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1.
Knaust Thiemo Felnhofer Anna Kothgassner Oswald D. Hllmer Helge Gorzka Robert-Jacek Schulz Holger 《Virtual Reality》2022,26(3):925-938
Virtual Reality - It is generally accepted that natural environments reduce stress and improve mood. Since access to natural environments is sometimes limited, virtual natural environments,... 相似文献
2.
Sarah Gilgunn Keefe Murphy Henning Stckmann Paul J. Conroy T. Brendan Murphy R. William Watson Richard J. OKennedy Pauline M. Rudd Radka Saldova 《International journal of molecular sciences》2020,21(23)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies. 相似文献
3.
Henning Fernau 《Acta Informatica》1997,34(11):837-857
4.
5.
Henning H. Mikkelsen Jens Oddershede John R. Sabin Ejvind Bonderup 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》1995,100(4):451-457
We derive a Bethe formula for the stopping of swift ions by target molecules oriented with respect to the beam. The theory is characterized by a directional mean excitation energy formed from transition energies and dipole matrix elements. The expression for the mean excitation energy is similar to the one for an isotropic sample but the dipole matrix elements corresponding to the various transition moment directions carry unequal weights which depend on the orientation of the molecule with respect to the beam. For a large class of molecules, the logarithm of the mean excitation energy is linear in sin2 θ, where θ denotes the angle between the beam and the principal molecular axis. We illustrate the properties of the theory in the simple case of a diatomic molecule. 相似文献
6.
Johan P. Hansen Henning Stichtenoth 《Applicable Algebra in Engineering, Communication and Computing》1990,1(1):67-77
We construct a series of algebraic geometric codes using a class of curves which have many rational points. We obtain codes of lengthq
2 over
q
, whereq = 2q
0
2
andq
0 = 2
n
, such that dimension + minimal distance q
2
+ 1 – q
0
(q – 1). The codes are ideals in the group algebra
q
[S], whereS is a Sylow-2-subgroup of orderq
2 of the Suzuki-group of orderq
2
(q
2
+ 1)(q – 1). The curves used for construction have in relation to their genera the maximal number of
GF
q
-rational points. This maximal number is determined by the explicit formulas of Weil and is effectively smaller than the Hasse—Weil bound.Supported by Deutsche Forschungsgemeinschaft while visiting Essen University 相似文献
7.
Werner Strohmaier Henning Klostermeyer Paul Deuritz Erich Windhab 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1992,194(6):531-535
Summary Current texture-measuring instruments and a recently developed measuring method (two-dimensional measuring of the force necessary to spread a sample) were compared in measuring the spreadability of processed cheese. How far subjective assessment by a qualified panel correlates with the instrumental results in determining spreadability and firmness was also investigated. Samples of processed cheese with various consistencies were measured by an Universal testing machine, a buttermeasuring instrument (DIN 10331), a rotational-type rheometer (oscillation mode) and a two-dimensional force measuring instrument. The evaluation of the results shows that an oscillating rheometer is most suitable to measure the spreadability of processed cheese; the correlation coefficient (r) between the dynamic Weissenberg number, calculated from parameters of the rheometer, and the subjective judgement by the panel wasr=0.91. For the determination of firmness the two-dimensional force measuring instrument is most suitable. The correlation coefficient between the parameter tangential energy (S
t) and the sensorially evaluated firmness wasr=0.95.
Vergleich verschiedener Bestimmungsmethoden für die Streichfähigkeit und Festigkeit von Schmelzkäse
Zusammenfassung Verschiedene gebräuchliche Meßinstrumente und ein neu entwickeltes Gerät zur zweidimensionalen Messung der Kräfte, die zum Ausstreichen einer Probe erforderlich sind, wurden vergleichend zur Charakterisierung der Streichfähigkeit von Schmelzkäse erprobt. Dabei wurde auch geprüft, inwieweit die subjektiven Beurteilungen eines qualifizierten Prüferpanels mit den Meßwerten für Streichfähigkeit und Festigkeit korrelierten. Gemessen wurde mit einer Universalprüfmaschine, dem Butterprüfgerät (DIN 10331), einem Rotationsrheometer und mit dem zweidimensional registrierenden Kraftmeßgerät. Dabei zeigte sich, daß das Rheometer im oscillierenden Modus die Streichfähigkeit am besten zu charakterisieren vermag. Die Korrelation zwischen den Rheometerwerten, berechnet als dynamische Weissenbergzahl, und den sensorisch ermittelten Werten für die Streichfähigkeit betrugr=0,91. Zur Bestimmung der Festigkeit ist das zweidimensional registrierende Kraftmeßgerät am besten geeignet, was sich in einem Korrelationskoeffizienten vonr=0,95 zwischen dem ParameterS t und den im Sensoriktest ermittelten Werten für dieFestigkeit ausdrückt.相似文献
8.
TIBER II is designed to be a minimum size and cost candidate for an international Engineering Test Reactor. High-current density Nb3Sn superconducting magnets with radiation-tolerant polymide insulation is combined with a minimum thickness tungsten inbored shield and a common, external vacuum boundary to minimize the inner radial build of the tokamak core. This results in a major radius of 3 m, compared to 5 m for previous ETR designs such as INTOR, with correspondingly lower costs expected. Cyclic stress fatigue limits the number of pulses so that steady-state current drive, based on a combination of neutral beams, lower hybrid and ECH, is designed to achieve reactor-relevant nuclear testing conditions (Fluence 3MW yr/m2, rwall > 1 MW/m2 in steady state).This report is abstracted from a more complete information document UCID-20863 with numerous authors. See Ref. l for complete credits. 相似文献
9.
Luiza Ghila Thomas Aga Legy Andreas Frslev Mathisen Shadab Abadpour Joao A. Paulo Hanne Scholz Helge Rder Simona Chera 《International journal of molecular sciences》2021,22(7)
The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms governing these processes is, thus, extremely valuable for managing the disease progression. Extracellular glucose is known to influence cell identity by impacting the redox balance. Here, we use global proteomics and pathway analysis to map the response of differentiating human pancreatic progenitors to chronically increased in vitro glucose levels. We show that exogenous high glucose levels impact different protein subsets in a concentration-dependent manner. In contrast, regardless of concentration, glucose elicits an antipodal effect on the proteome landscape, inducing both beneficial and detrimental changes in regard to achieving the desired islet cell fingerprint. Furthermore, we identified that only a subgroup of these effects and pathways are regulated by changes in redox balance. Our study highlights a complex effect of exogenous glucose on differentiating pancreas progenitors characterized by a distinct proteome signature. 相似文献
10.
Elvira S. Sandin Julica Folberth Helge Müller-Fielitz Claus U. Pietrzik Elisabeth Herold Thomas E. Willnow Paul T. Pfluger Ruben Nogueiras Vincent Prevot Thomas Krey Markus Schwaninger 《International journal of molecular sciences》2021,22(9)
The mechanisms underlying the transport of leptin into the brain are still largely unclear. While the leptin receptor has been implicated in the transport process, recent evidence has suggested an additional role of LRP2 (megalin). To evaluate the function of LRP2 for leptin transport across the blood-brain barrier (BBB), we developed a novel leptin-luciferase fusion protein (pLG), which stimulated leptin signaling and was transported in an in vitro BBB model based on porcine endothelial cells. The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of LRP2 in brain endothelial cells and epithelial cells of the choroid plexus did not influence bodyweight, body composition, food intake, or energy expenditure of mice. These findings suggest that LRP2 at the BBB is not involved in the transport of leptin into the brain, nor in the development of obesity as has previously been described. 相似文献