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1.
Resource scheduling in large-scale distributed systems, such as grids and clouds, is difficult due to the size, dynamism, and volatility of resources. These resources are eclectic and autonomous, and may exhibit different usage policies, levels of participation, capabilities, local load, and reliability. Moreover, applications are likely to exhibit various patterns and levels, and distributed resources may organize into various different overlay topologies for information and query dissemination. Researchers have proposed a wide variety of approaches and policies for mapping offered load onto resources and for solving the various component parts of the scheduling problem. However, production clouds and grids may be underutilized, and may not exhibit the load to effectively characterize all of the scheduling system inputs. The composition of large-scale systems is also changing, potentially to include more individual and peer-to-peer resources. These factors will influence the effectiveness of proposed scheduling solutions. Therefore, a simulation environment is necessary to study different approaches under different scenarios, especially those that are expected, but that are not currently characteristic of existing systems. This article describes a general-purpose peer-to-peer simulation environment that allows a wide variety of parameters, protocols, strategies and policies to be varied and studied. To provide a proof of concept, utilization of the simulation environment is presented in a large-scale distributed system problem that includes a core model and related mechanisms. In particular, this article presents a definition and possible peer-to-peer solutions for the large-scale scheduling problem. Moreover, this article describes a general simulation model, some policies that can be varied, an implementation, and some sample results.  相似文献   
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Multiscale modeling and integration of physiological models carry challenges due to the complex nature of physiological processes. High coupling within and among scales present a significant challenge in constructing and integrating multiscale physiological models. In order to deal with such challenges in a systematic way, there is a significant need for an information technology framework together with related analytical and computational tools that will facilitate integration of models and simulations of complex biological systems. Physiological Model Simulation, Integration and Modeling Framework (Phy-SIM) is an information technology framework providing the tools to facilitate development, integration and simulation of integrated models of human physiology. Phy-SIM brings software level solutions to the challenges raised by the complex nature of physiological systems. The aim of Phy-SIM, and this paper is to lay some foundation with the new approaches such as information flow and modular representation of the physiological models. The ultimate goal is to enhance the development of both the models and the integration approaches of multiscale physiological processes and thus this paper focuses on the design approaches that would achieve such a goal.  相似文献   
4.
Context-awareness becomes an increasingly important concept in the development of mobile and ubiquitous systems. Applications and services, which run in these kinds of highly dynamic environments, should be aware of and adapt to their contexts. Context-aware applications improve and enrich people’s interactions with devices, computers and other people.In this paper, design and development of iConAwa, which is an intelligent context-aware multi-agent system proactively providing mobile users with context-aware information and services, is described. In iConAwa, mobile users can get information and services about nearby resources (attraction points) according to their context and also communicate with each other by exchanging messages. Context and point of interest ontologies are developed in OWL. Context and points of interest are modelled in a flexible and extensible way by the developed ontology models. Knowledge sharing and knowledge reuse are also provided by using these ontology models. iConAwa makes use of rule-based context reasoning which provides derivation of high level implicit context from low level explicit context. With this approach context reasoning is decoupled from the source code of the system. JADE agent development framework is used to develop the agents and Jena semantic web framework is used to manipulate ontologies and for rule based reasoning.  相似文献   
5.
The effect of the micro- and nanotopography on vascular cell-surface interaction is investigated using nano- and microstructured Al2O3 as model substrate. Two different nanostructured Al2O3 surfaces composed of low density (LD) and high density (HD) nanowires (NWs) were synthesized by chemical vapour deposition (CVD) and commercially available microstructured Al2O3 plates were used for comparison. A clear diverging response of human umbilical vein endothelial cells (HUVEC) and human umbilical vein smooth muscle cells (HUVSMC) was observed on these nano- and microstructured surfaces. LD Al2O3 NWs seem to enhance the proliferation of HUVECs selectively. This selective control of the cell-surface interaction by topography may represent a key issue for the future stent material design.  相似文献   
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The aim of this study is to investigate the metallurgical and mechanical properties of friction welded stainless steel-copper joints. One of the manufacturing methods used to produce parts made from different materials is the friction welding method. Application of classical welding techniques to such materials is difficult because of they have different thermal properties. Stainless steel-copper joints are inevitable for certain applications due to unique performances such as higher electric conductivity, heat conductivity, corrosion resistance, and mechanical properties. In the present study, austenitic stainless steel and copper parts were joined by friction welding. Tensile, fatigue, and notch-impact tests were applied to friction welded specimens, and the results were compared with those for the original materials. Microstructure, energy dispersive x-ray, and x-ray diffraction (XRD) analysis and hardness variations were conducted on the joints. Results showed that various intermetallic phases such as FeCu4 and Cu2NiZn occurred at the interface. It was found from the microstructure and XRD analysis that intermetallic phases formed in the interface which further caused a decrease in the strength of the joints. However, hardness of the copper increased slightly, whereas the hardness of steel decreases slightly on the horizontal distance from the center.  相似文献   
7.
In-stent restenosis is a common complication after stent surgery which leads to a dangerous wall narrowing of a blood vessel. Laser assisted patterning is one of the effective methods to modify the stent surface to control cell–surface interactions which play a major role in the restenosis. In this current study, 316LS stainless steel substrates are structured by focusing a femtosecond laser beam down to a spot size of 50 μm. By altering the laser induced spot density three distinct surfaces (low density (LD), medium density (MD) and high density (HD)) were prepared. While such surfaces are composed of primary microstructures, due to fast melting and re-solidification by ultra-short laser pulses, nanofeatures are also observed as secondary structures. Following a detailed surface characterization (chemical and physical properties of the surface), we used a well-established co-culture assay of human microvascular endothelial cells and human fibroblasts to check the cell compatibility of the prepared surfaces. The surfaces were analyzed in terms of cell adherence, proliferation, cell morphology and the differentiation of the fibroblast into the myofibroblast, which is a process indicating a general fibrotic shift within a certain tissue. It is observed that myofibroblast proliferation decreases significantly on laser treated samples in comparison to non-treated ones. On the other hand endothelial cell proliferation is not affected by the surface topography which is composed of micro- and nanostructures. Such surfaces may be used to modify stent surfaces for prevention or at least reduction of restenosis.  相似文献   
8.
Environmental concerns and limited resource of petroleum fuels have caused interests in the development of alternative fuels for internal combustion (IC) engines. For diesel engines, alcohols are receiving increasing attention because they are oxygenated and renewable fuels. Therefore, in this study, the effect of injection timing on the exhaust emissions of a single cylinder, naturally aspirated, four-stroke, direct injection diesel engine has been experimentally investigated by using methanol-blended diesel fuel from 0% to 15% with an increment of 5%. The tests were conducted for three different injection timings (15°, 20° and 25 °CA BTDC) at four different engine loads (5 Nm, 10 Nm, 15 Nm, 20 Nm) at 2200 rpm. The experimental test results showed that Bsfc, NOx and CO2 emissions increased as BTE, smoke opacity, CO and UHC emissions decreased with increasing amount of methanol in the fuel mixture. When compared the results to those of original injection timing, NOx and CO2 emissions decreased, smoke opacity, UHC and CO emissions increased for the retarded injection timing (15 °CA BTDC). On the other hand, with the advanced injection timing (25 °CA BTDC), decreasing smoke opacity, UHC and CO emissions diminished, and NOx and CO2 emissions boosted at all test conditions. In terms of Bsfc and BTE, retarded and advanced injection timings gave negative results for all fuel blends in all engine loads.  相似文献   
9.
Because of the global warming impact of hydro fluorocarbons, the uses of natural refrigerants in automotive and HVAC industries have received worldwide attention. CO2 is the most promising refrigerant in these industries, especially the transcritical CO2 refrigeration cycle. The objective of this work is to identify the main factors that affect two‐stage compression transcritical CO2 system efficiency. A second law of thermodynamic analysis on the entire two‐stage CO2 cycle is conducted so that the exergy destruction of each system component can be deduced and ranked, allowing future efforts to focus on improving the components that have the highest potential for advancement. The inter‐stage pressure is used as a variable parameter in the analysis study. The second law efficiency, coefficient of cooling performance and total exergy destruction of the system variations with the inter‐stage pressure are presented graphically. It was concluded that there is an optimum inter‐stage pressure that maximizes both first law and second law efficiencies. Copyright © 2008 John Wiley & Sons, Ltd.  相似文献   
10.
Cenk Sayin  Mustafa Canakci 《Fuel》2010,89(7):1407-1414
In this study, the effects of injection pressure and timing on the performance and emission characteristics of a DI diesel engine using methanol (5%, 10% and 15%) blended-diesel fuel were investigated. The tests were conducted on three different injection pressures (180, 200 and 220 bar) and timings (15°, 20°, and 25° CA BTDC) at 20 Nm engine load and 2200 rpm. The results indicated that brake specific fuel consumption (BSFC), brake specific energy consumption (BSEC), and nitrogen oxides (NOx) emissions increased as brake thermal efficiency (BTE), smoke opacity, carbon monoxide (CO) and total unburned hydrocarbon (THC) decreased with increasing amount of methanol in the fuel mixture. The best results were achieved for BSFC, BSEC and BTE at the original injection pressure and timing. For the all test fuels, the increasing injection pressure and timing caused to decrease in the smoke opacity, CO, THC emissions while NOx emissions increase.  相似文献   
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