Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration

Lipoxins (LXs) are autacoids, specialized proresolving lipid mediators (SPMs) acting locally in a paracrine or autocrine fashion. They belong to a complex superfamily of dietary small polyunsaturated fatty acid (PUFA)–metabolites, which direct potent cellular responses to resolve inflammation and restore tissue homeostasis. Together, these SPM activities have been intensely studied in systemic inflammation and acute injury or infection, but less is known about LX signaling and activities in the central nervous system. LXs are derived from arachidonic acid, an omega‐6 PUFA. In addition to well‐established roles in systemic inflammation resolution, they have increasingly become implicated in regulating neuroinflammatory and neurodegenerative processes. In particular, chronic inflammation plays a central role in Alzheimer's disease (AD) etiology, and dysregulated LX production and activities have been reported in a variety of AD rodent models and clinical tissue samples, yet with complex and sometimes conflicting results. In addition, reduced LX production following retinal injury has been reported recently by the authors, and an intriguing direct neuronal activity promoting survival and homeostasis in retinal and cortical neurons is demonstrated. Here, the authors review and clarify this growing literature and suggest new research directions to further elaborate the role of lipoxins in neurodegeneration.     

IGCT 综合型电荷控制 模型的建立和仿真

以电荷控制方程而建立的IGCT综合型电荷控制模型，经关键性的关断电流和关断电压进行了仿真分析，所得结果与实际结果吻合。因此该模型是有效的，可用于IGCT的开关特性分析和集成门极电路设计。     

海南省水资源配置决策的层次分析模型研究

海南省特殊的地理位置决定了其水资源配置问题的独特性,在水资源配置方案中,呈现出多阶段、多层次、多目标、多决策主体的特点,使得水资源配置模型难以确定并给决策带来了很大的风险性。本文研究了适合于海南省水资源优化配置所需的评比指标,对层次分析法加以改进,结合海南省水资源配置问题的决策要求,用改进后的层次分析法进行评价指标优化计算,最终得出了较为满意的结果。     

Abnormalities in plasma and red blood cell fatty acid profiles of patients with colorectal cancer

Intravenous injection of stearoyl vanillylamide (C18-VA), a nonpungent capsaicin (CAP) analog, enhances adrenaline secretion significantly and as effectively as CAP in rats. Because swimming capacity was enhanced by CAP in mice due to CAP-induced adrenal catecholamine secretion, we investigated the effects of oral administration of C18-VA on swimming capacity using an adjustable-current water pool. Male Std ddY 6-wk-old mice were fed a commercial diet for this study and one group was orally administered C18-VA via a stomach tube. Treated mice were able to swim longer before exhaustion than the control mice (62.9 +/- 5.6 vs. 49.6 +/- 7. 0 min, P < 0.05). The swimming capacity of two groups administered C18-VA (0.02 and 0.033 mmol/kg) was significantly greater than that of those administered vehicle alone, (P < 0.05). Substance P concentration in cerebrospinal fluid, which is involved in pain transmission and is the first direct measure of pungency, was not affected by C18-VA administration. In an experiment examining the effects of C18-VA on serum adrenaline concentration, adrenaline was significantly greater in C18-VA treated mice than in controls at 2-h post-dose (C18-VA group, 26.09 +/- 2.82; control group 13.29 +/- 0. 96 microg/L, P < 0.01). In a separate study free fatty acids in serum were elevated in treated mice at 2-h post-dose (P < 0.01). While serum glucose concentration was not affected. These results suggest that C18-VA increased swimming capacity of mice via adrenaline release, independent of pungency. In addition, the present study suggests the usefulness of its application to humans.     

Retrospective adaptive prefetching for interactive Web GIS applications

A major task of a Web GIS (Geographic Information Systems) system is to transfer map data to client applications over the Internet, which may be too costly. To improve this inefficient process, various solutions are available. Caching the responses of the requests on the client side is the most commonly implemented solution. However, this method may not be adequate by itself. Besides caching the responses, predicting the next possible requests from a client and updating the cache with responses for those requests together provide a remarkable performance improvement. This procedure is called “prefetching” and makes caching mechanisms more effective and efficient. This paper proposes an efficient prefetching algorithm called Retrospective Adaptive Prefetch (RAP), which is constructed over a heuristic method that considers the former actions of a given user. The algorithm reduces the user-perceived response time and improves user navigation efficiency. Additionally, it adjusts the cache size automatically, based on the memory size of the client’s machine. RAP is compared with four other prefetching algorithms. The experiments show that RAP provides better performance enhancements than the other methods.     

Uncertainty modeling and robust minimax LQR control of multivariable nonlinear systems with application to hypersonic flight

For a class of multi‐input and multi‐output nonlinear uncertainty systems, a novel approach to design a nonlinear controller using minimax linear quadratic regulator (LQR) control is proposed. The proposed method combines a feedback linearization method with the robust minimax LQR approach in the presence of time‐varying uncertain parameters. The uncertainties, which are assumed to satisfy a certain integral quadratic constraint condition, do not necessarily satisfy a generalized matching condition. The procedure consists of feedback linearization of the nominal model and linearization of the remaining nonlinear uncertain terms with respect to each individual uncertainty at a local operating point. This two‐stage linearization process, followed by a robust minimax LQR control design, provides a robustly stable closed loop system. To demonstrate the effectiveness of the proposed approach, an application study is provided for a flight control problem of an air‐breathing hypersonic flight vehicle (AHFV), where the outputs to be controlled are the longitudinal velocity and altitude, and the control variables are the throttle setting and elevator deflection. The proposed method is used to derive a linearized uncertainty model for the longitudinal motion dynamics of the AHFV first, and then a robust minimax LQR controller is designed, which is based on this uncertainty model. The controller is synthesized considering seven uncertain aerodynamic and inertial parameters. The stability and performance of the synthesized controller is evaluated numerically via single scenario simulations for particular cruise conditions as well as a Monte‐Carlo type simulation based on numerous cases. It is observed that the control scheme proposed in this paper performs better, especially from the aspect of robustness to large ranges of uncertainties, than some controller design schemes previously published in the literature. Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Thermoluminescence Dating and the Problem of Geochemical Evolution of Sediments — A Case Study: The Mousterian Levels at Hayonim

The thermoluminescence dating of burnt flints has become a major tool in the elaboration of the chronology of human settlements of the last half a million years. The reliability of an age estimate depends to a great extent on the accuracy with which the internal and external radiation dose rates prevailing during the duration of burial can be determined. While determining the internal dose rate is relatively straightforward, the same cannot be said of the external, particularly if the sediment surrounding the flints is mineralogically heterogeneous or has undergone diagenetic changes during prolonged burial. In this article we show some examples of the problems confronted when one attempts to determine the external dose rates experienced by flints buried in a relatively heterogeneous environment of sediments, such as those sampled at the Middle Paleolithic occupation levels at Hayonim (Israel) which show evidence of past mineralogical evolution. The impact of changes produced by leaching and chemical reactions between the components of hearth ashes on the radioisotopic composition of the sediment and consequently the environmental dose rates were examined by subjecting several distinct sediment layers to thorough mineralogical, radiochemical, and dosimetric analyses. The problems of external dose-rate determinations in mineralogically heterogeneous sediments are examined, particularly in those consisting of variable amounts of siliceous aggregates, apatite, and other phosphorus-rich minerals produced by diagenetic reactions with bone residues.     

Recent progress in road and lane detection: a survey

The problem of road or lane perception is a crucial enabler for advanced driver assistance systems. As such, it has been an active field of research for the past two decades with considerable progress made in the past few years. The problem was confronted under various scenarios, with different task definitions, leading to usage of diverse sensing modalities and approaches. In this paper we survey the approaches and the algorithmic techniques devised for the various modalities over the last 5 years. We present a generic break down of the problem into its functional building blocks and elaborate the wide range of proposed methods within this scheme. For each functional block, we describe the possible implementations suggested and analyze their underlying assumptions. While impressive advancements were demonstrated at limited scenarios, inspection into the needs of next generation systems reveals significant gaps. We identify these gaps and suggest research directions that may bridge them.     

Maximization of total surface area of Pt-SnO<Subscript>2</Subscript>/Al<Subscript>2</Subscript>O<Subscript>3</Subscript> catalyst by the Taguchi method

The maximization of the total surface area of Pt-SnO₂/Al₂O₃ catalyst was studied by using the Taguchi method of experimental design. The catalysts were prepared by sol-gel method. The effects of HNO₃, H₂O and aluminum nitrate concentrations and the stirring rate on the total surface area were studied at three levels of each. L₉ orthogonal array leading nine experiments was used in the experimental design. The parameter levels that give maximum total surface area were determined and experimentally verified. In the range of conditions studied it was found that, medium levels of HNO₃ and H₂O concentration and lower levels of aluminum nitrate concentration and stirring rate maximize the total surface area.