Performance engineering and topological design of metro WDM opticalnetworks using computer simulation

This paper demonstrates the use of computer simulation for topological design and performance engineering of transparent wavelength-division multiplexing metropolitan-area networks. Engineering of these networks involves the study of various transport-layer impairments such as amplifier noise, component ripple, chirp/dispersion, optical crosstalk, waveform distortion due to filter concatenation, fiber nonlinearities, and polarization effects. A computer simulation methodology composed of three main simulation steps is derived and implemented. This methodology obtains performance estimations by applying efficient wavelength-domain simulations on the entire network topology, followed by time-/frequency-domain simulations on selected paths of the network and finally Q-budgeting on an identified worst case path. The above technique provides an efficient tool for topological design and network performance engineering. Accurate simulation models are presented for each of the performance impairments, and the computer simulation methodology is used for the design and engineering of a number of actual metro network architectures     

Improving the performance of passive network monitoring applications with memory locality enhancements

Passive network monitoring is the basis for a multitude of systems that support the robust, efficient, and secure operation of modern computer networks. Emerging network monitoring applications are more demanding in terms of memory and CPU resources due to the increasingly complex analysis operations that are performed on the inspected traffic. At the same time, as the traffic throughput in modern network links increases, the CPU time that can be devoted for processing each network packet decreases. This leads to a growing demand for more efficient passive network monitoring systems in which runtime performance becomes a critical issue.In this paper we present locality buffering, a novel approach for improving the runtime performance of a large class of CPU and memory intensive passive monitoring applications, such as intrusion detection systems, traffic characterization applications, and NetFlow export probes. Using locality buffering, captured packets are being reordered by clustering packets with the same port number before they are delivered to the monitoring application. This results in improved code and data locality, and consequently, in an overall increase in the packet processing throughput and decrease in the packet loss rate. We have implemented locality buffering within the widely used libpcap packet capturing library, which allows existing monitoring applications to transparently benefit from the reordered packet stream without modifications. Our experimental evaluation shows that locality buffering improves significantly the performance of popular applications, such as the Snort IDS, which exhibits a 21% increase in the packet processing throughput and is able to handle 67% higher traffic rates without dropping any packets.     

Conversion of a benign lymphoepithelial salivary gland lesion to lymphocytic lymphoma during dilantin therapy: correlation with dilantin-induced lymphocyte transformation in vitro

A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.     

Entropy maximisation and open queueing networks with priorities and blocking

A review is carried out on the characterisation and algorithmic implementation of an extended product-form approximation, based on the principle of maximum entropy (ME), for a wide class of arbitrary finite capacity open queueing network models (QNMs) with service and space priorities. A single server finite capacity GE/GE/1/N queue with R (R>1) distinct priority classes, compound Poisson arrival processes (CPPs) with geometrically distributed batches and generalised exponential (GE) service times is analysed via entropy maximisation, subject to suitable GE-type queueing theoretic constraints, under preemptive resume (PR) and head-of-line (HOL) scheduling rules combined with complete buffer sharing (CBS) and partial buffer sharing (PBS) management schemes stipulating a sequence of buffer thresholds {N=(N₁,…,N_R),0<N_i≤N_i−1,i=2,…,R}. The GE/GE/1/N queue is utilised, in conjunction with GE-type first two moment flow approximation formulae, as a cost-effective building block towards the establishment of a generic ME queue-by-queue decomposition algorithm for arbitrary open QNMs with space and service priorities under repetitive service blocking with random destination (RS-RD). Typical numerical results are included to illustrate the credibility of the ME algorithm against simulation for various network topologies and define experimentally pessimistic GE-type performance bounds. Remarks on the extensions of the ME algorithm to other types of blocking mechanisms, such as repetitive service blocking with fixed destination (RS-FD) and blocking-after-service (BAS), are included.     

Antenna applications of negative-refractive-index transmission-line structures

A number of new antenna-related applications that have recently been developed at the University of Toronto based on the concept of negative-refractive-index transmission-line metamaterials are reviewed. These include non-radiating phase-shifting lines that can produce either a positive or a negative phase-shift while exhibiting a broadband linear phase response, as well as compact and broadband series power dividers and associated planar series-fed printed dipole arrays with reduced beam-squinting. Moreover, a fully printed electrically small ring antenna featuring vertical polarisation and good radiation efficiency is also described     

MRE hierarchical decomposition of general queueing network models

Summary The principle of Minimum Relative Entropy (MRE), given fully decomposable subset and aggregate mean queue length, utilisation and flow-balance constraints, is used in conjunction with asymptotic connections to infinite capacity queues, to derive new analytic approximations for the conditional and marginal state probabilities of single class general closed queueing network models (QNMs) in the context of a multilevel variable aggregation scheme. The concept of subparallelism is applied to preserve the flow conservation and a universal MRE hierarchical decomposition algorithm is proposed for the approximate analysis of arbitrary closed queueing networks with single server queues and general service-times. Heuristic criteria towards an optimal coupling of network's units at each level of aggregation are suggested. As an illustration, the MRE algorithm is implemented iteratively by using the Generalised Exponential (GE) distributional model to approximate the service and asymptotic flow processes in the network. This algorithm captures the exact solution of separable queueing networks, while for general queueing networks it compares favourably against exact solutions and known approximations.This work is sponsored by the Science and Engineering Research Council (SERC), UK, under grant GR/F29271     

Effects of filter concatenation for directly modulated transmissionlasers at 2.5 and 10 Gb/s

We report computer simulation results of the effects on optical signal quality of passage through a cascade of wavelength division multiplexing (WDM) filters-multiplexers and demultiplexers-for directly modulated lasers with different chirp characteristics. In particular, lasers with transient or adiabatic chirp characteristics at 2.5 Gb/s and 10 Gb/s are investigated, and we find clear differences between the laser types with respect to filter concatenation effects. Filters with an optical bandwidth suitable for a 200-GHz channel-spacing system are considered, and we evaluate the system behavior as a function of laser frequency offset for a fixed number of filters. The reference network architecture used for the simulations is an optically transparent metropolitan scale network in which the WDM signals may be demultiplexed and then multiplexed again at multiple optical network elements. The signal quality is evaluated in terms of a distortion-induced eye-closure penalty as well as the excess attenuation or loss suffered. We find that transient chirp-dominated lasers show a generally symmetric distortion penalty response to laser frequency offset, whereas the response for adiabatic chirp dominated lasers is highly asymmetric. Furthermore, the extinction ratio for the latter class of lasers can be improved, in some cases, by the appropriate offset between laser and filter center frequencies     

Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo

There has been considerable interest in the potential role of growth factors in the initiation and development of cutaneous malignant melanoma (CMM). Platelet-derived growth factor (PDGF) has been shown to be secreted by melanoma cell lines and by metastatic melanoma in vivo. PDGF also has been reported to stimulate the development of tumour stroma and new blood vessels. We studied the expression of PDGF and its receptors by both immunohistochemistry (IHC) and in situ hybridization (ISH) in primary and metastatic melanoma and in normal skin specimens. Cryostat sections were incubated with 35S-labelled riboprobes and antibodies for PDGF-AA, PDGF-alpha receptor, PDGF-BB and PDGF-beta receptor. Both primary and metastatic melanoma exhibited significant expression of PDGF-AA, PDGF-BB and PDGF-alpha receptor by both IHC and ISH, compared with only background expression in normal skin. We did not observe expression of PDGF-beta receptor in melanoma. Our results suggest that PDGF may function as an autocrine growth factor, as well as an angiogenesis factor, in CMM tumour development. This expression of the PDGF-alpha receptor rather than the beta receptor may be unique among solid tumours.