The development of a new integral control model based on the analysis of three complex systems in Serbia

The aim of this paper is to analyse the results of research carried out in the railway, mining, and electric power systems in Serbia and form a new integral control model. The three methodological procedures are applied. First, analytical-synthetic methodological approach breaks down complex technical system into three parts: bio-cybernetic system, “operator”; technical system, “technology”; and additional system, “working environment.” Second, network planning method is used to analyse time, according to the critical path method. Third, fuzzy analytic hierarchy process determines the key research factors. General results of research are new integral control model, and new research areas and activities. The most prominent factors are: in “bio-cybernetic system”—operator’s arm reach, body postures and movement sequences, operator’s work, occurrence of stress, and occurrence of fatigue; in “technical system”—location and dimension of control desk, display panel, video display terminal, symbols on video display terminal, colours in control centres, and suitability of the keyboards; and in “supporting system”—illumination in control centres and relative humidity. Based on the analysis of factors and synthesis of results, the following recommendation are proposed: new control desk design; new display panel design; new design of the main and local lighting; new illumination and contrast characteristics, and environmental impact assessment. For research on a variety of complex technical systems, new integral control model can be applied, with corresponding extensions.     

Role of serotonin in obsessive-compulsive disorder

BACKGROUND: Serotonin may play a role in the pathophysiology of obsessive-compulsive disorder (OCD) because of the anti-obsessional effect of selective serotonin reuptake inhibitors (SSRIs). METHOD: The literature is reviewed on knowledge of the role of serotonergic neurons in brain function, studies on monoamine metabolites in cerebrospinal fluid (CSF), various stress neuropeptides, neuroendocrine and behavioural challenge after administration of direct and indirect serotomimetic compounds, and neuroanatomical data on brain circuits organising behaviour. RESULTS: In most of the OCD cases analysed, CSF 5-hydroxyindoleacetic acid and homovanillic acid concentrations do not significantly differ from age-corrected controls. However, a relationship appears to exist between pre-treatment levels of these metabolites and clinical response to drugs acting on the serotonin transporter. Abnormalities in CSF arginine vasopressin, corticotropin-releasing hormone, oxytocin and somatostatin levels have been reported in OCD. Long-term treatment with high-doses of clomipramine, fluvoxamine, and fluoxetine tend to correct these neuropeptide abnormalities. CONCLUSIONS: We hypothesise that continuous treatment with SSRIs alters serotonin turnover and neuropeptide expression patterns in OCD-entertaining functional forebrain/midbrain circuits.     

Expression of Leu-19 (CD56, N-CAM) and nitric oxide synthase (NOS) I in denervated and reinnervated human skeletal muscle.

Neural cell adhesion molecule (N-CAM, Leu-19, CD 56) expression appears during muscle fiber regeneration and after denervation. Sarcolemma-associated nitric oxide synthase (NOS) I, however, disappears from denervated myofibers. The dynamics of expression of both proteins were studied in 5 cases of acute/subacute denervation, 28 cases of chronic denervation with and without collateral reinnervation, 5 cases of the intermediate type spinal muscular atrophy (SMA 2), and in 2 normal biopsies. NOS I and its NADPH diaphorase (NADPHd) activity disappeared from the sarcolemma region shortly after denervation, and before the appearance of denervation atrophy. N-CAM was found diffusely distributed in the sarcoplasm at the most severe phase of denervation atrophy in the majority of highly atrophic fibers. During reinnervation, NOS I expression remained absent and in part of the cases the target/targetoid phenomenon appeared. In parallel with the increase in volume of the reinnervated muscle fibers, the intensity of N-CAM immunoreactivity decreased progressively. After full restitution of muscle fiber caliber, the target/targetoid phenomenon and N-CAM immunostaining disappeared completely, and, finally, NOS I reappeared in the sarcolemma region. The sarcolemmal expression of dystrophin and dystrophin-associated proteins was unchanged during denervation. NOS I was completely absent in children with SMA 2, since the protein does not appear before 5 years of age in skeletal muscle, while N-CAM was very intensely expressed in the sarcoplasm of highly atrophic denervated muscle fibers. In conclusion, this study suggests that innervation is an important factor for selective gene expression and positioning of NOS I and N-CAM in skeletal muscle and gives practical information for the assessment of the phase and developmental stage of the denervation and reinnervation process.     

Interaction between an operator and the control desk at the control room of the railway traffic: A Serbian experience

The subject of this paper is the interaction between an operator and the control desk at the Railway Traffic Control Room (RTCR) in Nis, Serbia. The following methods were used for this research: operators' anthropometric measurement; determining of maximum force of the movements of operators' arms; an analysis of workload of the movements of operators' arms, heads and torsos, and an analysis of errors in operators' movements in response to visual cues. The paper presents the following results: static parameter of 20 anthropometric measures of 41 operators' bodies were measured; nine corresponding dimensions of particular body parts for 5th, 50th, and 95th percentile were calculated; 10 characteristic work angles were measured; five corresponding functional body parts were calculated; times and distances covered by operators' arms were measured; maximum forces used for these movements were calculated; positions and number of movements of arms, heads, and torsos of operators were determined, and movement errors and probability of movement errors in choice of direction, arms and cumulative conditional probability were calculated. The research was conducted with the aim of discovering determining factors of mutual synchronization of the operator and desk.     

NO message from muscle.

The synthesis of the free radical gas nitric oxide (NO) is catalyzed by the enzyme NO synthase (NOS). NOS converts arginine and molecular oxygen to NO and citrulline in a reaction that requires NADPH, FAD, FMN, and tetrahydrobiopterin as cofactors. Three types of NOS have been identified by molecular cloning. The activity of the constitutively expressed neuronal NOS (nNOS) and endothelial NOS (eNOS) is Ca(2+)/calmodulin-dependent, whereas that the inducible NOS (iNOS) is Ca(2+)-insensitive. The predominant NOS isoform in skeletal muscle is nNOS. It is present at the sarcolemma of both extra- and intrafusal muscle fibers. An accentuated accumulation of nNOS is found in the endplate area. This strict sarcolemmal localization of nNOS is due its association with the dystrophin-glycoprotein complex, which is mediated by the syntrophins. The activity of nNOS in skeletal muscle is regulated by developmental, myogenic, and neurogenic influences. NO exerts several distinct effects on various aspects of skeletal muscle function, such as excitation-contraction coupling, mitochondrial energy production, glucose metabolism, and autoregulation of blood flow. Inside the striated muscle fibers, NO interacts directly with several classes of proteins, such as soluble guanylate cyclase, ryanodine receptor, sarcoplasmic reticulum Ca(2+)-ATPase, glyceraldehyde-3-phosphate dehydrogenase, and mitochondrial respiratory chain complexes, as well as radical oxygen species. In addition, NO produced and released by contracting muscle fibers diffuses to nearby arterioles where it acts to inhibit reflex sympathetic vasoconstriction.     

A Note on the Ohya-Masuda Quantum Algorithm

We analyze the Ohya-Masuda quantum algorithm that solves the so-called satisfiability problem, which is an NP-complete problem of the complexity theory. We distinguish three steps in the algorithm, and analyze the second step, in which a coherent superposition of states (a pure state) transforms into an incoherent mixture presented by a density matrix. We show that, if nonideal (in analogy with nonideal quantum measurement), this transformation can make the algorithm to fail in some cases. On this basis we give some general notions on the physical implementation of the Ohya-Masuda algorithm.     

The influence of genotypic variation in protein composition on emulsifying properties of soy proteins

This study describes the relationship between the emulsifying properties of soybean proteins and their composition, i.e., glycinin (11S) and β-conglycinin (7S). Twelve investigated soybean genotypes showed significant differences in storage protein composition. The β-conglycinin concentration positively correlated with extractable soluble protein content, which was positively correlated with protein extractability. These data suggest that the level of β-conglycinin has a positive influence on protein extractability. The emulsion activity index (EAI) was strongly and positively correlated with the 11S∶7S ratio and strongly and negatively correlated with the concentration of β-conglycinin. The emulsion stability index (ESI) showed a moderate positive correlation with the monomeric form of glycinin and a strong positive correlation with the ratio of the monomeric to dimeric form of glycinin. No association was evident between ESI and EAI. Also, no relationship was found between ESI or EAI and extractability. Based on these data, it appears that the 11S∶7S ratio strongly reflects the ability of soybean proteins to form emulsions, whereas the ratio of the two different forms of glycinin may be crucial factors for the stability of soybean protein emulsions. Thus, understanding the relationship between protein composition and functionality could be useful for further improvement of functional behavior of soy proteins in food systems.     

Development and Application of a Decision Support System for Human Reliability Assessment – A Case Study of an Electric Power Company

This paper describes the human reliability assessment using absolute probability judgment (APJ) method in the Electric Power Company of Serbia (EPS). Taking into account conventional APJ approach, a new decision support tool EPS‐APJ was developed. The EPS‐APJ tool is intended for use by a group of experts for human error probability assessment. The basic goal of the tool is to facilitate the process of decision‐making by experts, in the complex environment of the electric power companies. The usefulness of this new tool is approved in a case study of use of the EPS‐APJ for the purpose of the analysis of a repair intervention on a 10/0.4‐kV steel lattice tower ‘Nogaje’, in the EPS. For the purpose of this study, a database on work‐related injuries, accidents, and critical interventions occurred over a 10‐year period was created. The research comprised analysis of 1074 workplaces, with the total of 3997 employees. The case study performed at the EPS has confirmed that the EPS‐APJ tool for quantification of human errors is highly applicable, comprehensive, and simple to use. Comparison of the results obtained by application of the EPS‐APJ tool versus the basic APJ method has confirmed the accuracy of the decision support tool, and significant speed advantage in conducting an expert evaluation. Copyright © 2015 John Wiley & Sons, Ltd.     

An improved non-adiabatic FEM model of a line-to-earth fault in buried power cables

It is shown in this paper that the non-adiabatic nature of phase-to-earth fault thermodynamics in buried power cables can be modelled in an even more precise manner by using the FEM. The nonlinear FEM model has been created on the basis of an authentic case of fault caused by a previous mechanical damage of the cable sheath and insulation, as well as heat sources, thermo-physical and electrical material properties as functions of temperature and time. The proposed model is applicable to power cables of all voltage levels with different polymer insulations laid in soils with changeable moisture content, as well as to the dry arc tracking or wet arc tracking phenomena in PVC-insulated cables.