Machine assignment and part-families formation using group technology

The conventional way of solving the group technology (GT) problem is to start from an assignment of parts to machines and try to find a partitioning of machine cells and part families. The similarity between parts is measured based on commonality of the machines assigned to them. However, parts are assigned to machines based on their operation requirements and the operation capabilities of machines. Similarity between parts should be based on their required operations. In this paper, the authors attempt to solve or facilitate solving the GT problem at the assignment level. An algorithm for assigning parts to machines is provided which utilizes the types of operations required by parts and applies GT principles in producing the assignment. This leads to better partitioning of machine cells and part-families. Furthermore, operation sequences required by parts in determining the similarity between parts have been considered. An algorithm to form part-families based on the operation sequence similarity coefficient has been developed. The resulting families are then used by the assignment algorithm to produce machine assignments to part-families. The use of the algorithm is demonstrated by examples.     

Depollution of atmospheric emissions of wood pyrolysis furnaces

The wood carbonization in Tunisia consists essentially of traditional activity using charcoaling stacks and pits characterized by high atmospheric pollution and poor energy conversion. Indeed, 70% of the initial mass of anhydrous wood are found in the vapor as aerosols, polluting and toxic gases and complex condensable organic compounds that can cause a substantial pollution of air, ground and water. Several processes of treatment and energy valorization of such effluents were proposed, but the incineration remains at present the most promising technique of depollution. The results show that the incineration, at about 1000°C, of wood carbonization smokes allows the destruction of 99% of the mass of pollutants except CO₂ and the reduction of polluting gas emission. The possible valorization of the smoke’s energy in the exit of the incinerator enhances the thermal efficiency of the process.     

A furostanol saponin from fruits of Balanites aegyptiaca

A new furostanol saponin was isolated from the mesocarp of Balanites aegyptiaca fruits and identified as 26-O-beta-D-glucopyranosyl-(25R)-furost-5-ene-3,22,26-triol 3-O-[[alpha-L-rhamnopyranosyl-(1-->2)]-[beta-D-xylopyranosyl-(1-->2)]-be ta- D-xylopyranosyl-(1-->2)]-beta-D-xylopyranoside (balanitesin).     

Influence of annealing on properties and structure of alumina

Alumina bodies were prepared from pure alumina powder (98.9% Al₂O₃ consisting of 82% > 53m). The powder was compacted by hot-pressing at 1200° C, Compacted bodies were annealed at 1300, 1400 and 1500° C. Annealing continued at each maximum temperature for 25, 50 and 100 h. Strong bodies were obtained with maximum bulk density of 2.32 g cm^–3 and minimum apparent porosity of 30.21%. The change in sintering parameters with annealing was correlated with developed structure.     

Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2

Mutations in the Na-K-2Cl co-transporter NKCC2 lead to type I Bartter syndrome, a life-threatening kidney disease. We previously showed that export from the ER constitutes the limiting step in NKCC2 maturation and cell surface expression. Yet, the molecular mechanisms involved in this process remain obscure. Here, we report the identification of chaperone stress 70 protein (STCH) and the stress-inducible heat shock protein 70 (Hsp70), as two novel binding partners of the ER-resident form of NKCC2. STCH knock-down increased total NKCC2 expression whereas Hsp70 knock-down or its inhibition by YM-01 had the opposite effect. Accordingly, overexpressing of STCH and Hsp70 exerted opposite actions on total protein abundance of NKCC2 and its folding mutants. Cycloheximide chase assay showed that in cells over-expressing STCH, NKCC2 stability and maturation are heavily impaired. In contrast to STCH, Hsp70 co-expression increased NKCC2 maturation. Interestingly, treatment by protein degradation inhibitors revealed that in addition to the proteasome, the ER associated degradation (ERAD) of NKCC2 mediated by STCH, involves also the ER-to-lysosome-associated degradation pathway. In summary, our data are consistent with STCH and Hsp70 having differential and antagonistic effects with regard to NKCC2 biogenesis. These findings may have an impact on our understanding and potential treatment of diseases related to aberrant NKCC2 trafficking and expression.     

Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities

Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5-tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual-acting drugs potentially useful in the protection of the heart against post-ischemic reperfusion injury. The pyrroline derivatives reported herein were found to be more potent as antiarrhythmic agents than mexiletine and displayed antioxidant activity. The most interesting tetramethylpyrroline congener, a tert-butyl-substituted analogue, was at least 100 times more active as an antiarrhythmic than mexiletine.     

Early-Life Development of the Bifidobacterial Community in the Infant Gut

The establishment of the gut microbiota poses implications for short and long-term health. Bifidobacterium is an important taxon in early life, being one of the most abundant genera in the infant intestinal microbiota and carrying out key functions for maintaining host-homeostasis. Recent metagenomic studies have shown that different factors, such as gestational age, delivery mode, or feeding habits, affect the gut microbiota establishment at high phylogenetic levels. However, their impact on the specific bifidobacterial populations is not yet well understood. Here we studied the impact of these factors on the different Bifidobacterium species and subspecies at both the quantitative and qualitative levels. Fecal samples were taken from 85 neonates at 2, 10, 30, 90 days of life, and the relative proportions of the different bifidobacterial populations were assessed by 16S rRNA–23S rRNA internal transcribed spacer (ITS) region sequencing. Absolute levels of the main species were determined by q-PCR. Our results showed that the bifidobacterial population establishment is affected by gestational age, delivery mode, and infant feeding, as it is evidenced by qualitative and quantitative changes. These data underline the need for understanding the impact of perinatal factors on the gut microbiota also at low taxonomic levels, especially in the case of relevant microbial populations such as Bifidobacterium. The data obtained provide indications for the selection of the species best suited for the development of bifidobacteria-based products for different groups of neonates and will help to develop rational strategies for favoring a healthy early microbiota development when this process is challenged.     

Creation of reactive centers on cotton. IV. Reaction of acrylamidomethylated cotton with some sulfur compounds

The addition of mercaptoethanol and hydrogen sulfide to the pendent double bonds of acrylamidomethylated cotton (AMC) has been investigated. The interaction of acrylonitrile with the modified celluloses so obtained (substrate I and II) and with AMC treated with ammonium hydroxide (substrate III) in the presence of Ce(IV) is studied. Substrate I shows higher initial grafting yields. than AMC; the opposite holds true for the maximum graft yields. The graft yields obtained with substrate II are lower than those of AMC. All modified cottons studied are less amenable to grafting compared with the unmodified cotton. The graft yields of AMC and substrate III are comparable due to the fact that both substrates are crosslinked. Probable reasons for the inferior reactivity of substrates I and II are also given.