A bio-inspired gelatin-based pH- and thermal-sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

Gelatin (Gel)-based pH- and thermal-responsive magnetic hydrogels (MH-1 and MH-2) were designed and developed as novel drug delivery systems (DDSs) for cancer chemo/hyperthermia therapy. For this goal, Gel was functionalized with methacrylic anhydride (GelMA), and then copolymerized with (2-dimethylaminoethyl) methacrylate (DMAEMA) monomer in the presence of methacrylate-end capped magnetic nanoparticles (MNPs) as well as triethylene glycol dimethacrylate (TEGDMA; as crosslinker). Afterward, a thiol-end capped poly(N-isopropylacrylamide) (PNIPAAm-SH) was synthesized through an atom transfer radical polymerization technique, and then attached onto the hydrogel through “thiol-ene” click grafting. The preliminary performances of developed MHs for chemo/hyperthermia therapy of human breast cancer was investigated through the loading of doxorubicin hydrochloride (Dox) as an anticancer agent followed by cytotoxicity measurement of drug-loaded DDSs using MTT assay by both chemo- and chemo/hyperthermia-therapies. Owing to porous morphologies of the fabricated magnetic hydrogels according to scanning electron microscopy images and strong physicochemical interactions (e.g., hydrogen bonding) the drug loading capacities of the MH-1 and MH-2 were obtained as 72 ± 1.4 and 77 ± 1.8, respectively. The DDSs exhibited acceptable pH- and thermal-triggered drug release behaviors. The MTT assay results revealed that the combination of hyperthermia therapy and chemotherapy has synergic effect on the anticancer activities of the developed DDSs.     

A Case Study on Fatigue Failure of a Transmission Gearbox Input Shaft

In this paper, a root cause analysis of premature failure of a gearbox input shaft, manufactured of AISI 1045-H, was performed through standard procedures for failure analysis. Shaft failed on cross oil hole through a helical fracture and therefore did not meet bogie 100,000 cycles during the verification with 10 Hz frequency cyclic testing. The fracture in the oil hole implied evidence of fatigue (i.e., beach marks on the fracture surface were clearly visible). Prior to improving the fatigue life and suggesting required remedial actions, mechanism of failure has to be understood, especially the initiating point of cracking. To this end, chemical analysis, microstructural characterization, fractography, hardness measurements, and finite element simulation were used to assess the nature of fracture in detail. The fractography analysis showed that fatigue beach marks originate from transition zone of the case on the cross oil hole. This is possibly due to the fact that torsional strength in this area is lower than torsional fatigue strength which leads to fatigue crack initiation, crack growth, and final fracture. At the end of this paper, proper remedial actions have been proposed.     

Characterization of titania thin films grown by dip-coating technique

A dip-coating technique was employed to prepare anatase phase of titania thin films. Fluorine doped tin oxide substrates were used to prepare titania thin films. The samples were annealed at 550 °C for 18 h. X-ray diffraction results revealed the amorphous and anatase phases of TiO₂ for as-synthesized and annealed samples, respectively. The crystallite size of anatase TiO₂ thin films was almost 25 nm for annealed samples. UV–visible confirmed the energy band gap 3.86 and 3.64 eV for as-prepared and calcinated titania thin films. The reduction in the energy band gap could be due to the change in crystallization and agglomeration of small grains after calcination. The morphology of the prepared films was investigated by field emission scanning electron microscopy which demonstrated the agglomeration of spherical particles of TiO₂ with average particle size of about 30 nm. The molecular properties (chemical bonding) of the samples were investigated by means of Fourier Transform Infrared (FTIR) spectroscopy. FTIR analysis exhibited the formation of titania, functional group OH, hydroxyl stretching vibrations of the C–OH groups, bending vibration mode of H–O–H, alkyl C–H stretch, stretching band of Ti–OH, CN asymmetric band stretching, and C=O saturated aldehyde.     

High Gain Modified Dual-Band and Dual-Circularly Polarized Array Antenna

Wireless Personal Communications - A novel design of double-layer dual-band circularly polarized array antennas (DDCPAAs) is presented in this paper. First, a DDCP single antenna is introduced as...     

Energy use efficiency and economical analysis of almond production: a case study in Chaharmahal-Va-Bakhtiari province,Iran

The aim of this study was to analyse input–output energy and economical assessment of almond production in three age groups of orchards (group I 6–10, group II 11–15 and group III 16–20 years old) in Chahrmahal-Va-Bakhtiari province, Iran. Data for almond production were collected by administering questionnaire in face-to-face interviews from the orchards selected based on random sampling method during a 3-year period. The results showed that 57,027.13, 60,341.14 and 61,640.43 MJ ha^?1 energy was consumed by group I, group II and group III, respectively. The most energy input was consumed by electricity, followed by chemical fertilizer. Energy indices were calculated, and the results revealed that energy efficiency was 0.62, 1.12 and 0.81 in the triple groups of orchards, respectively. Economical assessment showed that total production cost of almond in group I, II and III was $4547.54, $5799.26 and $5687.05 ha^?1, respectively. In all orchard groups, the shares of variable and fixed production costs found to be same nearly. Net return for almond production was $14,516.22, $30,735.19 and $21,395.57ha^?1, respectively. According to the research results, it was concluded that although almond production in the study region was not an efficient process in terms of energy consumption, it was a profitable agricultural operation.     

Infrared thin layer drying of saffron (Crocus sativus L.) stigmas: Mass transfer parameters and quality assessment

Saffron is the most precious and expensive agricultural product. A dehydration treatment is necessary to convert Crocus sativus L. stigmas into saffron spice. To the best of our knowledge, no information on mass transfer parameters of saffron stigmas is available in the literature. This study aimed at investigating the moisture transfer parameters and quality attributes of saffron stigmas under infrared treatment at different temperatures(60,70, …, 110 °C). It was observed that the dehydration process of the samples occurred in a short accelerating rate period at the start followed by a falling rate period. The effective moisture diffusivity and convective mass transfer coefficient were determined by using the Dincer and Dost model. The diffusivity values varied from1.1103 × 10~(-10)m~2·s~(-1)to 4.1397 × 10~(-10)m~2·s~(-1) and mass transfer coefficient varied in the range of 2.6433 × 10~(-7)–8.7203 × 10~(-7)m·s~(-1). The activation energy was obtained to be 27.86 k J·mol~(-1). The quality assessment results showed that the total crocin content increased, when the temperature increased up to90 °C but, in higher temperatures, the amount of crocin decreased slightly. The total safranal content of the samples decreased slightly when drying temperature increased from 60 °C to 70 °C and then continuously increased up to 110 °C. Also, the amount of picrocrocin increased from 83.1 to 93.3 as the drying temperature increased from 60 °C to 100 °C.     

Study on Wear Model and Adhesive Wear Mechanism of Brass under Boundary Lubrication

Protection of Metals and Physical Chemistry of Surfaces - The tribological tests of brass and steel are carried out on an in-situ tribometer. The Stribeck curve illustrates that the roughness and...     

The effects of thermo-mechanical parameters on the microstructure of Thixocast A356 aluminum alloy

In general, semi solid Thixocast (A356) alloys are consisted of extensive globular -Al regions, which are surrounded by eutectic (β) phase. The better formability, higher toughness and structure free porosities, gas cavities and shrinkages are the important advantages of this globular structure. In addition the thermo-mechanical processing is known as one of the most effective processing techniques to control the final mechanical properties. Accordingly, in present work the effects of strain rate and the deformation temperature on the microstructure (morphology of Si phase) of Thixocast aluminum (A356) alloy have been studied. In this regard, hot compression tests at 450, 500 and 540 °C with strain rate of 0.0001, 0.0005, 0.001 and 0.01 s⁻¹ have been performed. The results showed an extensive change in the morphology of eutectic Si fibers through breaking and spheroidization processes.     

An investigation to the effect of deformation-heat treatment cycle on the eutectic morphology and mechanical properties of a Thixocast A356 alloy

The influences of deformation, heat treatment temperature and holding time on morphology and size distribution of Si containing eutectic phases of Thixocast Al-7Si-0.4 Mg alloy were investigated. The novel thermo-mechanical treatment consisted of initial cold working practice followed by a solution heat treatment at 540 °C for durations ranging from 2 min to 120 min followed by water quenching. Optical and scanning electron microscopes were used to study the influence of process parameters on microstructure evolution. Also, final mechanical properties were investigated using hardness test. The results indicate that, under appropriate conditions it is possible to achieve an ultrafine grain microstructure with the eutectic Si fibers fragmented and spheroidized in the entire microstructure. It was also found that, an agglomeration of sphrodized particles occurs and is governed by Ostwald ripening mechanism.     

Soluble soybean polysaccharide/TiO2 nanocomposites: Biological activity,release behavior,biodegradability, and biosafety

This study aimed to produce and characterize eco-friendly SSPS nanocomposites incorporated with various concentrations of TiO₂ nanoparticles (NPs) (1%, 3%, and 7%). The antimicrobial activity of the nanocomposite films against five strains of pathogenic bacteria was examined. Salmonella typhi PTCC 1609 was the most sensitive species to TiO₂ NPs at concentrations equal to the synthetic antibiotic. The migration of TiO₂ to ethanol and acetic acid, as two food simulants increased when the initial nano-TiO₂ content increased. The release profiles for TiO₂ in two simulants of ethanol and acetic acid indicated a non-Fickian release, and the release kinetics were concentration-dependent. SSPS/TiO₂ nanocomposites degraded easily and thus have the potential to be applied as an eco-friendly packaging system. Oral administration of doses of 1, 12.5, 25, 50, and 75 mg/kg TiO₂ revealed that the dose of 50 and 75 mg/kg increased malondialdehyde (p < .001) concentration in the liver tissue. In addition, it decreased glutathione (p < .001) concentration in the liver tissue.