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排序方式: 共有50条查询结果,搜索用时 19 毫秒
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Cover Picture: Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential (ChemMedChem 21/2016) 下载免费PDF全文
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Manel Rodríguez Ripoll Franz Heindl Christoph Lechner Vladimir Totolin Martin Jech Friedrich Bleicher 《摩擦学汇刊》2017,60(3):479-789
Machine hammer peening is a surface treatment technique originally developed for smoothening tools and mold surfaces. Treated surfaces are locally cold-worked, which results in a hardness increase and the induction of compressive residual stresses. In the present work, the feasibility of using this technique as a tool for embedding tungsten carbide hard particles on engineering-relevant substrate materials is systematically investigated. Tungsten carbide particles of three different sizes were embedded onto selected substrates using machine hammer peening. The particle embedment quality of the engineered surfaces was evaluated and correlated to the substrates' mechanical properties. The resulting tribological performance was investigated under reciprocating sliding conditions and the dominant wear mechanisms were correlated with the diameter of the embedded particles. The results show that machine hammer peening is a suitable technique for embedding hard particles in substrates of various materials, which additionally results in an enhancement in wear resistance, thus opening up a wide range of potential applications in tribologically loaded surfaces. 相似文献
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A measure of the facility with which plastic refractory material can be rammed into place as determined with a specified sand rammer has been designated “workability index” by the American Society for Testing Materials. In the method for determining the index, cognizance apparently has not been taken of numerous variables which may give a misleading value. Several of these variables have been investigated by the authors. As a result it is concluded that a determination of the work required with the sand rammer to produce maximum bulk density is a more reliable indicator of the suitability of a plastic for ramming purposes. 相似文献
6.
This is a progress report of an extensive study of fire clays and fireclay brick. It includes the results of a preliminary study of clays representative of those used in the manufacture of refractories throughout the United States. Chemical analyses and a summary of physical tests are given of both fire clays and the brick manufactured from them. The thermal expansion behavior of the fire clays fired at 1400°C and those of the fire brick “as received” from the manufacturer and also after firing at 1400°C, 1500°C, and 1600°C were studied and the materials classified into groups having characteristic thermal expansions. The moduli of elasticity and rupture were determined at 20°C, 550°C, and 1000°C. The resistance of the brick to spalling in a water-quenching test is expressed in an empirical relation correlating the elasticity, strength, coefficient of expansion, and percentage of grog used in compounding the brick batches. Data are presented on individual bricks made by the same manufacturer showing probable reasons for great differences in the number of quenchings required to cause spalling in the water-dip test. 相似文献
7.
Parameter Sweep Workflows for Modelling Carbohydrate Recognition 总被引:1,自引:0,他引:1
Tamas Kiss Pamela Greenwell Hans Heindl Gabor Terstyanszky Noam Weingarten 《Journal of Grid Computing》2010,8(4):587-601
Carbohydrate recognition is a phenomenon critical to a number of biological functions in humans. Understanding the dynamic
behaviour of oligosaccharides should help in the discovery of the mechanisms which lead to specific and selective recognition
of carbohydrates by proteins. Computer programs which can provide insight into such biological recognition processes have
significant potential to contribute to biomedical research if the results of the simulation can prove consistent with the
outcome of conventional wet laboratory experiments. In order to validate these simulation tools and support their wider uptake
by the bio-scientist research community, high-level easy to use integrated environments are required to run massively parallel
simulation workflows. This paper describes how the ProSim Science Gateway, based on the WS-PGRADE Grid portal, has been created
to execute and visualise the results of complex parameter sweep workflows for modelling carbohydrate recognition. 相似文献
8.
Analytic models based on discrete-time Markov chains (DTMC) are proposed to assess the algorithmic performance of Software Transactional Memory (TM) systems. Base STM variants are compared: optimistic STM with inplace memory updates and write buffering and pessimistic STM. Starting from an absorbing DTMC, closed-form analytic expressions are developed, which are quickly solved iteratively to determine key parameters of the considered STM systems, like the mean number of transaction restarts and the mean transaction length. Since the models reflect complex transactional behavior in terms of read/write locking, data consistency checks and conflict management independent of implementation details, they highlight the algorithmic performance advantages of one system over the other, which – due to their at times small differences – are often blurred by implementation of STM systems and even difficult to discern with statistically significant discrete-event simulations. 相似文献
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BACKGROUND: Inhibitory effects of volatile anaesthetics on platelet aggregation have been demonstrated in several studies. However, the influence of volatile anaesthetics on intracoronary platelet adhesion has not been elucidated so far. METHODS: Isolated hearts of guinea pigs were perfused with buffer in the absence or presence of volatile anaesthetics (0.5 and 1 MAC) at constant coronary flow rates of 5 ml/min for 25 min, then 1 ml/min for 30 min and again 5 ml/min for 10 min. Before, during and after low-flow perfusion, a bolus of human platelets was applied into the coronary system. To simulate thrombogenic conditions, 0.3 U/ml human thrombin was infused during low-flow perfusion and reperfusion. The number of platelets sequestered to the endothelium was calculated from the difference between coronary in- and output of platelets. The myocardial production of lactate and consumption of pyruvate and coronary perfusion pressure were also determined. RESULTS: At a flow rate of 5 ml/min only about 3% of the applied platelets did not emerge from the coronary system, in any group. In contrast, 13.1 +/- 1.2% (mean +/- SEM) of infused platelets became adherent in low-flow perfusion in the control group without anaesthetic. The adherence was reduced with each 1 MAC isoflurane (to 6.2 +/- 1.2%), sevoflurane (to 4.4 +/- 0.9%) or halothane (to 3.2 +/- 1.5%) (each P < 0.05 vs. control). Volatile anaesthetic, 0.5 MAC, did not inhibit platelet adhesion to a statistically significant extent in any case. Perfusion pressure and metabolic parameters were not statistically different between the control and the hearts exposed to anaesthetics. CONCLUSION: Volatile anaesthetics in a concentration of 1 MAC can reduce the adhesion of platelets in the coronary system under reduced flow conditions. This action does not arise from vasodilation or inhibition of ischaemic stress. 相似文献
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