全文获取类型
收费全文 | 933篇 |
免费 | 50篇 |
专业分类
电工技术 | 13篇 |
综合类 | 6篇 |
化学工业 | 237篇 |
金属工艺 | 7篇 |
机械仪表 | 47篇 |
建筑科学 | 24篇 |
能源动力 | 27篇 |
轻工业 | 125篇 |
水利工程 | 5篇 |
石油天然气 | 4篇 |
无线电 | 55篇 |
一般工业技术 | 132篇 |
冶金工业 | 84篇 |
原子能技术 | 15篇 |
自动化技术 | 202篇 |
出版年
2024年 | 1篇 |
2023年 | 8篇 |
2022年 | 6篇 |
2021年 | 63篇 |
2020年 | 29篇 |
2019年 | 32篇 |
2018年 | 25篇 |
2017年 | 30篇 |
2016年 | 44篇 |
2015年 | 24篇 |
2014年 | 35篇 |
2013年 | 67篇 |
2012年 | 66篇 |
2011年 | 66篇 |
2010年 | 50篇 |
2009年 | 36篇 |
2008年 | 35篇 |
2007年 | 39篇 |
2006年 | 27篇 |
2005年 | 33篇 |
2004年 | 19篇 |
2003年 | 25篇 |
2002年 | 22篇 |
2001年 | 13篇 |
2000年 | 13篇 |
1999年 | 16篇 |
1998年 | 15篇 |
1997年 | 31篇 |
1996年 | 20篇 |
1995年 | 9篇 |
1994年 | 11篇 |
1993年 | 9篇 |
1992年 | 6篇 |
1991年 | 5篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1987年 | 2篇 |
1986年 | 6篇 |
1985年 | 5篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有983条查询结果,搜索用时 171 毫秒
1.
F Pigozzi N Santori V Di Salvo A Parisi L Di-Luigi 《Canadian Metallurgical Quarterly》1997,20(6):505-509
OBJECTIVE: To estimate the frequency of perioperative morbidities in patients who underwent anesthesia and a surgical procedure with no preoperative laboratory testing. MATERIAL AND METHODS: We conducted an electronic database search of medical records of 56,119 patients who underwent surgical or diagnostic procedures and anesthesia at Mayo Clinic Rochester in 1994 and found 5,120 who had no laboratory tests done within 90 days before the procedure. From this group, we randomly selected 1,044 patients (87 from each month) to document the absence of preoperative tests, the presence of preexisting disease (by organ system), the type of anesthetic agent, and the outcomes and tests intraoperatively and postoperatively. RESULTS: The 1,044 patients ranged in age from 0 to 95 years (median age, 21). No deaths or major perioperative morbidities occurred (0.0%; exact 95% confidence interval, 0.00 to 0.35%). Although 10 patients underwent blood typing and screening for antibodies immediately preoperatively, no blood transfusions were necessary. Intraoperatively, 17 laboratory tests and 1 electrocardiogram were obtained, and 3 results were abnormal. Postoperatively, 42 blood tests and 2 electrocardiographic procedures were performed. Five of the 42 blood tests showed abnormal results (hemoglobin levels in 3, serum sodium in 1, and arterial blood gases in 1). One electrocardiogram showed normal findings, and the other revealed normal results except for premature ventricular contractions. No laboratory test done intraoperatively or postoperatively was found to change surgical or medical management substantially. One patient who had unanticipated blood loss during an outpatient procedure was admitted to the hospital for observation. CONCLUSION: All 1,044 patients, 97% of whom were relatively healthy, with no recent laboratory testing safely underwent anesthesia and an operation. We conclude that patients who have been assessed by history and physical examination and determined to have no preoperative indication for laboratory tests can safely undergo anesthesia and operation with tests obtained only as indicated intraoperatively and post-operatively. Current anesthetic and medical practices rapidly identify perioperative indications for laboratory evaluation as they arise. 相似文献
2.
Controllability of One Spin and Two Interacting Spins 总被引:1,自引:0,他引:1
Mathematics of Control, Signals, and Systems - ?We consider the problem of steering control for the systems of one spin ½ particle and two interacting spin ½ particles in an... 相似文献
3.
The paper presents a neural network model of the touch sensitivity circuit of the nematode Caenorhabditis elegans. We describe a serie of simulations in which neural networks are trained, using a genetic algorithm, to reproduce the habituation of the nematode's touch sensitive behavior. A lesion study of the network allows to make a direct comparison between the fine functioning of the model and the data collected in real organisms. The model accords well with the known neurobiological data and it suggests some hypotheses about the functioning of the neural circuit and of single neurons. 相似文献
4.
The problem of the non-causal inversion of linear multivariable discrete-time systems is analyzed in the geometric approach framework and is solved through the computation of convolution profiles which guarantee perfect tracking under the assumption of infinite-length preaction and postaction time intervals. It is shown how the shape of the convolution profiles is related to both the relative degree and the invariant zeros of the plant. A computational setting for the convolution profiles is derived by means of the standard geometric approach tools. Feasibility constraints are also taken into account. A possible implementation scheme, based on a finite impulse response system acting on a stabilized control loop, is provided. 相似文献
5.
6.
In this paper we analyze how supervised learning occurs in ecological neural networks, i.e. networks that interact with an
autonomous external environment and, therefore, at least partially determine with their behavior their own input. Using an
evolutionary method for selecting good teaching inputs we surprisingly find that to obtain a desired outputX it is better to use a teaching input different fromX. To explain this fact we claim that teaching inputs in ecological networks have two different effects: (a) to reduce the
discrepancy between the actual output of the network and the teaching input, (b) to modify the network's behavior and, as
a consequence, the network's learning experiences. Evolved teaching inputs appear to represent a compromise between these
two needs. We finally show that evolved teaching inputs that are allowed to change during the learning process function differently
at different stages of learning, first giving more weight to (b) and, later on, to (a). 相似文献
7.
AP Krapcho E Menta A Oliva R Di Domenico L Fiocchi ME Maresch CE Gallagher MP Hacker G Beggiolin FC Giuliani G Pezzoni S Spinelli 《Canadian Metallurgical Quarterly》1998,41(27):5429-5444
The synthesis and antitumor evaluation of 2, 5-disubstituted-indazolo[4,3-gh]isoquinolin-6(2H)-ones (9-aza-APs) are described. The key intermediates in the synthesis are benz[g]isoquinoline-5,10-diones which are substituted at positions 6 and 9 with groups of different nucleofugacity for SNAr displacements. The initial displacement of fluoride by a substituted hydrazine leads to the pyrazole analogues. Substitution of the remaining leaving group by an amine or BOC-protected amines leads to the 9-aza-APs 12. These analogues were converted into their maleate or hydrochloride salts 13. In two cases, namely, 13x and 13z, sidearm buildup was also employed in the synthetic pathway. In vitro evaluation of 9-aza-APs against the human colon tumor cell line LoVo uncovered for most of the compounds a cytotoxic potency lower than that of DuP-941 or mitoxantrone and comparable to that of doxorubicin. Only analogues 13c, 13n, and 13ff were as cytotoxic as DuP-941. Interestingly, while DuP-941 was highly cross-resistant in the LoVo cell line resistant to doxorubicin (LoVo/Dx), the 9-aza-APs carrying a distal lipophilic tertiary amine moiety in both chains were capable of overcoming the MDR resistance induced in this cell line. The 9-aza-APs show outstanding in vivo antitumor activity against both systemic P388 murine leukemia and MX-1 human mammary carcinoma transplanted in nude mice. At their optimal dosages, congeners 13a-c, 13f, 13n, 13q, 13x, and 13dd were highly effective against P388 leukemia with T/C% of 200-381, while the T/C% value of DuP-941 was 147. In the MX-1 tumor model, 24 compounds elicited percentages of tumor weight inhibitions (TWI) ranging from 50% to 99%. Congeners 13d, 13k, 13l, 13x, 13z, and 13ee emerged as the most effective ones, with TWI% 96, simliar to that of DuP-941 (TWI% = 95). On the basis of their efficacy profile in additional experimental tumors and lack of cardiotoxicity in preclinical models, two congeners have surfaced as potential clinical candidates. 相似文献
8.
Domenico Ferrari 《Multimedia Systems》1998,6(3):179-185
The research done by the Tenet Group in multimedia networking has reached a point where it may be useful to reflect on the
significance of its results for the current debate on how integrated-services internetworks should be designed. Such reflections
constitute the main subject of this paper. The principles of the work and the conclusions reached so far by the Tenet researchers
are discussed in the light of the conflict between the two major technologies being proposed to build future information infrastructures:
namely, the Internet and the ATM technologies. The Tenet approach suggests one feasible way for resolving the conflict to
the advantage of all the users of those infrastructures. This paper discusses various fundamental aspects of integrated-services
network design: the choice of the service model, the type of charging policy to be adopted, and the selection of a suitable
architecture. 相似文献
9.
10.
Ilaria Zuliani Chiara Lanzillotta Antonella Tramutola Eugenio Barone Marzia Perluigi Serena Rinaldo Alessio Paone Francesca Cutruzzol Francesco Bellanti Matteo Spinelli Francesca Natale Salvatore Fusco Claudio Grassi Fabio Di Domenico 《International journal of molecular sciences》2021,22(7)
The disturbance of protein O-GlcNAcylation is emerging as a possible link between altered brain metabolism and the progression of neurodegeneration. As observed in brains with Alzheimer’s disease (AD), flaws of the cerebral glucose uptake translate into reduced protein O-GlcNAcylation, which promote the formation of pathological hallmarks. A high-fat diet (HFD) is known to foster metabolic dysregulation and insulin resistance in the brain and such effects have been associated with the reduction of cognitive performances. Remarkably, a significant role in HFD-related cognitive decline might be played by aberrant protein O-GlcNAcylation by triggering the development of AD signature and mitochondrial impairment. Our data support the impairment of total protein O-GlcNAcylation profile both in the brain of mice subjected to a 6-week high-fat-diet (HFD) and in our in vitro transposition on SH-SY5Y cells. The reduction of protein O-GlcNAcylation was associated with the development of insulin resistance, induced by overfeeding (i.e., defective insulin signaling and reduced mitochondrial activity), which promoted the dysregulation of the hexosamine biosynthetic pathway (HBP) flux, through the AMPK-driven reduction of GFAT1 activation. Further, we observed that a HFD induced the selective impairment of O-GlcNAcylated-tau and of O-GlcNAcylated-Complex I subunit NDUFB8, thus resulting in tau toxicity and reduced respiratory chain functionality respectively, highlighting the involvement of this posttranslational modification in the neurodegenerative process. 相似文献