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Ze-Yang Ding Guan-Nan Jin Wei Wang Yi-Min Sun Wei-Xun Chen Lin Chen Hui-Fang Liang Pran K. Datta Ming-Zhi Zhang Bixiang Zhang Xiao-Ping Chen 《International journal of molecular sciences》2016,17(3)
Liver progenitor cells (LPCs) are activated in chronic liver damage and may contribute to liver fibrosis. Our previous investigation reported that LPCs produced connective tissue growth factor (CTGF/CCN2), an inducer of liver fibrosis, yet the regulatory mechanism of the production of CTGF/CCN2 in LPCs remains elusive. In this study, we report that Activin A is an inducer of CTGF/CCN2 in LPCs. Here we show that expression of both Activin A and CTGF/CCN2 were upregulated in the cirrhotic liver, and the expression of Activin A positively correlates with that of CTGF/CCN2 in liver tissues. We go on to show that Activin A induced de novo synthesis of CTGF/CCN2 in LPC cell lines LE/6 and WB-F344. Furthermore, Activin A contributed to autonomous production of CTGF/CCN2 in liver progenitor cells (LPCs) via activation of the Smad signaling pathway. Smad2, 3 and 4 were all required for this induction. Collectively, these results provide evidence for the fibrotic role of LPCs in the liver and suggest that the Activin A-Smad-CTGF/CCN2 signaling in LPCs may be a therapeutic target of liver fibrosis. 相似文献
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Steel-fiber-reinforced polymer (FRP) composite bars (SFCBs) are a novel reinforcement for concrete structures. Because of the FRP’s linear elastic characteristic and high ultimate strength, they can achieve a stable postyield stiffness even after the inner steel bar has yielded, which subsequently enables a performance-based seismic design to easily be implemented. In this study, lateral cyclic loading tests of concrete columns reinforced either by SFCBs or by ordinary steel bars were conducted with axial compression ratios of 0.12. The main variable parameters were the FRP type (basalt or carbon FRP) and the steel/FRP ratio of the SFCBs. The test results showed the following: (1)?compared with ordinary RC columns, SFCB-reinforced concrete columns had a stable postyield stiffness after the SFCB’s inner steel bar yielded; (2)?because of the postyield stiffness of the SFCB, the SFCB-reinforced concrete columns exhibited less column-base curvature demand than ordinary RC columns for a given column cap lateral deformation. Thus, reduced unloading residual deformation (i.e., higher postearthquake reparability) of SFCB columns could be achieved; (3)?the outer FRP type of SFCB had a direct influence on the performance of SFCB-reinforced concrete columns, and concrete columns reinforced with steel-basalt FRP (BFRP) composite bars exhibited better ductility (i.e., a longer effective length of postyield stiffness) and a smaller unloading residual deformation under the same unloading displacement when compared with steel-carbon FRP (CFRP) composite bar columns; (4)?the degradation of the unloading stiffness by an ordinary RC column based on the Takeda (TK) model was only suitable at a certain lateral displacement. In evaluating the reparability of important structures at the small plastic deformation stage, the TK model estimated a much smaller residual displacement, which is unsafe for important structures. 相似文献
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Sun Jing-Jing Lei Cai-Xia Li Ze-Yang Jian Min-Kun Lian Ji-Qiong Ma Li-Li Du Wei-Hao 《Journal of Materials Science: Materials in Electronics》2021,32(19):23798-23810
Journal of Materials Science: Materials in Electronics - TiO2 has been considered as a promising anode material for lithium-ion batteries (LIBs) due to its low cost and high stability, but its low... 相似文献
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利用POM02太阳光度计测得的数据反演得到气溶胶光学厚度和波长指数,选择晴好天气下德令哈和合肥地区的大气气溶胶光学厚度和波长指数数据进行统计分析。得到两地气溶胶光学厚度与波长的季节变化关系,并对气溶胶光学厚度的月变化特征进行分析,得到了两地波长指数、浑浊度系数、气溶胶光学厚度等参数的变化特征,这对研究两地气溶胶光学特性有一定的参考意义。 相似文献
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目前对高倍聚光系统下砷化镓电池性能的实验研究主要是基于室内模拟光源条件下进行的,对室外条件下的研究相对较少.设计并搭建了一小型菲涅尔聚光光伏系统,介绍了系统结构及其工作原理,并对其进行了室外实验研究.实验结果表明:当菲涅尔聚光光伏系统几何聚光比为500,13:00太阳辐射强度达到峰值948 W/m2时,聚光后单片电池的短路电流放大253倍,开路电压增加了0.34 V,电池背板温度为86.6 ℃,短路电流此时达到峰值,开路电压由于芯片温度升高影响并未达到峰值,峰值出现在10:30时,峰值为2.85 V,比太阳辐射强度达到峰值时的开路电压增加了0.03 V,此时电池背板温度为74.4 ℃. 相似文献
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实验研究了以3-巯基丙酸为配体合成的水溶性CdTe量子点经过非偏振光与圆偏振光照射处理后, 量子点的再生长变化规律。采用光致发光谱、紫外-可见吸收光谱、透射电子显微镜与X射线衍射等表征手段分析表明: 非偏振光会促进CdTe量子点的光氧化, 导致量子点尺寸缩小, 荧光发光峰位蓝移, 且发光效率降低; 而圆偏振光增强了配体的光氧化, 在量子点表面形成CdS层, 导致量子点尺寸进一步增大, 荧光发光峰红移, 且发光效率提升。进一步讨论了CdTe量子点与配体之间的键合作用, 相关光化学反应机制及其对量子点光致发光性质的影响。 相似文献
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设计并搭建一套小型聚光太阳电池联合背板温差发电系统,介绍了该系统的结构,推导了该系统输出功率的数学表达式,并在室外对其进行实验研究.结果表明:随着辐射强度的增强,太阳电池短路电流ISC呈近似线性升高,高辐射强度下的增长率比低辐射强度时小;太阳电池的开路电压UOC高于空冷对照组相对应的测量值,日平均高0.16 V,温差发电芯片的最大输出功率出现在辐射强度曲线的下行段,为0.52 W,一天的输出电量为2.9 W·h. 相似文献
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