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排序方式: 共有235条查询结果,搜索用时 46 毫秒
1.
In this paper we compare the dynamics on the centre manifold of the solutions of an ill-posed Boussinesq equation with a well-posed version. We show that the dynamics in the centre manifold of the ill-posed equation tracks the dynamics of the well-posed equation. Our results give partial justification to the long-wave perturbation theory. 相似文献
2.
Lucia Garcia-Garcia Laia Olle Margarita Martin Jordi Roca-Ferrer Rosa Muoz-Cano 《International journal of molecular sciences》2021,22(10)
Adenosine is a nucleoside involved in the pathogenesis of allergic diseases. Its effects are mediated through its binding to G protein-coupled receptors: A1, A2a, A2b and A3. The receptors differ in the type of G protein they recruit, in the effect on adenylyl cyclase (AC) activity and the downstream signaling pathway triggered. Adenosine can produce both an enhancement and an inhibition of mast cell degranulation, indicating that adenosine effects on these receptors is controversial and remains to be clarified. Depending on the study model, A1, A2b, and A3 receptors have shown anti- or pro-inflammatory activity. However, most studies reported an anti-inflammatory activity of A2a receptor. The precise knowledge of the adenosine mechanism of action may allow to develop more efficient therapies for allergic diseases by using selective agonist and antagonist against specific receptor subtypes. 相似文献
3.
Laia Lidn Laura Lla-Hierro Mario Nuvolone Adriano Aguzzi Jesús vila Isidro Ferrer Jos Antonio del Río Rosalina Gavín 《International journal of molecular sciences》2021,22(10)
Tau protein is largely responsible for tauopathies, including Alzheimer’s disease (AD), where it accumulates in the brain as insoluble aggregates. Tau mRNA is regulated by alternative splicing, and inclusion or exclusion of exon 10 gives rise to the 3R and 4R isoforms respectively, whose balance is physiologically regulated. In this sense, one of the several factors that regulate alternative splicing of tau is GSK3β, whose activity is inhibited by the cellular prion protein (PrPC), which has different physiological functions in neuroprotection and neuronal differentiation. Moreover, a relationship between PrPC and tau expression levels has been reported during AD evolution. For this reason, in this study we aimed to analyze the role of PrPC and the implication of GSK3β in the regulation of tau exon 10 alternative splicing. We used AD human samples and mouse models of PrPC ablation and tau overexpression. In addition, we used primary neuronal cultures to develop functional studies. Our results revealed a paralleled association between PrPC expression and tau 4R isoforms in all models analyzed. In this sense, reduction or ablation of PrPC levels induces an increase in tau 3R/4R balance. More relevantly, our data points to GSK3β activity downstream from PrPC in this phenomenon. Our results indicate that PrPC plays a role in tau exon 10 inclusion through the inhibitory capacity of GSK3β. 相似文献
4.
Timely run‐time software replacement techniques are a corner stone for reconciling real‐time systems development and dynamic behavior. Typical real‐time systems do not consider dynamic behavior because it deeply challenges predictability and timeliness. Current efforts are starting to merge the safe and predictable execution with a controllable level of dynamicity by imposing a set of bounds and limitations to the system dynamic behavior. One of the obstacles for this is how to time‐bound the different operations required to effectively implement component replacement. In this paper, the main challenges for this problem are identified, and a model to ensure that components can be replaced at run time preserving the temporal properties of the system is provided that also avoids failures in replacements. A real example and simulations of our replacement model are provided that validate the presented ideas. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
5.
David Sachez Montserrat Batet Aida Valls 《International Journal of Software and Informatics》2010,4(1):39-52
Computation of semantic similarity between concepts is a very common problem
in many language related tasks and knowledge domains. In the biomedical field, several approaches have been developed to deal with this issue by exploiting the structured knowledge
available in domain ontologies (such as SNOMED-CT or MeSH) and specific, closed and
reliable corpora (such as clinical data). However, in recent years, the enormous growth of
the Web has motivated researchers to start using it as the corpus to assist semantic analysis
of language. This paper proposes and evaluates the use of the Web as background corpus for
measuring the similarity of biomedical concepts. Several ontology-based similarity measures
have been studied and tested, using a benchmark composed by biomedical terms, comparing
the results obtained when applying them to the Web against approaches in which specific
clinical data were used. Results show that the similarity values obtained from the Web for
ontology-based measures are at least and even more reliable than those obtained from specific
clinical data, showing the suitability of the Web as information corpus for the biomedical
domain. 相似文献
6.
Nowadays, the use of Radio Frequency Identification (RFID) systems in industry and stores has increased. Nevertheless, some
of these systems present privacy problems that may discourage potential users. Hence, high confidence and effient privacy
protocols are urgently needed. Previous studies in the literature proposed schemes that are proven to be secure, but they
have scalability problems. A feasible and scalable protocol to guarantee privacy is presented in this paper. The proposed
protocol uses elliptic curve cryptography combined with a zero knowledge-based authentication scheme. An analysis to prove
the system secure, and even forward secure is also provided.
This work is supported by the Generalitat de Catalunya under Grant No. FIC 2007FIC 00880, and the projects of the Spanish
MCyT MTM2007-66842-C02-02 and TIN2006-15662-C02-02. 相似文献
7.
Ontology-driven web-based semantic similarity 总被引:1,自引:0,他引:1
David Sánchez Montserrat Batet Aida Valls Karina Gibert 《Journal of Intelligent Information Systems》2010,35(3):383-413
Estimation of the degree of semantic similarity/distance between concepts is a very common problem in research areas such
as natural language processing, knowledge acquisition, information retrieval or data mining. In the past, many similarity
measures have been proposed, exploiting explicit knowledge—such as the structure of a taxonomy—or implicit knowledge—such
as information distribution. In the former case, taxonomies and/or ontologies are used to introduce additional semantics;
in the latter case, frequencies of term appearances in a corpus are considered. Classical measures based on those premises
suffer from some problems: in the first case, their excessive dependency of the taxonomical/ontological structure; in the
second case, the lack of semantics of a pure statistical analysis of occurrences and/or the ambiguity of estimating concept
statistical distribution from term appearances. Measures based on Information Content (IC) of taxonomical concepts combine
both approaches. However, they heavily depend on a properly pre-tagged and disambiguated corpus according to the ontological
entities in order to compute accurate concept appearance probabilities. This limits the applicability of those measures to
other ontologies –like specific domain ontologies- and massive corpus –like the Web-. In this paper, several of the presented
issues are analyzed. Modifications of classical similarity measures are also proposed. They are based on a contextualized
and scalable version of IC computation in the Web by exploiting taxonomical knowledge. The goal is to avoid the measures’
dependency on the corpus pre-processing to achieve reliable results and minimize language ambiguity. Our proposals are able
to outperform classical approaches when using the Web for estimating concept probabilities. 相似文献
8.
Time series prediction is a complex problem that consists of forecasting the future behavior of a set of data with the only
information of the previous data. The main problem is the fact that most of the time series that represent real phenomena
include local behaviors that cannot be modelled by global approaches. This work presents a new procedure able to find predictable
local behaviors, and thus, attaining a better level of total prediction. This new method is based on a division of the input
space into Voronoi regions by means of Evolution Strategies. Our method has been tested using different time series domains.
One of them that represents the water demand in a water tank, through a long period of time. The other two domains are well
known examples of chaotic time series (Mackey-Glass) and natural phenomenon time series (Sunspot). Results prove that, in
most of cases, the proposed algorithm obtain better results than other algorithms commonly used. 相似文献
9.
Alvarez I Carrascal M Canals F Muixí L Abián J Jaraquemada D 《Proteomics. Clinical applications》2007,1(3):286-298
HLA class I molecules present peptides on the cell surface to CD8(+) T cells. The repertoire of peptides that associate to class I molecules represents the cellular proteome. Therefore, cells expressing different proteomes could generate different class I-associated peptide repertoires. A large number of peptides have been sequenced from HLA class I alleles, mostly from lymphoid cells. On the other hand, T cell immunotherapy is a goal in the fight against cancer, but the identification of T cell epitopes is a laborious task. Proteomic techniques allow the definition of putative T cell epitopes by the identification of HLA natural ligands in tumor cells. In this study, we have compared the HLA class I-associated peptide repertoire from the hepatocellular carcinoma (HCC) cell line SK-Hep-1 with that previously described from lymphoid cells. The analysis of the peptide pool confirmed that, as expected, the peptides from SK-Hep-1 derive from proteins localized in the same compartments as in lymphoid cells. Within this pool, we have identified 12 HLA class I peptides derived from HCC-related proteins. This confirms that tumor cell lines could be a good source of tumor associated antigens to be used, together with MS, to define putative epitopes for cytotoxic T cells from cancer patients. 相似文献
10.
David Sánchez Montserrat Batet David Isern Aida Valls 《Expert systems with applications》2012,39(9):7718-7728
Estimation of the semantic likeness between words is of great importance in many applications dealing with textual data such as natural language processing, knowledge acquisition and information retrieval. Semantic similarity measures exploit knowledge sources as the base to perform the estimations. In recent years, ontologies have grown in interest thanks to global initiatives such as the Semantic Web, offering an structured knowledge representation. Thanks to the possibilities that ontologies enable regarding semantic interpretation of terms many ontology-based similarity measures have been developed. According to the principle in which those measures base the similarity assessment and the way in which ontologies are exploited or complemented with other sources several families of measures can be identified. In this paper, we survey and classify most of the ontology-based approaches developed in order to evaluate their advantages and limitations and compare their expected performance both from theoretical and practical points of view. We also present a new ontology-based measure relying on the exploitation of taxonomical features. The evaluation and comparison of our approach’s results against those reported by related works under a common framework suggest that our measure provides a high accuracy without some of the limitations observed in other works. 相似文献