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排序方式: 共有647条查询结果,搜索用时 171 毫秒
1.
Akira Minami Yuuki Kurebayashi Tadanobu Takahashi Tadamune Otsubo Kiyoshi Ikeda Takashi Suzuki 《International journal of molecular sciences》2021,22(6)
Sialidase cleaves sialic acid residues from glycans such as glycoproteins and glycolipids. In the brain, desorption of the sialic acid by sialidase is essential for synaptic plasticity, learning and memory and synaptic transmission. BTP3-Neu5Ac has been developed for sensitive imaging of sialidase enzyme activity in mammalian tissues. Sialidase activity in the rat hippocampus detected with BTP3-Neu5Ac increases rapidly by neuronal depolarization. It is presumed that an increased sialidase activity in conjunction with neural excitation is involved in the formation of the neural circuit for memory. Since sialidase inhibits the exocytosis of the excitatory neurotransmitter glutamate, the increased sialidase activity by neural excitation might play a role in the negative feedback mechanism against the glutamate release. Mammalian tissues other than the brain have also been stained with BTP3-Neu5Ac. On the basis of information on the sialidase activity imaging in the pancreas, it was found that sialidase inhibitor can be used as an anti-diabetic drug that can avoid hypoglycemia, a serious side effect of insulin secretagogues. In this review, we discuss the role of sialidase in the brain as well as in the pancreas and skin, as revealed by using a sialidase activity imaging probe. We also present the detection of influenza virus with BTP3-Neu5Ac and modification of BTP3-Neu5Ac. 相似文献
2.
Michio Kumagai Kanako Ishikawa Jiao Chunmeng 《Lakes & Reservoirs: Research and Management》2002,7(4):345-348
We have examined two aspects of the dynamics and biogeochemical significance of the physical environment in Lake Biwa. One is the horizontal distribution of cyanobacteria as it relates to the ‘first gyre’ in the north basin of Lake Biwa. We could easily measure the first gyre using a vessel‐mounted acoustic doppler currents profiler. We were able to quantify the dynamics of the horizontal and vertical structure of currents and water temperature of this gyre. The first gyre did not remain at a fixed position; it moved north and south according to the growth of the gyre. This may play a role in the redistribution of cyanobacteria from place to place in the north basin. The second important environmental dynamic we measured was oxygen consumption rates from 1994 to 2000. We found that the minimum oxygen concentration in the hypolimnion has a clear inverse relationship with the apparent oxygen consumption rates in the 80–85 m depth layer. As a reduction in oxygen concentration in the hypolimnion can have a serious impact on benthic organisms, we concluded that the Lake Biwa environment should be monitored carefully and systematically. 相似文献
3.
Inertinite concentrates from three Australian bituminous coals were hydrogenated at various temperatures ranging from 350 to 475 °C in the presence of tetralin without any added catalyst. Both conversion yields and microscopic observations of the benzene-extracted hydrogenation residues have revealed that the hydrogenation of the inertinite macerals becomes significant only > 400 °C, whereas the dissolution-hydrogenation of the accompanying vitrinite macerals occurs mainly between 350 and 400 °C. The major reaction pathway for the inertinite particles in the hydrogenation process appears to be one of initial mild carbonization followed by hydrogenation. A simplified reaction scheme is proposed which describes the reaction pathway involved in the hydrogenation of inertinite. 相似文献
4.
膨胀石墨对各种油类的吸附动力学 总被引:9,自引:1,他引:8
Michio INAGAKI Tomoya NAGATA Taisuke SUWA Masahiro TOYODA 《新型炭材料》2006,21(2):97-102
通过对吸附率(有效吸附系数)Ks和饱和吸附量msat的测量,描述了粘度为0.001 Pa·s~0.850 Pa·s的各种油类在膨胀石墨柱中的吸附动力学,发现吸附率Ks对油类粘度有很强的相关性.吸入膨胀石墨柱中的饱和吸附量msat几乎恒定在50kg/kg,该值略低于由膨胀石墨块直接浸渍在油中测得的吸附容量,这是由于所吸附的油沿膨胀石墨柱高度存在重力梯度. 相似文献
5.
Tsuyoshi Takahashi Masahito Kitou Michio Asai Mitsuyasu Kido Tomio Chiba Junzou Kawakami Yoshiaki Matsui 《Electrical Engineering in Japan》1994,114(2):18-33
Power system control equipment needs higher sensitivity and operational reliability. Advanced voltage control equipment is needed for reducing the frequency of tap changes and improving the characteristics (the relationship between the actual voltage and reference voltage) of the voltage to meet today's power system requirements. However, these objectives are in a trade-off relationship. Studies of voltage control derived from a knowledge base suitable for electric power systems can satisfy these objectives using fuzzy inference. Compared with corresponding conventional equipment, the new equipment improved the deviation of 30 min average voltage of 30 percent. This paper describes the design concept of new voltage control equipment using fuzzy inference. In addition, field test results are described along with rules of fuzzy inference, membership functions, and the deviation of 30 min average voltage through detailed simulation. 相似文献
6.
Design of active vehicle suspension has tradeoffs between three main performance metrics (passenger comfort, suspension deflection
and road holding ability). It has been known that each performance can be achieved by H
∞ controller and they can be gathered by LPV (Linear Parameter Varying) method. However, because the suspension deflection
limit was not explicitly considered, this limit may be exceeded. In this paper, the authors propose a “reference shaping“
based method in order to improve the control performance. In this approach, a “virtual reference” signal is imposed to the
system such that the suspension deflection is kept small. The effectiveness of the approach is examined by numerical simulations.
This work was presented in part at the 13th International Symposium on Artificial Life and Robotics, Oita, Japan, January
31–February 2, 2008 相似文献
7.
In this article, a new control scheme named repetitive control is proposed for a class of nonlinear systems described by x(t) = Ax(t) + Bu(t) + n(x(t)) and y(t) = Cx(t), in which the controlled variables follow periodic reference commands. The stability condition is derived by applying the passivity theorem. We show how to apply the repetitive control scheme to the trajectory control of a manipulator. A simple repetitive control scheme is developed for the trajectory control of a manipulator by using nonlinear compensation and feedbacks of position and velocity signals. Experimental results for a three link manipulator verify that the proposed repetitive control reduces the tracking error to a very low level. 相似文献
8.
Yoshiro Nakamura Akira Watanabe Kunio Mori Kosaku Tamura Michio Inagaki 《Journal of Materials Science》1986,21(12):4485-4488
A binary blend which consists of two incompatible polymers such as poly(vinyl chloride) and polyethylene has been performed through a partial co-crosslinking reaction with peroxide to give a co-crosslinked blend with a uniform dispersion of small polyethylene particles and with an improved mechanical property. The results are obtained through the formation of a co-crosslinked product which acts as a potential solid phase dispersant as well as a well-bonded reinforcing interlayer on polyethylene particles uniformly dispersed in poly(vinyl chloride) matrix. The resulting blends (PVC/PE=10/90 wt) give carbon spherules of 0.5 to 1m diameter through pressure-carbonization at 650° C for 1 h. 相似文献
9.
F. Otsubo K. Kishitake T. Akiyama T. Terasaki 《Journal of Thermal Spray Technology》2003,12(4):555-559
It is known that the corrosion resistance of stainless steel is deteriorated by blasting, but the reason for this deterioration
is not clear. A blasted austenitic stainless steel plate (JIS-SUS304) has been characterized with comparison to the scraped
and non-blasted specimens. The surface roughness of the blasted specimen is larger than that of materials finished with #180
paper. A martensite phase is formed in the surface layer of both blasted and scraped specimens. Compressive residual stress
is generated in the blasted specimen and the maximum residual stress is formed at 50–100 μm from the surface. The corrosion
potentials of the blasted specimen and subsequently solution treated specimen are lower than that of the non-blasted specimen.
The passivation current densities of the blasted specimens are higher those of the non-blasted specimen. The blasted specimen
and the subsequently solution treated specimen exhibit rust in 5% sodium chloride (NaCl) solution, while the non-blasted specimen
and ground specimen do not rust in the solution. It is concluded that the deterioration of corrosion resistance of austenitic
stainless steel through blasting is caused by the roughed morphology of the surface. 相似文献
10.
Characterization of plasma sprayed Fe-17Cr-38Mo-4C amorphous coatings crystallizing at extremely high temperature 总被引:5,自引:0,他引:5
A Fe-17Cr-38Mo-4C alloy powder was plasma sprayed by three processes: an 80 kW low-pressure plasma spray (LPPS), a 250 kW
high-energy plasma spray (HPS), and a 40 kW conventional plasma spray (APS). The as-sprayed coating obtained by the LPPS process
is composed of only amorphous phase. As-sprayed coatings obtained by the HPS and APS processes are a mixture of amorphous
and crystalline phases. The three as-sprayed coatings exhibit a high hardness of 1000 to 1100 DPN. The amorphous phase in
these coatings crystallizes at a high temperature of about 920 K. A very fine structure composed of hard ϰ-phase and carbides
is formed after crystallization. The hardness of the coating obtained by LPPS reaches a maximum of 1450 DPN just after crystallization
on tempering and retains a high hardness more than 1300 DPN after tempering at high temperatures of 1173 or 1273 K. The corrosion
potential of the amorphous coating is the highest among the three coatings and higher than that of a SUS316L stainless steel
coating. The anodic polarization measurements infer that the corrosion resistance of the amorphous coating is superior or
comparable to SUS316L stainless steel coating in H2SO4 solution. 相似文献