Slip Control System for a Deep-Sea Mining Machine

Tracked vehicles capable of locomotion in the deep sea are used for manganese nodule mining. This requires specific technical solutions in various respects. Locomotion in the soft sea bed is one of them. For the Crawler to safely maneuver, an automatic drive mode with slip control of the driving tracks is essential. Based on experimental studies at IKS, University of Siegen, slip control for the NIOT-IKS mining machine has been developed and implemented. The experimental setup for the development of the slip control along with the logic of the automatic driving mode is described. The system is critically discussed and the test results and future work are briefly outlined. Note to Practitioners-The work is carried out as part of the polymetallic nodule mining program of the Government of India. The technique of slip control is a specific requirement for a tracked vehicle used in the deep sea. Slip is common in many vehicles-tracked and otherwise. Examples are steam engines in the early days and ordinary cars while negotiating slush or snow/ice and dozers working in soft soil. While these are manually controlled by drivers who have firsthand knowledge of the environmental conditions, in the case of a mining machine in deep sea, it has to be completely automatic and, hence, is challenging. The knowledge generated in this work could be effectively used by practitioners in other related areas of automobile engineering for updating their expertise. Also, similar techniques may be used for maneuvering vehicles sent to other planets     

Guidelines for management of left-sided prosthetic valve thrombosis: a role for thrombolytic therapy. Consensus Conference on Prosthetic Valve Thrombosis

OBJECTIVES: We sought to form a consensus recommendation for management of prosthetic valve thrombosis (PVT) from previous case and uncontrolled reports from a consensus of international specialists. BACKGROUND: PVT and thromboembolism relate to inadequate anticoagulation and valve type and location. PVT is suspected by history (dyspnea) and auscultation (muffled valve sounds or new murmurs) and confirmed by Doppler echocardiography showing a marked valve gradient. METHODS: A consensus conference was held to recommend management of left-sided PVT. RESULTS: Transesophageal Doppler echocardiography is used to visualize abnormal leaflet motion and the size, location and mobility of thrombus. Thrombolysis is used for high risk surgical candidates with left-sided PVT (New York Heart Association functional class III or IV) because cerebral thromboembolism may occur in 12% of patients. Duration of thrombolysis depends on resolution of pressure gradients and valve areas to near normal by Doppler echocardiography performed every few hours. Lysis is stopped after 72 or 24 h if there is no hemodynamic improvement (operation indicated). Heparin infusion with frequent measurement of activated partial thromboplastin time (aPTT) begins when aPTT is more than twice control levels and can be converted to warfarin (international normalized ratio [INR] 2.5 to 3.5) plus aspirin (81 to 100 mg/day). Patients in functional class I or II have lower surgical mortality, and those with large immobile thrombi on the prosthetic valve or left atrium have responded to endogenous lysis with combined subcutaneous heparin every 12 h (aPTT 55 to 80 s) plus warfarin (INR 2.5 to 3.5) for 1 to 6 months. Operation is advised for nonresponders or patients with mobile thrombi. CONCLUSIONS: Thrombolysis, followed by heparin, warfarin and aspirin, is advised for high risk surgical candidates with left-sided PVT.     

Parallel reduced area multipliers

As developed by Wallace and Dadda, a method for high-speed, parallel multiplication is to generate a matrix of partial products and then reduce the partial products to two numbers whose sum is equal to the final product. The resulting two numbers are then summed using a fast carry-propagate adder. This paper presents Reduced Area multipliers, which employ a modified reduction scheme that results in fewer components and less interconnect overhead than either Wallace or Dadda multipliers. This reduction scheme is especially useful for pipelined multipliers, because it minimizes the number of latches required in the reduction of the partial products. The reduction scheme can be applied to either unsigned (sign-magnitude) or two's complement numbers. Equations are given for determining the number of components and a method is presented for estimating the interconnect overhead for Wallace, Dadda, and Reduced Area multipliers. Area estimates indicate that for non-pipelined multipliers, the reduction in area achieved with Reduced Area multipliers ranges from 3.7 to 6.6 percent relative to Dadda multipliers, and from 3.8 to 8.4 percent relative to Wallace multipliers. For fully pipelined multipliers, the reduction in area ranges from 15.1 to 33.6 percent relative to Dadda multipliers, and from 2.9 to 9.0 percent relative to Wallace multipliers.     

HybMig: A Hybrid Approach to Dynamic Plan Migration for Continuous Queries

In data stream environments, the initial plan of a long-running query may gradually become inefficient due to changes of the data characteristics. In this case, the query optimizer generates a more efficient plan based on the current statistics. The online transition from the old to the new plan is called dynamic plan migration. In addition to correctness, an effective technique for dynamic plan migration should achieve the following objectives: 1) minimize the memory and CPU overhead of the migration, 2) reduce the duration of the transition, and 3) maintain a steady output rate. The only known solutions for this problem are the moving states (MS) and parallel track (PT) strategies, which have some serious shortcomings related to the above objectives. Motivated by these shortcomings, we first propose HybMig, which combines the merits of MS and PT and outperforms both in every aspect. As a second step, we extend PT, MS, and HybMig to the general problem of migration, where both the new and the old plans are treated as black boxes     

强调材料——清华大学核能技术研究院花园的再设计

1设计意识核能研究院花园再设计的项目证明了朱育帆在本设计中的一个偏好的原发点:材料意识和对材料精确性的把握。从这种材料意识出发,他的设计赋予了这个地点一种新的愉悦氛围,甚至是对当代中国风景园林境遇的一种注释。     

Conformal proton therapy for prostate carcinoma

The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both in vivo and in vitro. Here, we extend these observations by demonstrating the ability of nafenopin to suppress apoptosis induced by other major candidates for the signalling of cell death in the liver. Treatment of rat or mouse hepatocyte monolayers with TGFbeta1 or the DNA damaging drugs etoposide or hydroxyurea induced high levels of apoptosis. Western blot analysis did not support a role for either p53 or p21waf1 in etoposide-induced apoptosis in rat hepatocytes. Treatment of mouse hepatocytes with an agonistic anti-Fas antibody also resulted in an induction of high levels of apoptosis. Pre-addition and continued exposure to nafenopin suppressed apoptosis induced by all three stimuli. Overall, our studies demonstrate that the ability of nafenopin to protect hepatocytes from apoptosis is not restricted to species or apoptotic stimulus. It is possible, therefore, that the PPs may suppress apoptosis by acting on diverse signalling pathways. However, it seems more likely that nafenopin suppresses hepatocyte apoptosis elicited by each death stimulus by impinging on a core apoptotic mechanism.     

Digital repository: preservation environment and policy implementation

Distributed digital repositories can be used to address critical issues of long-term digital preservation and disaster management for large data centers. A policy-driven system provides an ideal solution for managing distributed repositories that require high flexibility and high configurability. Recent studies demonstrate that the integrated Rule-Oriented Data System, a peer-to-peer server middleware, provides the requisite dynamic extensibility needed to manage time-varying policies, automate validation of assessment criteria, manage ingestion processes, manage access policies, and manage preservation policies. The policy management can be implemented underneath existing digital library infrastructure such as Fedora.     

Templating of crystallization and shear-induced self-assembly of single-wall carbon nanotubes in a polymer-nanocomposite

We report the appearance of a novel self-assembling of a fraction of single-wall carbon nanotubes (SWCNT) within a SWCNT-polymer nanocomposite subjected to flow fields upon injection molding processing. By combining X-ray diffraction and Raman spectroscopy techniques, both working on a microfocus fashion, we probe that a fraction of the thinnest SWCNT self-assembles into a rectangular lattice in the sample regions where the shear stress induces the highest levels of nanotube aggregation. Additionally, we demonstrate that a modest amount in weight of nanotubes is enough to template the morphology of crystallization during flow providing a method to obtain a highly desirable fiber-like morphology.