Effects of beta-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection

OBJECTIVES: The age-dependence of the development of ventricular arrhythmias was studied in German shepherd dogs with inherited ventricular arrhythmias and sudden death. BACKGROUND: A colony of German shepherd dogs has been established that exhibit inherited ventricular arrhythmias and sudden death. The incidence of arrhythmias increases with age. Because ventricular tachycardia is associated with bradycardia, it was hypothesized that the increased incidence of arrhythmias was related to age-dependent slowing of heart rate. METHODS: Arrhythmia counts and RR intervals were measured from serial ambulatory ECG recordings obtained in 71 dogs (1-48 weeks). In addition, 19 dogs were challenged with phenylephrine (10 micrograms/kg i.v.) at 15, 28, and 45 weeks of age, 10 dogs were challenged with epinephrine (1 microgram/kg i.v.) at 3, 5, 7, 9, 11, 18, and 28 weeks of age, and 10 dogs were challenged at 28 weeks with epinephrine (2.5 micrograms/kg i.v.), before and after propranolol (0.5 mg/kg i.v.). RESULTS: The incidence and severity of ventricular arrhythmias increased between 7 and 28 weeks of age and decreased between 28 and 44 weeks of age. The age-dependent increase in the incidence of ventricular tachycardia was associated with age-dependent reductions in sinus rate. Baroreflex-mediated slowing of the heart rate unmasked arrhythmias in young animals that did not spontaneously display arrthythmias and exacerbated existing arrhythmias in older animals. However, the magnitude of baroreflex-induced bradycardia was similar from 7-18 weeks of age, yet the incidence of arrhythmias increased progressively. Moreover, the waning of ventricular arrhythmias in older animals was not associated with more rapid sinus rates. CONCLUSION: The risk for sudden death in dogs with inherited ventricular arrhythmias increases with age in part because of age-dependent slowing of heart rate and in part because of other heart-rate-independent factors. The correspondence between the development of ventricular tachycardia and sinus pauses is consistent with the hypothesis that ventricular arrhythmias are initiated by early afterdepolarization-induced triggered activity.     

Improving the quality of shortwave broadcast reception indoors byusing an anti-fading probe antenna

When shortwave (SW) broadcasts are received on self-contained receivers indoors, there generally is a reduction in signal strength and an increase in the speed and depth of fading in comparison with reception in open spaces outdoors. Even when the received signal level is adequate, the quality of reception indoors is degraded. This comes about because the fields indoors are a superposition of components of radiated signal from the distant transmitter plus other components representing energy reradiated or scattered by nearby conductors such as house wiring or plumbing. Since many of the near-field components originate very close to the receiver, it is possible to reduce their effect by deriving the receiver input from two or more probes-i.e., pickup devices specially designed to respond to fields in their immediate vicinity without disturbing those fields. To achieve the desired probe action, advantage can be taken of the high input impedance of portable, battery-powered receivers designed for use with small telescoping whip antennas. Spacing of multiple probes in the order of a few tens of centimeters suffices to give an output significantly smoother and of higher quality than that obtainable with the receiver's whip antenna by itself. The high signal levels of many SW broadcasts make it practical to use small, inefficient antennas. This article describes an Anti-Fading Probe Antenna (APA), which produces a worthwhile improvement in reception quality indoors. It is simple to build, requires no adjustment, and may even improve received signal quality in some outdoor situations     

Phase-insensitive all-optical transistors based on second-ordernonlinearities

We demonstrate and compare two phase-insensitive all-optical transistors (AOT's) based on frequency-degenerate quadratic three-wave interactions. In particular, we demonstrate gain using KTP in a type II geometry. Both AOT's exploit the phase insensitivity inherent to three-wave parametric processes when only two fields are input, providing amplification of a small signal at the operating frequency via the interaction with a second-harmonic wave. The first scheme is based on successive up- and down-conversion (i.e., cascading) while the second relies on parametric down-conversion. We obtain gains of 5 and 160 in the two configurations, respectively, with a significant background and output coherent to the pump in the first case, no background and coherence between output and signal in the second     

Precision and accuracy of total body bone mass and body composition measurements in the rat using x-ray-based dual photon absorptiometry

Lean body mass (LBM), total body bone mineral mass (BMC), total body bone areal density (BMD), and body fat mass (FM) were measured in rats by dual photon absorptiometry (DXA), using two different instruments. The coefficients of variation for repeated measurements of LBM and FM were about 0.4 and 2.5%, respectively, over an animal body weight range of 150 to 600 g. For BMC and BMD, the coefficients of variation were less than 2%. The correlation coefficients for LBM, FM, BMC, and BMD measured on the two densitometers were all greater than 0.94. The slope of the regression line relating LBM measured by DXA and LBM measured by carcass analysis was 0.999, and the correlation coefficient was 0.99. For FM the slope was 1.05, and the correlation coefficient was 0.98. BMC measures by DXA were falsely low in small animals. For larger animals, the correlation between BMC and ash weight was 0.93, but the slope of the regression line was 0.78. DXA measures of LBM and FM were accurate and reproducible for rats weighing between 150 and 600 g. There was a size-dependent error in BMC, which will be significant in longitudinal measurements of bone mass.     

Spurious Valleys in the Error Surface of Recurrent Networks—Analysis and Avoidance

This paper gives a detailed analysis of the error surfaces of certain recurrent networks and explains some difficulties encountered in training recurrent networks. We show that these error surfaces contain many spurious valleys, and we analyze the mechanisms that cause the valleys to appear. We demonstrate that the principle mechanism can be understood through the analysis of the roots of random polynomials. This paper also provides suggestions for improvements in batch training procedures that can help avoid the difficulties caused by spurious valleys, thereby improving training speed and reliability.     

Measurement of the optical damage threshold in fused quartz

The damage thresholds of five different types of quartz glass used for the production of spectroscopic cuvettes for liquids were determined with single temporal and spatial mode nanosecond pulses at 532 nm. One of the glasses had a damage threshold of ?420 J/cm(2), which was more than twice that of the other glasses.     

Low energy laser initiation of single crystals of β-lead azide

Unfocused low energy Q-switched and non-Q-switched ruby laser irradiation of individual single crystals of-lead azide of size 40m×200m×10mm has been studied using high-speed photography. It was found that the initiation of fast reaction occurs at isolated sites which are probably defects and act as absorption centres in the dielectric which is otherwise transparent to the ruby wavelength of 694.3 nm. It has also been shown that it is the power and not the energy of the incident beam that controls the initiation under these low energy irradiation conditions. Finally, the variation of the time delay to initiation with the incident laser energy suggests a thermal mechanism of initiation.     

Spatio-temporal analysis of precipitable water vapour over northwest china utilizing MERSI/FY-3A products

Northwest China is considered as the arid and semi-arid temperate continental climate, where the precipitation is closely related to precipitable water vapour (PWV) content. In this paper, the Medium-Resolution Spectral Imager (MERSI) water vapour products were first used to study the spatial and temporal characteristics of water vapour over Northwest China, which were developed by the National Satellite Meteorological Center of China from the Chinese second-generation polar orbit Meteorological Satellite Fengyun 3A (FY-3A). In order to utilize the MERSI water vapour products, the MERSI 5 min water vapour product is compared respectively with global positioning system (GPS), Aerosol Robotic Network (AERONET) and Radiosonde water vapour data in situ datasets. The results show that the water vapour values of the MERSI product are a slightly lower than referenced data, and the accuracy of MERSI product compared with GPS water vapour is the most agreeable, with a mean absolute percentage error (MAPE) of 22.83%. The PWV content displays a typical spatial distribution pattern in Northwest China that it is the highest in the southeast, the second for the northwest and the lowest in the south-centre. The water vapour content over each province in a descending order is Shaanxi, Ningxia, west of Inner Mongolia, Xinjiang, Gansu and Qinghai. The seasonal variation of water vapour content over Northwest China appears to be lowest in winter, followed by spring, then for autumn, and highest in summer. The PWV content of each province in Northwest China shows the periodic inner-annual variation, that is, the PWV content is lowest in January, and gradually increases with time till it peaks in July, and then decreases monthly afterwards, which agrees with the quadratic polynomial model by months. The standard deviation of the water vapour content in summer is 0.533–1.027 mm, while that in winter is 0.262–0.527 mm.     

Nonlinear optical beam propagation for optical limiting

We implement numerical modeling of high-energy laser-pulse propagation through bulk nonlinear optical materials using focused beams. An executable program with a graphical user interface is made available to researchers for modeling the propagation of beams through materials much thicker than the diffraction length (up to 10(3) times longer). Ultrafast nonlinearities of the bound-electronic Kerr effect and two-photon absorption as well as time-dependent excited-state and thermal nonlinearities are taken into account. The hydrodynamic equations describing the rarefaction of the medium that is due to heating are solved to determine thermal index changes for nanosecond laser pulses. We also show how this effect can be simplified in some cases by an approximation that assumes instantaneous expansion (so-called thermal lensing approximation). Comparisons of numerical results with several Z-scan, optical limiting and beam distortion experiments are presented. Possible application to optimization of a passive optical limiter design is discussed.