Decision recommendations are a set of alternative options for clinical decisions (e.g., diagnosis, prognosis, treatment selection, follow-up, and prevention) that are provided to decision makers by knowledge-based Clinical Decision Support Systems (k-CDSS) as aids. We propose to follow a “reasoning over domain” approach for the generation of decision recommendations by gathering and inferring conclusions from production rules. In order to rationalize our approach, we present a specification that will sustain the logic models supported in the knowledge bases we use for persistence. We introduce first the underlying knowledge model and then the necessary extensions that will convey toward the solution of the reported needs. The starting point of our approach is the proposition of Reflexive Ontologies (RO). Here, we go a step further, proposing an extension of RO that includes the handling and reasoning that production rules provide. Our approach speeds up the recommendation generation process. 相似文献
In this work, two medium Mn steels (5.8 and 5.7 wt pct Mn) were subjected to a quenching and partitioning (Q&P) treatment employing a partitioning temperature which corresponded to the start of austenite reverse transformation (ART). The influence of a 1.6 wt pct Ni addition in one of the steels and cycle parameters on austenite stability and mechanical properties was also studied. High contents of retained austenite were obtained in the lower quenching temperature (QT) condition, which at the same time resulted in a finer microstructure. The addition of Ni was effective in stabilizing higher contents of austenite. The partitioning of Mn and Ni from martensite into austenite was observed by TEM–EDS. The partitioning behaviour of Mn depended on the QT condition. The lower QT condition facilitated Mn enrichment of austenite laths during partitioning and stabilization of a higher content of austenite. The medium Mn steel containing Ni showed outstanding values of the product of tensile strength (TS) and total elongation (TEL) in the lower QT condition and a higher mechanical stability of the austenite.
While patterning 2D metallic nanostructures are well established through different techniques, 3D printing still constitutes a major bottleneck on the way to device miniaturization. In this work a fluid phase phospholipid ink is used as a building block for structuring with dip-pen nanolithography. Following a bioinspired approach that relies on ink-spreading inhibition, two processes are presented to build 2D and 3D metallic structures. Serum albumin, a widely used protein with an innate capability to bind to lipids, is the key in both processes. Covering the sample surface with it prior to lipid writing, anchors lipids on the substrate, which ultimately allows the creation of highly stable 3D lipid-based scaffolds to build metallic structures. 相似文献
The integration of Clinical Decision Support Systems (CDSS) in nowadays clinical environments has not been fully achieved yet. Although numerous approaches and technologies have been proposed since 1960, there are still open gaps that need to be bridged. In this work we present advances from the established state of the art, overcoming some of the most notorious reported difficulties in: (i) automating CDSS, (ii) clinical workflow integration, (iii) maintainability and extensibility of the system, (iv) timely advice, (v) evaluation of the costs and effects of clinical decision support, and (vi) the need of architectures that allow the sharing and reusing of CDSS modules and services. In order to do so, we introduce a new clinical task model oriented to clinical workflow integration, which follows a federated approach. Our work makes use of the reported benefits of semantics in order to fully take advantage of the knowledge present in every stage of clinical tasks and the experience acquired by physicians. In order to introduce a feasible extension of classical CDSS, we present a generic architecture that permits a semantic enhancement, namely Semantic CDSS (S-CDSS). A case study of the proposed architecture in the domain of breast cancer is also presented, pointing some highlights of our methodology. 相似文献
The quenching and partitioning (Q&P) steels have shown to be promising candidates to be applied in fields where wear resistance is required. In this study, a medium and a high C steel are heat treated by Q&P and the resulting microstructure, hardness, and wear resistance are characterized. The mechanical stability of the austenite phase under wear test conditions is investigated. It is found that the stability of austenite is very high in the high C steel and decreases in the medium C steel. Additionally, the hardness and wear behavior of the Q&P-treated steels are compared with the results obtained for quenching and tempering (Q&T) treated samples, showing that, although the hardness of Q&P steels is quite lower, the obtained wear rates are similar. It means that in the studied Q&P steels, although the austenite transformation into martensite does not occur considerably, the presence of austenite might play a key role in the wear resistance. 相似文献
In this article we present the design and implementation of a mobile cardiac monitoring system oriented to patients in Phase II and III of cardiac rehabilitation. The complete monitoring system involves both hardware and software design perspectives. At the hardware level, we present a T-shirt with a 12-lead ECG system and an embedded inertial sensor for the monitoring of activity and energy expenditure. At the software level, a modular cloud platform performs data processing to detect relevant cardiac events and to provide advanced visualization capabilities. As a case study, we have implemented our system at the Cardiac Rehabilitation program at Donostia University Hospital (Spain). Finally, the validation of the 12-lead ECG recording system is also presented and discussed. 相似文献
This paper analyzes and compares different control tuning strategies for a variable speed wind energy conversion system (WECS) based on a permanent-magnet synchronous generator (PMSG). The aerodynamics of the wind turbine (WT) and a PMSG have been modeled. The control strategy used in this research is composed of three regulators, which may be based on either linear or nonlinear controllers. In this analysis, proportional-integral (PI) linear controllers have been used. Two different tuning strategies are analyzed and compared. The main goal is to enhance the overall performance by achieving a low sensitivity to disturbances and minimal overshoot under variable operating conditions. Finally, the results have been verified by an experimental WECS laboratory prototype. 相似文献
Ontology processing is arguably a time-consuming process with high associated computational costs. Query actions constitute a crucial part of the reasoning process and are a primary source of time consumption. Reflexive ontologies (ROs) is a novel approach intended to reduce time consumption problems while providing a fast reaction from ontology-based applications. In this article we present the implementation of a knowledge-based clinical decision support system (CDSS) for the diagnosis of Alzheimer's disease, which was the benchmark used to evaluate the impact of RO in the overall performance of the system. The implementation details and the definition of the implementation methodology are exposed in this article, along with the results of the evaluation. Some novel techniques that aim to optimize the performance of ROs are also presented with highlights of the test application introduced in our previous work. 相似文献