Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances

Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and (c) burst drug release which can be pharmacologically dangerous and economically inefficient. The present study brings a novel strategy for encapsulation and controlled release of PWSAS—caffeine in concentrations which are higher than its maximal water solubility without the possibility of burst effect. The modification of hydrophilic carrier based on poly(methacylic acid) was done using casein and liposomes. To further increase the maximal caffeine loading inside the carrier nicotinamide was used. The release study of the encapsulated PWSAS was elaborated with respect to morphology of the carriers and interactions that could be established between its structural components. The carriers swelling and the release of caffeine and nicotinamide were also investigated depending on caffeine concentration, the presence of different liposomal formulations and the volume ratio of liposomal formulation, in three media with different pH simulating the path of the carrier through the human gastrointestinal tract. The synthesized carriers are promising candidates for encapsulation of PWSAS in concentrations which are higher than its maximal water solubility and for the targeted delivery of those dosages.     

Volatile organic compound profiles of yoghurt produced from cow's milk with different somatic cell counts

The present study aimed to investigate the effect of somatic cell count (SCC) of raw cow's milk on the volatile organic compound (VOC) profiles of yoghurt. Test yoghurt samples were produced from three batches of cow's milk with low, medium and high SCC, respectively. The VOCs were determined by gas chromatography–mass spectrometry (GC–MS) analysis. A lower diacetyl and acetoin content and a higher content of 2‐heptanone, and butanoic and hexanoic acids were established in the yoghurt samples from batches with high SCC of above 1 000 000 cells/cm³. The increased SCC of cow's milk had a negative effect on the volatile organic compound profiles of yoghurt.     

Trends in registered psychiatric morbidity and forecasting psychotropic drug needs in Bulgarian hospitals

Registered psychiatric morbidity in Bulgaria as a whole and particularly in Plovdiv, the second largest region of the country, was assessed. Three aspects of psychotropic drug usage were analysed, namely, changes in registered psychotropic drugs, the prescribed daily dose (PDD) values for 2 years, and the preferred therapeutic schemes, and drug usage and needs in a psychiatric hospital with 365 beds. This was done by time series analysis for evaluation of psychiatric morbidity and drug consumption data, calculation of PDD for psychotropic medicines, and, based on a modification of the World Health Organization's morbidity method, assessment and prediction of drug use and needs in Plovdiv hospital. The results indicated that the registered morbidity had increased by 4% over the period 1989-93 to 2,427 psychiatric patients per 100,000 people. The increased consumption of especially benzodiazepines and sedative medicines was analyzed. Diazepam was prescribed the most often (91.1%), followed by levomepromazine (86.4%), haloperidol (82.7%), etc. Future drug consumption in Plovdiv hospital is expected to decrease because therapeutic practice in hospitals has been revised and improved on the basis of the World Health Organization's recommendations.     

Human-centered multimedia: culture, deployment, and access

Cultural setting is an intrinsic part of what we're trying to capture and use in muitimedia systems. However, being in our own culture (both everyday culture and professional culture) we forget that multimedia interfaces and communication are culture-specific. This article gives some great insights that stem from diversity in countries (and cultures) as well as inside the interdisciplinary multimedia community.     

Distribution of scientific productivity: Ambiguities in the assignment of author rank

Methodological implications of four accounting procedures applied in multiple authorship treatment relating to author productivity distribution were investigated. The emphasis was given to the individual author rank and inequality pattern of data. It was found that similar pattern of inequality holds in three of the four analysed cases, in spite of the fact that significant changes were observed on the individual level. By introducing the concept of dual approach a plausible interpretation of that phenomenon was obtained.Dedicated to the memory of Michael J. Moravcsik     

Dual approach to multiple authorship in the study of collaboration/scientific output relationship

This paper presents an empirical study of the relations between scientific output and collaboration performed on two scales: (1) an individual scale, for members of a study model, and (2) a group scale, for three samples varying in the level of productivity. The rank approach was applied in the preparation of the study model resulting in the selection of a set of the most prolific authors. In the course of that process, multiple authorship problem was solved by a dual approach, consisting of normal count and modified straight count procedures. As shown by the analysis of collaborative patterns, either on individual or on group scales, scientific output is highly dependent on the frequency of collaboration among the same authors. Expressed as the collaboration measure, it might serve as an indicator in comparative analyses of scientific productivity in a given field of science.     

Elimination kinetic model for organic chemicals in earthworms

Mechanistic understanding of bioaccumulation in different organisms and environments should take into account the influence of organism and chemical depending factors on the uptake and elimination kinetics of chemicals. Lipophilicity, metabolism, sorption (bioavailability) and biodegradation of chemicals are among the important factors that may significantly affect the bioaccumulation process in soil organisms. This study attempts to model elimination kinetics of organic chemicals in earthworms by accounting for the effects of both chemical and biological properties, including metabolism. The modeling approach that has been developed is based on the concept for simulating metabolism used in the BCF base-line model developed for predicting bioaccumulation in fish. Metabolism was explicitly accounted for by making use of the TIMES engine for simulation of metabolism and a set of principal transformations. Kinetic characteristics of transformations were estimated on the basis of observed kinetics data for the elimination of organic chemicals from earthworms.     

Conversion of Ethene to Propene by a Dual Function NiSO4/Re2O7/γ-Al2O3 Catalyst

A NiSO₄/Re₂O₇/γ-Al₂O₃ catalyst was prepared by co-impregnation using an aqueous solution of NiSO₄ and [NH₄][ReO₄], which catalyzes direct conversion of ethene to propene at mild reaction condition (323 K, 1 atm). Catalyst deactivation may be caused by coke formation. The two catalytic components appear to work independently of each other.     

Utilising laboratory experiments as a first step to introduce primary sludge hydrolysis in full-scale.

Laboratory experiments have been utilised as a tool to determine the possible yield of soluble COD and VFAs from settled influent and preprecipitated sludge at Klagshamn wastewater treatment plant and to determine the degradability of the organic matter. The release of ammonium and orthophosphate from the hydrolysed sludge has been estimated. It is possible to produce soluble organic matter of good quality from settled influent and preprecipitated sludge at Klagshamn WWTP. Denitrification rates of 3.1 mg NO3-N/(g VSS x h) were found for the hydrolysate in laboratory tests. Owing to the low phosphate concentrations in the hydrolysate from preprecipitated sludge, it shows a potential for postdenitrification despite stringent phosphorus outlet demands. Calculations based on data gained from the laboratory experiments show that about 50% of the external carbon source used today can be saved with minor changes in the plant operation except that the hydrolysis has to be established. Based on these findings, full-scale experiments with internal hydrolysis in the primary clarifiers were scheduled in one of the two lines at Klagshamn WWTP for the summer of 2007.