Coupling the folding of homologous proteins

The empirical observation that homologous proteins fold to similar structures is used to enhance the capabilities of an ab initio algorithm to predict protein conformations. A penalty function that forces homologous proteins to look alike is added to the potential and is employed in the coupled energy optimization of several homologous proteins. Significant improvement in the quality of the computed structures (as compared with the computational folding of a single protein) is demonstrated and discussed.     

Connecting the dots: Understanding the interrelated impacts of type,quality and children's awareness of design features and the mathematics content learning goals in digital math games and related learning outcomes

This study focused on an examination of how type, quality and children's awareness of design features in digital math games, along with an awareness of the mathematics goals of the game, were related to learning outcomes. We conducted a parallel conversion mixed methods study with 45 students in Grades 3 and 4 (ages 9–10). Students participated in clinical interviews using three digital math games. The results suggest a moderated mediation relationship in which the quality of the design features moderated the mediating impact of children's awareness of the game's design features, specifically when the child was aware of the mathematics content learning goal (MCLG) of the game. These findings show how important it is that design features are of high quality in a digital math game, and how this is intertwined with children's awareness of the features and the MCLG. When these variables intertwined in just the right way, the interactions between the children and the digital math game afforded mathematical learning growth.     

Flow modelling within non-homogeneous packings: The structural macro-correlations

The pressure drop and the fluid velocity profiles were investigated experimentally and numerically in the model packings of complex geometry. The numerical estimations were performed by means of the hybrid method involving the use of structural macro-correlations. In this paper it has been demonstrated on several examples that the structural macro-correlations allow to predict the macro-scale flow behaviour in non-homogeneous packings. Finally, the recent mechanistic approaches to flow modelling in packed tubes of low tube-to-particle diameter ratio have been discussed.     

Signal‐to‐noise ratios for measuring saliency of features extracted by eigenvector methods from ophthalmic arterial Doppler signals

Abstract: Features are used to represent patterns with minimal loss of important information. The feature vector, which is composed of the set of all features used to describe a pattern, is a reduced‐dimensional representation of that pattern. Medical diagnostic accuracies can be improved when the pattern is simplified through representation by important features. By identifying a set of salient features, the noise in a classification model can be reduced, resulting in more accurate classification. In this study, a signal‐to‐noise ratio saliency measure was employed to determine the saliency of input features of recurrent neural networks (RNNs) used in classification of ophthalmic arterial Doppler signals. Eigenvector methods were used to extract features representing the ophthalmic arterial Doppler signals. The RNNs used in the ophthalmic arterial Doppler signal classification were trained for the signal‐to‐noise ratio screening method. The application results of the signal‐to‐noise ratio screening method to the ophthalmic arterial Doppler signals demonstrated that classification accuracies of RNNs with salient input features are higher than those of RNNs with salient and non‐salient input features.     

Feature extraction by autoregressive spectral analysis using maximum likelihood estimation: internal carotid arterial Doppler signals

Abstract: In this study, Doppler signals recorded from the internal carotid artery (ICA) of 97 subjects were processed by personal computer using classical and model-based methods. Fast Fourier transform (classical method) and autoregressive (model-based method) methods were selected for processing the ICA Doppler signals. The parameters in the autoregressive method were found by using maximum likelihood estimation. The Doppler power spectra of the ICA Doppler signals were obtained by using these spectral analysis techniques. The variations in the shape of the Doppler spectra as a function of time were presented in the form of sonograms in order to obtain medical information. These Doppler spectra and sonograms were then used to compare the applied methods in terms of their frequency resolution and the effects in determination of stenosis and occlusion in the ICA. Reliable information on haemodynamic alterations in the ICA can be obtained by evaluation of these sonograms.     

A new mixed integer linear programming model for product development using quality function deployment

Quality function deployment (QFD) is a product development process performed to maximize customer satisfaction. In the QFD, the design requirements (DRs) affecting the product performance are primarily identified, and product performance is improved to optimize customer needs (CNs). For product development, determining the fulfillment levels of design requirements (DRs) is crucial during QFD optimization. However, in real world applications, the values of DRs are often discrete instead of continuous. To the best of our knowledge, there is no mixed integer linear programming (MILP) model in which the discrete DRs values are considered. Therefore, in this paper, a new QFD optimization approach combining MILP model and Kano model is suggested to acquire the optimized solution from a limited number of alternative DRs, the values of which can be discrete. The proposed model can be used not only to optimize the product development but also in other applications of QFD such as quality management, planning, design, engineering and decision-making, on the condition that DR values are discrete. Additionally, the problem of lack of solutions in integer and linear programming in the QFD optimization is overcome. Finally, the model is illustrated through an example.     

Automatic detection of electroencephalographic changes using adaptive neuro-fuzzy inference system employing Lyapunov exponents

This paper describes the application of adaptive neuro-fuzzy inference system (ANFIS) model for automatic detection of electroencephalographic changes. Decision making was performed in two stages: feature extraction by computation of Lyapunov exponents and classification by the ANFIS trained with the backpropagation gradient descent method in combination with the least squares method. Five types of electroencephalogram (EEG) signals were classified by five ANFIS classifiers. To improve diagnostic accuracy, the sixth ANFIS classifier (combining ANFIS) was trained using the outputs of the five ANFIS classifiers as input data. The proposed ANFIS model combined the neural network adaptive capabilities and the fuzzy logic qualitative approach. Some conclusions concerning the saliency of features on classification of the EEG signals were obtained through analysis of the ANFIS. The performance of the ANFIS model was evaluated in terms of training performance and classification accuracies and the results confirmed that the proposed ANFIS model has potential in classifying the EEG signals.     

Disassembly Sequencing Using Tabu Search

End-of-life disassembly has developed into a major research area within the sustainability paradigm, resulting in the emergence of several algorithms and structures proposing heuristics techniques such as Genetic Algorithm (GA), Ant Colony Optimization (ACO) and Neural Networks (NN). The performance of the proposed methodologies heavily depends on the accuracy and the flexibility of the algorithms to accommodate several factors such as preserving the precedence relationships during disassembly while obtaining near- optimal and optimal solutions. This paper improves a previously proposed Genetic Algorithm model for disassembly sequencing by utilizing a faster metaheuristic algorithm, Tabu search, to obtain the optimal solution. The objectives of the proposed algorithm are to minimize (1) the traveled distance by the robotic arm, (2) the number of disassembly method changes, and (3) the number of robotic arm travels by combining the identical-material components together and hence eliminating unnecessary disassembly operations. In addition to improving the quality of optimum sequence generation, a comprehensive statistical analysis comparing the previous Genetic Algorithm and the proposed Tabu Search Algorithm is also included