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排序方式: 共有519条查询结果,搜索用时 15 毫秒
1.
Lili Chen Nanami Fujisawa Masato Takanohashi Mazaya Najmina Koichiro Uto Mitsuhiro Ebara 《International journal of molecular sciences》2021,22(5)
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery. 相似文献
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热压/热变形Nd2Fe14B/α-Fe纳米双相永磁体的研究 总被引:3,自引:0,他引:3
为了制备各向异性块状Nd2Fe14B/α—Fe纳米双相永磁体,研究了热压/热变形工艺参数与样品微观组织结构、磁性能之间的关系。结果表明,饱和磁化强度Js随模压温度的升高而提高;而剩磁Jr、内禀矫顽力Hcj和最大磁能积(BH)max开始都随模压温度的升高而上升,但超过一定温度后反而降低;同时提高热压压力会使磁性能增加,而热变形温度对磁性能影响很小。热变形后样品垂直于压力方向的磁性能略高于平行于压力方向,呈现出轻微的各向异性。Nd2Fe14B/α—Fe纳米双相永磁材料在热压/热变形后没有产生晶粒的择优长大,在晶体学上仍然是各向同性的。 相似文献
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We propose a novel noncontact sensing method for material identification and for detection of the distance between the sensor and the surface of a material by using its electrical and optical properties. In the proposed method, capacitance between the terminals of a pair of CdS cells, called the effective capacitance, is measured, and several capacitance values are obtained by changing the emission strength of the light emitting diode, thus changing the resistance value of the CdS cells. From these values, it is possible to identify the materials and to detect the distance between the CdS cells and the material. In this paper, we compare four kinds of effective capacitance measurement methods using a pair of CdS cells and describe the proposed measurement method. In addition, this paper discusses the measurement accuracy of effective capacitance values in the proposed method and demonstrates its ability to identify six material samples-clear, white, and black acrylic, clear vinyl chloride, brown bakelite, and aluminum-and to detect the distance between the CdS cells and the material. 相似文献
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O Motohashi M Suzuki N Shida K Umezawa T Ohtoh Y Sakurai T Yoshimoto 《Canadian Metallurgical Quarterly》1995,136(1-2):88-91
Subarachnoid haemorrhage (SAH) often leads to subarachnoid fibrosis and resultant normal pressure hydrocephalus; however, how subarachnoid fibrosis occurs is unknown. We examined the changes within arachnoid granulations (AGs) and the subarachnoid space (SAS) chronologically at the parasagittal region obtained from patients with SAH at autopsy and made comparison with controls by immunostaining for cytokeratin, specific marker for leptomeningeal cells and by the elastica Masson-Goldner methods. Within a week some AGs were torn, and many inflammatory cells filled the AGs and SAS. Cytokeratin positive cells were scarce. During the next two weeks cytokeratin positive cells increased. After three weeks, AGs and SAS were filled by dense deposits of extracellular matrices surrounded by multiple layers of leptomeningeal cells. 相似文献
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CdTe/GaAs是HgCdTe分子束外延的重要替代衬底材料。用X双晶衍射和光致发光测试研究了分子束外延生长的CdTe(211)B/GaAs(211)B的晶体结构质量,表明外延膜晶体结构完整,具有很高的质量。用高分辨率的透射电镜研究其界面特性,观察到CdTe(211)B相对于GaAs(211)B向着[111]方向倾斜一个小角度(约3°),界面的四面体键网发生扭曲,由于晶格失配,在界面存在很高的失配位错密度。用二次离子质谱分析仪分析了GaAs衬底中的Ga和As向CdTe外扩散的情况。结果表明:如果要在GaAs衬底上生长HgCdTe外延膜,必须先生长一层具有一定厚度的CdTe来阻止Ga和As向HgCdTe的外扩散和失配位错的延伸。 相似文献
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OBJECTIVES: To determine the prevalence of thyroid dysfunction in institutionalised elderly people in Cape Town and to assess the usefulness of an abnormal thyroid-stimulating hormone (TSH) concentration as a screening test in this group. DESIGN: Cross-sectional survey. SETTING: Four old-age homes in Cape Town. SUBJECTS: Old-age home residents aged 60 years and over. OUTCOME MEASURES: Serum concentrations of TSH, free thyroxine and free tri-iodothyronine. RESULTS: Serum TSH estimations were performed on 658 participants, and were abnormal in 103 (15.6%)-41 (6.2%) being elevated (> 5.0 microU/ml) and 62 (9.4%) being low (> 0.4 microU/ml). There were 3 newly diagnosed cases of hyperthyroidism and 7 of hypothyroidism. Subclinical disease was diagnosed in 40 subjects. The overall prevalence of thyroid dysfunction in this population was 11.2%. In 22 (3.4%) this had previously been recognised, while in 50 (7.8%) the dysfunction was newly diagnosed by the current survey. The positive predictive value of a TSH concentration > 20 microU/ml in predicting hypothyroidism is 67%, while it will predict 100% of cases of subclinical hypothyroidism. A TSH concentration < 0.1 microU/ml will predict 23% of cases of hyperthyroidism, but 81% of cases of subclinical disease. CONCLUSIONS: The prevalence of thyroid dysfunction in institutionalised elderly people in Cape Town is similar to that reported for elderly people in other centres. Thyroid dysfunction had not previously been recognised in approximately two-thirds of the subjects in this study. The serum TSH concentration is a reliable screening test for thyroid dysfunction in the elderly, but is less useful if used to identify biochemical thyroid disease. An elevated TSH concentration is a better predictor of thyroid dysfunction in the elderly than a depressed TSH concentration. 相似文献
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