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排序方式: 共有122条查询结果,搜索用时 782 毫秒
1.
Natsuhiko Kuratomi Shinichi Takano Mitsuharu Fukasawa Shinya Maekawa Makoto Kadokura Hiroko Shindo Ei Takahashi Sumio Hirose Yoshimitsu Fukasawa Satoshi Kawakami Hiroshi Hayakawa Hitomi Takada Natsuko Nakakuki Ryoh Kato Tatsuya Yamaguchi Yasuhiro Nakayama Hiromichi Kawaida Hiroshi Kono Taisuke Inoue Tetsuo Kondo Daisuke Ichikawa Nobuyuki Enomoto 《International journal of molecular sciences》2021,22(6)
New biomarkers are needed to further stratify the risk of malignancy in intraductal papillary mucinous neoplasm (IPMN). Although microRNAs (miRNAs) are expected to be stable biomarkers, they can vary owing to a lack of definite internal controls. To identify universal biomarkers for invasive IPMN, we performed miRNA sequencing using tumor-normal paired samples. A total of 19 resected tissues and 13 pancreatic juice samples from 32 IPMN patients were analyzed for miRNA expression by next-generation sequencing with a two-step normalization of miRNA sequence data. The miRNAs involved in IPMN associated with invasive carcinoma were identified from this tissue analysis and further verified with the pancreatic juice samples. From the tumor-normal paired tissue analysis of the expression levels of 2792 miRNAs, 20 upregulated and 17 downregulated miRNAs were identified. In IPMN associated with invasive carcinoma (INV), miR-10a-5p and miR-221-3p were upregulated and miR-148a-3p was downregulated when compared with noninvasive IPMN. When these findings were further validated with pancreatic juice samples, miR-10a-5p was found to be elevated in INV (p = 0.002). Therefore, three differentially expressed miRNAs were identified in tissues with INV, and the expression of miR-10a-5p was also elevated in pancreatic juice samples with INV. MiR-10a-5p is a promising additional biomarker for invasive IPMN. 相似文献
2.
Masayuki Kouno Ken Nakae Shigeyuki Oba Shin Ishii 《Artificial Life and Robotics》2013,17(3-4):417-425
In microscopic image processing for analyzing biological objects, structural characters of objects such as symmetry and orientation can be used as a prior knowledge to improve the results. In this study, we incorporated filamentous local structures of neurons into a statistical model of image patches and then devised an image processing method based on tensor factorization with image patch rotation. Tensor factorization enabled us to incorporate correlation structure between neighboring pixels, and patch rotation helped us obtain image bases that well reproduce filamentous structures of neurons. We applied the proposed model to a microscopic image and found significant improvement in image restoration performance over existing methods, even with smaller number of bases. 相似文献
3.
Joris Vaillant Abderrahmane Kheddar Hervé Audren François Keith Stanislas Brossette Adrien Escande Karim Bouyarmane Kenji Kaneko Mitsuharu Morisawa Pierre Gergondet Eiichi Yoshida Suuji Kajita Fumio Kanehiro 《Autonomous Robots》2016,40(3):561-580
We describe the research and the integration methods we developed to make the HRP-2 humanoid robot climb vertical industrial-norm ladders. We use our multi-contact planner and multi-objective closed-loop control formulated as a QP (quadratic program). First, a set of contacts to climb the ladder is planned off-line (automatically or by the user). These contacts are provided as an input for a finite state machine. The latter builds supplementary tasks that account for geometric uncertainties and specific grasps procedures to be added to the QP controller. The latter provides instant desired states in terms of joint accelerations and contact forces to be tracked by the embedded low-level motor controllers. Our trials revealed that hardware changes are necessary, and parts of software must be made more robust. Yet, we confirmed that HRP-2 has the kinematic and power capabilities to climb real industrial ladders, such as those found in nuclear power plants and large scale manufacturing factories (e.g. aircraft, shipyard) and construction sites. 相似文献
4.
5.
Takashi Tanaka Yosuke Matsuo Isao Kouno 《International journal of molecular sciences》2010,11(1):14-40
This review will discuss recent progress in the chemistry of secondary polyphenols produced during food processing. The production mechanism of the secondary polyphenols in black tea, whisky, cinnamon, and persimmon fruits will be introduced. In the process of black tea production, tea leaf catechins are enzymatically oxidized to yield a complex mixture of oxidation products, including theaflavins and thearubigins. Despite the importance of the beverage, most of the chemical constituents have not yet been confirmed due to the complexity of the mixture. However, the reaction mechanisms at the initial stages of catechin oxidation are explained by simple quinone–phenol coupling reactions. In vitro model experiments indicated the presence of interesting regio- and stereoselective reactions. Recent results on the reaction mechanisms will be introduced. During the aging of whisky in oak wood barrels, ellagitannins originating from oak wood are oxidized and react with ethanol to give characteristic secondary ellagitannins. The major part of the cinnamon procyanidins is polymerized by copolymerization with cinnamaldehyde. In addition, anthocyanidin structural units are generated in the polymer molecules by oxidation which accounts for the reddish coloration of the cinnamon extract. This reaction is related to the insolubilization of proanthocyanidins in persimmon fruits by condensation with acetaldehyde. In addition to oxidation, the reaction of polyphenols with aldehydes may be important in food processing. 相似文献
6.
Teruhiko Akazawa Hiroshi Ikeda Norihiko Ozawa Hideki Kouno Ryozo Yoshizaki 《Journal of Low Temperature Physics》1999,117(5-6):1235-1239
In order to investigate a relationship between the carrier concentration and negative magnetoresistance in the underdoped region, we have performed out-of-plane electrical resistivity measurements for underdoped Bi
2
Sr
1.6
La
0.4
CuO
6+
single crystals. Giant negative magnetoresistance has been observed in the most abundant carrier sample with = 0.12 in our experiment. The negative magnetoresistance reduces with decreasing carrier concentration. 相似文献
7.
On the basis of the mathematical notion of “micro-macro duality” for understanding mutual relations between microsopic quantum
systems (micro) and their macroscopic manifestations (macro) in terms of the notion of sectors and order parameters, a general
mathematical scheme is proposed for detecting the state-structure inside of a sector through measurement processes of a maximal
abelian subalgebra of the algebra of observables. For this purpose, the Kac-Takesaki operators controlling group duality play
essential roles, which naturally leads to the composite system of the observed system and the measuring system formulated
by a crossed product. This construction of composite systems will be shown to make it possible for the micro to be reconstructed
from its observational data as macro in the light of the Takesaki duality for crossed products. 相似文献
8.
Evert‐Jan van Donkelaar Juergen Schultze Toru Shibuya Yutaka Konai Mitsuharu Miyazaki 《Journal of the Society for Information Display》2002,10(3):223-229
In 1998, Toyo Gosei Co. published a paper on the development of a new water‐soluble photopolymer of high sensitivity, PVA‐ARBB. In close co‐operation with LG. Philips Displays, the new material was further developed to be applicable in patterning the phosphor layer of a CRT screen. The new material shows about 3 times higher light sensitivity, gives 4–5% higher luminance, has no dark reaction, and is chromium‐free. It is the first chromium‐free photoresist used for phosphor patterning in CRT mass production. A comparison is presented between the conventional resist and the new resist. A survey is given of the most important process conditions. 相似文献
9.
ABSTRACT Superheated steam drying of sintered spheres of glass beads with different diameters is investigated to reveal the effects of the gravitational force on drying rates. In a previous study, the drying rate curves of small samples with coarse glass beads in which the frictional resistance to flow of water and the effect of the gravitational force are negligible, were predicted by an evaporation zone model.In the present investigation, the drying rate curves of sintered spheres of glass beads with diameters ranging from 1.53×10-2m to 4.99×lO-2m are experimentally and theoretically obtained, and also the capillary pressure curves are measured by use of Haines' apparatus. The drying rate curves of large samples in which the effect of the gravitational force can not be negligible, are compared with those for small samples and the difference among these curves is discussed in terms of the moisture distributions which are estimated from the evaporation zone model with the observed capillary pressure curves. 相似文献
10.
Harushige Tsubakino Ryoichi Nozato Mitsuharu Hamamoto 《Journal of the American Ceramic Society》1991,74(2):440-443
The tetragonal-to-monoclinic martensitic phase transformation in ZrO–3 mol% Y2 O3 (PSZ) containing 0 to 12 wt% Al2 O3 was investigated by dilatometry, XRD, and SEM-EDS methods. The propagation of the transformation into the specimen interiors was suppressed by the addition of Al2 O3 . The grain size was independent of the addition of Al2 O3 . Both Y2 O3 and Al2 O3 segregated at grain boundaries. From this segregation behavior, it was suggested that a certain compound or phase of Y2 O3 –Al2 O3 could be formed at grain boundaries, which would presumably prevent the propagation of the transformation into interiors of PSZ-containing Al2 O3 . 相似文献