Frontolimbic Response to Negative Feedback in Clinical Depression.

Functional neuroimaging suggests that limbic regions of the medial frontal cortex may be abnormally active in individuals with depression. These regions, including the anterior cingulate cortex, are engaged in both action regulation, such as monitoring errors and conflict, and affect regulation, such as responding to pain. The authors examined whether clinically depressed subjects would show abnormal sensitivity of frontolimbic networks as they evaluated negative feedback. Depressed subjects and matched control subjects performed a video game in the laboratory as a 256-channel EEG was recorded. Speed of performance on each trial was graded with a feedback signal of A, C, or F. By 350 ms after the feedback signal, depressed subjects showed a larger medial frontal negativity for all feedback compared with control subjects with a particularly striking response to the F grade. This response was strongest for moderately depressed subjects and was attenuated for subjects who were more severely depressed. Localization analyses suggested that negative feedback engaged sources in the anterior cingulate and insular cortices. These results suggest that moderate depression may sensitize limbic networks to respond strongly to aversive events. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A revised method for ranking fuzzy numbers using maximizing set and minimizing set

A large number of methods have been proposed for ranking fuzzy numbers in the last few decades. Nevertheless, none of these methods can always guarantee a consistent result for every situation. Some of them are even non-intuitive and not discriminating. Chen proposed a ranking method in 1985 to overcome these limitations and simplify the computational procedure based on the criteria of total utility through maximizing set and minimizing set. However, there were some shortcomings associated with Chen’s ranking method. Therefore, we propose a revised ranking method that can overcome these shortcomings. Instead of considering just a single left and a single right utility in the total utility, the proposed method considers two left and two right utilities. In addition, the proposed method also takes into account the decision maker’s optimistic attitude of fuzzy numbers. Several comparative examples and an application demonstrating the usage, advantages, and applicability of the revised ranking method are presented. It can be concluded that the revised ranking method can effectively resolve the issues with Chen’s ranking method. Moreover, the revised ranking method can be used to differentiate different types of fuzzy numbers.     

Methodological approaches for histamine quantification using derivatization by chloroethylnitrosourea and ELISA measurement. Part II: Optimisation of the derivatization step

In a previous paper (part I), new strategy was used for raising antibodies against hapten (< 300 Da) and the quantification of these hapten by ELISA using derivatization by chloroethyl nitrosourea (CENU). After raising antibodies against histamine, they were characterized and used for ELISA measurements. Optimal detection conditions were determined for the histamine quantification by ELISA method. The present study investigates the derivatization step of the histamine by chloroethylnitrosourea (CENU). Five factors (2 qualitative: nature of the solvent and nature of the antibodies and 3 quantitative: pH, % of solvent and time of derivatization) have been considered. Optimal reaction conditions were established by calculation of a validated model.     

Ultrasound-modulated twin-fluid atomization of a liquid jet

A resonant liquid capillary wave theory which extends Taylor's dispersion relation to include the sheltering effect of liquid surface inclination caused by air flow is presented. The resulting dispersion curves are compared to new experimental results of how drop-size and size distributions vary with surface tension and air velocity in both airblast and ultrasound-modulated twin-fluid atomization of liquids with a constant kinematic viscosity of 2 cSt. Good agreements between the theoretical predictions of relative growth rates of the capillary waves and the experimental results of drop-size and size distributions led to the conclusion that Taylor-mode breakup of capillary waves plays a very important role in twin-fluid (airblast) atomization of a liquid jet. Thus, the ultrasound-modulated twin-fluid atomization not only verifies the capillary wave mechanism but also provides a means for controlling the drop-size and size distributions in twin-fluid atomization, which has a variety of applications in fuel combustion, spray drying, and spray coating.     

Hydrogen transport and environmental embrittlement effects in iron aluminides

Environmental embrittlement types of six iron aluminides have been systematically evaluated using electrochemical hydrogen permeation measurement, hydrogen microprint technique and tensile test in this study. The results of hydrogen permeation and microprint technique show that three - disordered solid solution structure of binary and ternary iron aluminides (Fe-10Al, Fe-18Al, and Fe-18Al-5Cr) have higher effective diffusivity and permeation rate than B2 ordered structure of binary and ternary iron aluminides (Fe-28Al, Fe-28Al-5Cr, and Fe-40Al). The tensile test of six iron aluminides in air, vacuum treatment and hydrogen precharged were analyzed and concluded. Three - disordered solid solution structure of iron aluminides suffer in hydrogen environment which are quite different embrittlement mechanisms from those B2 ordered structure of iron aluminides with serious tensile loss in air by moisture induced embrittlement.     

High-flexibility piezoelectric ribbon fiber fabrication through multi-material thermal drawing

In this study, an amorphous poly(vinylidene fluoride-hexafluoropropylene) (P(VDF-HFP)) copolymer with a high yield strain (approximately 18 %) is proposed as a cladding material for highly flexible and reliable piezoelectric ribbon fibers. Macro preforms are fabricated for thermal drawing (TD) processes, in which a poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) film is sandwiched between two electrically conductive composite sheets (carbon black (CB)/polypropylene (PP)). The piezoelectric device is cladded with the P(VDF-HFP) copolymer. The preform geometries and TD parameters are optimized to overcome the incompatibility of flow characteristics among P(VDF-HFP), P(VDF-TrFE), and CB/PP composite at the drawing temperature, yielding fibers of length more than 80 m through TD. After annealing and poling, the fiber produces approximately 5 V (peak-to-peak) under 2.5 % tensile strain and 0.5 V (peak-to-peak) under bending deformation, with a 5-mm radius of curvature. Furthermore, the piezoelectric fiber shows no severe degradation in the output voltage after 10000 cycles of bending deformation with 1-mm radius of curvature. The piezoelectric ribbon fiber developed herein has potential as a flexible tensile, pressure, or bending sensor fiber for wearable applications.

     

Numerical and experimental analysis of large passivation opening for solder joint reliability improvement of micro SMD packages

In this paper, using a recently developed solder fatigue model for wafer level-chip scale package (WL-CSP), we investigated the improvement on solder joint reliability for a 8-bump micro SMD package by enlarging the passivation layer opening at the solder–die interface. The motivation to enlarge the passivation opening is to reduce the severity of the stress concentration caused by the original design, and also to increase the contact area between the solder bump and aluminum bump pad. It was confirmed in the thermal shock test that with the new design, package fatigue life improved by more than 70%. To numerically predict this improvement represents a unique challenge to the modeling. This is because in order to capture the slightest geometrical difference on the order of a few microns between the two designs, the multiple-layer solder-die interface needs to be modeled using extremely fine mesh, while the overall dimensions of the package and the test board are on the order of millimeters. To bridge this tremendous gap in geometry, a single finite element model that incorporates all necessary geometrical details is deemed computationally prohibitive and impractical. In this paper, we applied a global–local modeling scheme that was also suggested by others [1, 2 and 3]. The global model contains the complete package with much simplified solder–die interface whereas the local model includes only one solder joint, but with detailed solder–die interface. Unlike most global–local models proposed by others, we included time-independent plasticity and temperature-dependent materials in the global model. This greatly improved model correlation accuracy with only moderate increase in run time. Energy-based solder fatigue model was used to correlate the inelastic strain energy with the package fatigue life. In an earlier study [4], we have found that Darveaux’s equations tended to be conservative when applied to the micro SMD, and hence new correlations based on curve-fitting the test data were derived. In this paper, we used the newly derived equation and achieved less than 20% error in N₅₀ life for both designs, which is on par with Darveaux’s equations when used for BGAs. The analysis also revealed two factors that may account for the life improvement. First, a slight decrease in inelastic energy dissipation after enlarging the passivation opening. Second, the shift of the crack initiation location which leads to longer crack growth length for the new design. The second factor was also independently confirmed by the failure analysis.