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排序方式: 共有1013条查询结果,搜索用时 375 毫秒
1.
Milena Jankovic Ivana Novakovic Dejan Nikolic Jasmina Mitrovic Maksic Slavko Brankovic Ivana Petronic Dragana Cirovic Sinisa Ducic Mirko Grajic Dragana Bogicevic 《International journal of molecular sciences》2021,22(9)
Diabetic neuropathy (DN), the most common chronic and progressive complication of diabetes mellitus (DM), strongly affects patients’ quality of life. DN could be present as peripheral, autonomous or, clinically also relevant, uremic neuropathy. The etiopathogenesis of DN is multifactorial, and genetic components play a role both in its occurrence and clinical course. A number of gene polymorphisms in candidate genes have been assessed as susceptibility factors for DN, and most of them are linked to mechanisms such as reactive oxygen species production, neurovascular impairments and modified protein glycosylation, as well as immunomodulation and inflammation. Different epigenomic mechanisms such as DNA methylation, histone modifications and non-coding RNA action have been studied in DN, which also underline the importance of “metabolic memory” in DN appearance and progression. In this review, we summarize most of the relevant data in the field of genetics and epigenomics of DN, hoping they will become significant for diagnosis, therapy and prevention of DN. 相似文献
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The ENTOREL Database for radiation stressed electronic components and systems has been established to collate data on high doses (aiming at Mega Grays) which meet the requirements of advanced teleoperators working in hazardous or disordered nuclear environments within the frame of a European telerobotics programme for the nuclear industry. The ENTOREL Database holds data from 614 tests on total dose effects 相似文献
4.
Niklas Schlimm Mirko Novakovic Robert Spielmann Tobias Knierim 《Informatik-Spektrum》2007,48(6):251-258
Nicht-funktionale Anforderungen an ein Softwaresystem beschreiben Aspekte, die nicht direkt die Funktionalit?t, wie sie der
Benutzer sieht, betreffen. 相似文献
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This article presents a longitudinal study of employment, unemployment and health of migrant workers in Germany. The analyses were conducted with longitudinal samples of the waves 1-6 (1984-1989) and the waves 6-9 (1989-1992) of the German Socio-Economic Panel (GSOEP). German and migrant workers did not respect to their health satisfaction but unemployed foreign workers were quite less satisfied with their health than unemployed Germans. This corresponded with a high percentage of foreign unemployed (30-50%) who felt chronically ill. A further examination of two (dichotomously formulated) principal investigation hypotheses could not show that the data support the explanation that the poorer health of unemployed migrants was caused by the unemployment situation. The results are interpreted in the way that the unemployed migrants' poorer health can be explained with (health) selection processes in the labour market. 相似文献
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Andrea Omicini Alessandro Ricci Mirko Viroli 《Electronic Notes in Theoretical Computer Science》2006,150(3):21-36
Human intelligence has evolved along with the use of more and more sophisticated tools, allowing Homo Faber (from Homo Habilis to Homo Sapiens Sapiens) to cope with environment changes, as well as to adapt the environment to his needs. Analogously, in this seminal paper we introduce the notion of Agens Faber, conveying the idea that agent intelligence should not be considered as separated by the agent ability to perceive and affect the environment—and so, that agent intelligence is strictly related to the artefacts that enable, mediate and govern any agent (intelligent) activity.
Along this line, we first discuss the notion of artefact for MAS in general, then we try to devise out the admissible / required / desirable features of an artefact for MAS. We elaborate on the many sorts of possible relations between agents and artefacts, focusing in particular on the issue of the rational exploitation of artefacts, and also rough out a possible taxonomy of artefacts for MAS. 相似文献
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John Seifert Angela Frelich Linda Shecterle John St Cyr 《Journal of the International Society of Sports Nutrition》2008,5(1):1-5
D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high- energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers. 相似文献