Transrectal prostatic echography in the study of hemospermia. An assessment of an 85-patient case load

Eighty-five patients with hemospermia were examined with blood tests, sperm culture, transrectal US (TRUS) and cystourethroscopy. Blood tests and sperm culture demonstrated bacterial inflammation in 48 patients (56.47%). At cystourethroscopy, the urethra was normal or hyperemic in all patients. TRUS demonstrated 40 cases (47.05%) of periurethral calcifications and also with calcifications in the two glandular lobes. TRUS also demonstrated prostatic inflammation in progress or its outcome in 21 patients (24.70%), ectasia and seminal vesicle inflammation in 10 patients (11.76%), a prostatic tumor in 3 patients (3.52%). No patient had cysts, stones or cancers in the seminal vesicles. In 11 patients (12.94%), no specific cause of hemospermia was detected, even though 4 of these patients (4.70%) had received anticoagulants for former heart ischemia. Benign prostatic hypertrophy was found in 44 patients (51.76%) but we did not consider it a possible cause of hemospermia because of the high frequency of this condition in the male population. To conclude, TRUS could demonstrate the cause of hemospermia in most of our patients, which makes us suggest it as the diagnostic technique of choice in the patients with ejaculatory conditions, after clinical exams and laboratory tests, because it allows to study the prostate, the seminal vesicles and the urethra.     

A fast algorithm for complex discord searches in time series: HOT SAX Time

Time series analysis is quickly proceeding towards long and complex tasks. In recent years, fast approximate algorithms for discord search have been proposed in order to compensate for the increasing size of the time series. It is more interesting, however, to find quick exact solutions. In this research, we improved HOT SAX (Heuristically Ordered Time series using Symbolic Aggregate ApproXimation) by exploiting two main ideas: the warm-up process, and the similarity between sequences close in time. These improvements can reduce the size of the discord search space by orders of magnitude when compared with HOT SAX. The resulting algorithm, called HOT SAX Time (HST), has been validated with real and synthetic time series, and successfully compared with HOT SAX, RRA (Rare Rule Anomaly), SCAMP (SCAlable Matrix Profile), and DADD (Disk Aware Discord Discovery). The complexity of a discord search has been evaluated with a new indicator, the cost per sequence (cps), which allows one to compare searches on time series of different lengths. Numerical evidence suggests that two conditions are involved in determining the complexity of a discord search in a non-trivial way: the length of the discords, and the noise/signal ratio. This is the first exact discord search algorithm that has been demonstrated being more than 100 times faster than HOT SAX.

     

Soybean germ oil inhibits oxidosqualene cyclase in 3T3 fibroblasts

Soybean germ oil (SGO) could take an important place among nutraceuticals if the finding were confirmed that a daily intake of SGO helps to maintain a normal level of serum cholesterol. Adapting the rice milling technology to the soybean refining process, we achieved a rapid and efficient separation of soybean bran and cotyledon from the hypocotyle. Our soybean germ was no less than 95% hypocotyle. SGO obtained from it by typical hexane extraction was very rich in tocopherols (total content 4.35 g/kg) and phytosterols (β‐sitosterol 57.4%, Δ‐7‐stigmastenol 20.2%, Δ‐7‐avenasterol 6.8%, stigmasterol 6.2%, campesterol 5.4%, Δ‐7‐campesterol 1.2%, Δ‐5‐avenasterol 0.95%, etc.; total sterols 44.3 g/kg). The most prominent fatty acids were linoleic (56.2%), linolenic (15.5%) and oleic acid (10.6%). Although isoflavones abound in soybean germ (17.7 g/kg), only traces of them passed into the hexane extract (7 mg/kg). In murine 3T3 fibroblasts, SGO was found to reduce the incorporation of [¹⁴C]acetate into sterols, by inhibiting oxidosqualene cyclase.     

Reduction in urinary prostaglandin excretion in the premenstrual syndrome

The purpose of the present work was to study some factors involved in renal handling of salt and water in the premenstrual syndrome (PMS), in which salt and water retention is frequently observed. In 18 women with PMS and in 18 healthy women we studied the levels of cyclic adenosine monophosphate, aldosterone, prostaglandin E2, prostaglandin F2 alpha and kallikrein in urinary samples collected during the luteal phase. There was no difference between the two groups regarding sodium, aldosterone and kallikrein urinary excretion. In the PMS group there was a significant reduction in urinary excretion of cyclic adenosine monophosphate, prostaglandin E2 and prostaglandin F2 alpha with respect to the control group. At multivariate analysis sodium urinary excretion proved not to be the same as the model validated in healthy women. There may be different renal handling of water and electrolytes during the luteal phase of the menstrual cycle in women with PMS.