Middle cerebral artery main stem thrombosis in two siblings with familial thrombotic thrombocytopenic purpura

Idiopathic thrombotic thrombocytopenic purpura (TTP) is frequently complicated by microinfarcts in cerebral cortex and subcortical white matter. We describe two sisters who suffered massive hemispheric infarction due to thrombosis of the middle cerebral artery main stem during exacerbations of TTP. Acute TTP may be associated with intraluminal thrombosis of large-diameter arteries in addition to arterioles and capillaries.     

Pathogenesis of Mycobacterium bovis infection in cattle

This paper reviews the pathogenesis of Mycobacterium bovis infection in cattle, focusing on aspects relating to the host rather than the organism. A broad concept of pathogenesis has been considered and information is presented on sources and routes of infection, as well as the immune responses and pathology. In addition, data is presented on the excretion of M. bovis from tuberculous cattle.     

Nitrous oxide emission factors in conventionally and naturally simulated cattle urine patches

Nutrient Cycling in Agroecosystems - We quantified nitrous oxide emission factors (N2O EFs) for cattle urine patches established using two simulation methods: (1) a uniformly wetted area (UWA) and...     

Nitrogen dynamics during till and no-till pasture restoration sequences in Rondônia,Brazil

The clearing of tropical rain forest in the Amazon basin has created large areas of cattle pasture that are now declining in productivity. Practices adopted by ranchers to restore productivity to degraded pastures have the potential to alter soil N availability and gaseous N losses from soils. We examined how soil inorganic N pools, net N mineralization and net nitrification rates, nitrification potential and NO and N₂O emissions from soils of a degraded pasture responded to the following restoration treatments: (1) soil tillage followed by replanting of grass and fertilization, (2) no-till application of non-selective herbicide, planting of rice, harvest followed by no-till replanting of grass and fertilization, and (3) the same no-till sequence with soybeans instead of rice. Tillage increased soil NH₄⁺ and NO₃^? pools but NH₄⁺ and NO₃^? pools remained relatively constant in the control and no-till treatments. Cumulative rates of net N mineralization and net nitrification during the first 6 months after treatment varied widely but were hightest in the tilled treatment. Emissions of NO and N₂O fluxes increased with tillage and with N fertilization. There were no clear relationships among rates of N fertilizer application, net N mineralization, net nitrification, NO, N₂O and total N oxide emissions. Our results indicate that pasture restoration sequences involving tilling and fertilizing will increase emissions of N oxides, but the magnitude of the increase is likely to differ based on timing of fertilizer application relative to the presence of plants and the magnitude of plant N demand. Emissions of N oxides appear to be decreased by the use of restoration sequences that minimize reductions in pasture grass cover.     

Cold gas dynamic manufacturing: A non-thermal approach to freeform fabrication

This paper reports on the development of a novel freeform fabrication technique using a cold spray (CS) system. In the CS process, metallic powder particles are accelerated in a supersonic gas jet and impacted with a substrate at speeds in excess of 600 m/s. The non-melting nature of its deposition mechanism ensures that the sprayed material is free from thermally induced tensile stresses, while the underlying substrate remains unchanged. The process is seen as a viable method for additive manufacturing because of its high deposition rates and controllable spray jet. A process was developed to investigate the potential of non-thermal freeform fabrication and was coined Cold Gas Dynamic Manufacturing (CGDM). Here, additive and subtractive techniques were combined to enable the production of complex geometries. Whereas most CS facilities concentrate on the application of wear or corrosion-resistant coatings, CGDM is dedicated to the production of freeform components, whilst still retaining an inherent coating ability. The process can produce functional forms using novel manufacturing strategies that are unique to CS. This paper presents information on the process, and details the various strategies employed during component fabrication. It was possible to construct components from many materials, including titanium, which exhibited freeform surfaces, internal channels and embedded devices. A breakdown of the process economics is also provided, with and without helium recycling.     

Brute Force Polarization of 129Xe

Hyperpolarized ¹²⁹Xe has numerous applications in Nuclear magnetic resonance (NMR) and magnetic resonance imaging(MRI). As an alternative to the laser optical pumping method of production of hyperpolarized ¹²⁹Xe gas, we have investigated the brute force technique which uses a very high magnetic field and millikelvin temperatures. One obstacle to this technique is the extremely long spin lattice relaxation times of nuclei in solids at very low temperature. We exploit the fact that liquid ³He can be used as an effective relaxant to enable ¹²⁹Xe to be spin polarized on a high surface area substrate in a few hours. We are able to identify the contributions of different atomic layers to the magnetization by analyzing the ¹²⁹Xe NMR spectrum. Furthermore, the addition of ⁴He allows us to turn off the relaxation mechanism, thereby preserving the polarization. The technique could be applied to nuclei other than ¹²⁹Xe.     

Proposal of visual strength grading rules for Uruguayan pine timber

A previous database with bending and density data of 261 structural size specimens of currently produced Uruguayan slash pine and loblolly pine timber was adjusted to meet testing and characterization requirements of European standards. Visual parameters and mechanical properties for each specimen were evaluated and their relationship was statistically analyzed. Results suggested that all specimens can be grouped in one visual grade with engineered properties similar to those of European C14 strength class. Modulus of elasticity and characteristic bending strength were the defining properties for class assignation.     

A methodology for user directed search in evolutionary design

A designer should be able to express their intentions with a design tool. This work describes a methodology that enables the architect to directly interact with the encoding of designs they find aesthetically pleasing. Broadening interaction beyond simple evaluation increases the amount of feedback and bias a user can apply to the search. Increased feedback will have the effect of directing the algorithm to more fruitful areas of the search space. We conduct trials on two interfaces for making localised changes to a design in order to evaluate if the user is capable of directing search. In addition, an examination of the locality of changes made by the users provides an insight into how they explore the search space. The results show that a suitably designed interface is capable of directing search and that the participants used different magnitudes of change during directed search.