells

Ovarian cancer recurrence is frequent and associated with chemoresistance, leading to extremely poor prognosis. Herein, we explored the potential anti-cancer effect of a series of highly charged Ru(II)-polypyridyl complexes as photosensitizers in photodynamic therapy (PDT), which were able to efficiently sensitize the formation of singlet oxygen upon irradiation (Ru1²⁺ and Ru2²⁺) and to produce reactive oxygen species (ROS) in their corresponding dinuclear metal complexes with the Fenton active Cu(II) ion/s ([CuRu1]⁴⁺ and [Cu₂Ru2]⁶⁺). Their cytotoxic and anti-tumor effects were evaluated on human ovarian cancer A2780 cells both in the absence or presence of photoirradiation, respectively. All the compounds tested were well tolerated under dark conditions, whereas they switched to exert anti-tumor activity following photoirradiation. The specific effect was mediated by the onset of programed cell death, but only in the case of Ru1²⁺ and Ru2²⁺ was preceded by the loss of mitochondrial membrane potential soon after photoactivation and ROS production, thus supporting the occurrence of apoptosis via type II photochemical reactions. Thus, Ru(II)-polypyridyl-based photosensitizers represent challenging tools to be further investigated in the identification of new therapeutic approaches to overcome the innate chemoresistance to platinum derivatives of some ovarian epithelial cancers and to find innovative drugs for recurrent ovarian cancer.     

Comparison of bioactive phytochemical content and release of isothiocyanates in selected brassica sprouts

The consumption of brassica sprouts as raw vegetables provides a fair amount of glucosinolates (GLs) and active plant myrosinase, which enables the breakdown of GLs into health-promoting isothiocyanates (ITCs). This study reports the determination of the main constituents related to human health found in edible sprouts of two Brassica oleracea varieties, broccoli and Tuscan black kale, and two Raphanus sativus varieties, Daikon and Sango. Radish sprouts exhibited the highest ability to produce ITCs, with Daikon showing the greatest level of conversion of GLs into bioactive ITCs (96.5%), followed by Sango (90.0%). Tuscan black kale gave a value of 68.5%, whereas broccoli displayed the lowest with 18.7%. ITCs were not the exclusive GL breakdown products in the two B. oleracea varieties, since nitriles were also produced, thus accounting for the lower conversion observed. Measuring the release of plant ITCs is a valuable tool in predicting the potential level of exposure to these bioactive compounds after the consumption of raw brassica sprouts.     

Generativity and spiritual disclosure in close relationships.

This exploratory study examines the link between generativity and an interpersonal aspect of religion and spirituality, spiritual disclosure, in close relationships. Three hundred seventy-eight adults aged 18 to 85 years were asked about their use of spiritual disclosure with close friends, views on their own generativity, questions related to personality characteristics, and level of general self-disclosure. This community sample’s reports on higher levels of spiritual disclosure were tied to higher levels of generativity and general self-disclosure. Spiritual disclosure also predicted unique variance in generativity beyond general self-disclosure, personality, and intrapersonal aspects of religion and spirituality. These findings suggest spiritual disclosure in close relationships is an important part of the religious/spiritual landscape, which merits further study in relation to generativity and other prosocial indices. (PsycINFO Database Record (c) 2010 APA, all rights reserved)