DYFRAM: dynamic fragmentation and replica management in distributed database systems

In distributed database systems, tables are frequently fragmented and replicated over a number of sites in order to reduce network communication costs. How to fragment, when to replicate and how to allocate the fragments to the sites are challenging problems that has previously been solved either by static fragmentation, replication and allocation, or based on a priori query analysis. Many emerging applications of distributed database systems generate very dynamic workloads with frequent changes in access patterns from different sites. In such contexts, continuous refragmentation and reallocation can significantly improve performance. In this paper we present DYFRAM, a decentralized approach for dynamic table fragmentation and allocation in distributed database systems based on observation of the access patterns of sites to tables. The approach performs fragmentation, replication, and reallocation based on recent access history, aiming at maximizing the number of local accesses compared to accesses from remote sites. We show through simulations and experiments on the DASCOSA distributed database system that the approach significantly reduces communication costs for typical access patterns, thus demonstrating the feasibility of our approach.     

Efficient search based on content similarity over self-organizing P2P networks

The advent of the World Wide Web has made an enormous amount of information available to everyone and the widespread use of digital equipment enables end-users (peers) to produce their own digital content. This vast amount of information requires scalable data management systems. Peer-to-peer (P2P) systems have so far been well established in several application areas, with file-sharing being the most prominent. The next challenge that needs to be addressed is (more complex) data sharing, management and query processing, thus facilitating the delivery of a wide spectrum of novel data-centric applications to the end-user, while providing high Quality-of-Service. In this paper, we propose a self-organizing P2P system that is capable to identify peers with similar content and intentionally assign them to the same super-peer. During content retrieval, fewer super-peers need to be contacted and therefore efficient similarity search is supported, in terms of reduced network traffic and contacted peers. Our approach increases the responsiveness and reliability of a P2P system and we demonstrate the advantages of our approach using large-scale simulations.     

Pan-Lysyl Oxidase Inhibitor PXS-5505 Ameliorates Multiple-Organ Fibrosis by Inhibiting Collagen Crosslinks in Rodent Models of Systemic Sclerosis

Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and subsequent build-up of fibrosis in the extracellular matrix. As such, their inhibition provides a novel treatment paradigm for SSc. A novel small molecule pan-lysyl oxidase inhibitor, PXS-5505, currently in clinical development for myelofibrosis treatment was evaluated using in vivo rodent models resembling the fibrotic conditions in SSc. Both lysyl oxidase and lysyl oxidase-like 2 (LOXL2) expression were elevated in the skin and lung of SSc patients. The oral application of PXS-5505 inhibited lysyl oxidase activity in the skin and LOXL2 activity in the lung. PXS-5505 exhibited anti-fibrotic effects in the SSc skin mouse model, reducing dermal thickness and α-smooth muscle actin. Similarly, in the bleomycin-induced mouse lung model, PXS-5505 reduced pulmonary fibrosis toward normal levels, mediated by its ability to normalise collagen/elastin crosslink formation. PXS-5505 also reduced fibrotic extent in models of the ischaemia-reperfusion heart, the unilateral ureteral obstruction kidney, and the CCl4-induced fibrotic liver. PXS-5505 consistently demonstrates potent anti-fibrotic efficacy in multiple models of organ fibrosis relevant to the pathogenesis of SSc, suggesting that it may be efficacious as a novel approach for treating SSc.     

Study on the Kinetics of Aluminum Removal from Liquid Silicon to Slag with Mechanical Stirring

Metallurgical and Materials Transactions B - The kinetics of aluminum removal from silicon melt to CaO-SiO2-Al2O3 slag was studied. A recently designed experimental setup using mechanical stirring...     

Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference

Decreased triacylglycerol synthesis within hepatocytes due to decreased diacylglycerol acyltransferase (DGAT) activity has been suggested to be an important mechanism by which diets rich in fish oil lower plasma triacylglycerol levels. New findings suggest that eicosapentaenoic acid (EPA), and not docosahexaenoic acid (DHA), lowers plasma triacylglycerol by increased mitochondrial fatty acid oxidation and decreased availability of fatty acids for triacylglycerol synthesis. To contribute to the understanding of the triacylglycerol-lowering mechanism of fish oil, the different metabolic properties of EPA and DHA were studied in rat liver parenchymal cells and isolated rat liver organelles. EPA-CoA was a poorer substrate than DHA-CoA for DGAT in isolated rat liver microsomes, and in the presence of EPA, a markedly lower value for the triacyl[³H]glycerol/diacyl[³H]glycerol ratio was observed. The distribution of [1-¹⁴C]palmitic acid was shifted from incorporation into secreted glycerolipids toward oxidation in the presence of EPA (but not DHA) in rat liver parenchymal cells. [1-¹⁴C]EPA was oxidized to a much greater extent than [1-¹⁴C]DHA in rat liver parenchymal cells, isolated peroxisomes, and especially in purified mitochondria. As the oxidation of EPA was more effective and sensitive to the CPT-I inhibitor, etomoxir, when measured in a combination of both mitochondria and peroxisomes, we hypothesized that both are involved in EPA oxidation, whereas DHA mainly is oxidized in peroxisomes. In rats, EPA treatment lowered plasma triacylglycerol and increased hepatic mitochondrial fatty acid oxidation and carnitine palmitoyltransferase (CPT)-I activity in both the presence and absence of malonyl-CoA. Whereas only EPA treatment increased the mRNA levels of CPT-I, DHA treatment increased the mRNA levels of peroxisomal fatty acyl-CoA oxidase and fatty acid binding protein more effectively than EPA treatment. In conclusion, EPA and DHA affect cellular organelles in relation to their substrate preference. The present study strongly supports the hypothesis that EPA, and not DHA, lowers plasma triacylglycerol by increased mitochondrial fatty acid oxidation.     

Dietary krill oil increases docosahexaenoic acid and reduces 2-arachidonoylglycerol but not N-acylethanolamine levels in the brain of obese Zucker rats

Evidence suggests that dietary long chain polyunsaturated fatty acids (LCPUFAs), and particularly those belonging to the n-3 family, may influence the brain fatty acid profile and, thereby, the biosynthesis of endocannabinoids in rodents. However, the doses used are usually quite high and not comparable with human intake. Recently, we have shown that relatively low doses of dietary n-3 LCPUFAs (4 weeks), in the form of either fish or krill oil, balanced for EPA and DHA content, and against a control diet with no EPA and DHA and similar contents of oleic, linoleic and α-linolenic acids, lower the concentrations of the endocannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), in the visceral adipose tissue, and of AEA in the liver and heart, of obese Zucker rats. This, in turn, is associated with lower levels of arachidonic acid in membrane phospholipids and with amelioration of some metabolic syndrome parameters. We investigated here whether in Zucker rats, under the same conditions, fish and krill oil are also able to influence LCPUFA and endocannabinoid profiles in brain. Only krill oil was able to increase significantly DHA levels in brain phospholipids, with no changes in arachidonic acid. DHA increase was associated with lower levels of 2-AG in the brain, whereas AEA and its congeners, N-palmitoylethanolamine and N-oleoylethanolamine, were unchanged. We conclude that, despite the strong impact of dietary n-3 fatty acid on endocannabinoid levels previously observed in peripheral tissues, in the brain only 2-AG is affected by dietary krill oil, suggesting that the beneficial effect of the latter on the metabolic syndrome is mostly exerted by modifying peripheral endocannabinoids. Nevertheless, possible effects of dietary krill oil in the brain through modification of 2-AG levels deserve further investigation.     

The significance of the North Atlantic Oscillation (NAO) for sea-salt episodes and acidification-related effects in Norwegian rivers

Acidification of Norwegian surface waters, as indicated by elevated concentrations of sulfate and a corresponding reduction in acid neutralizing capacity and pH, is a result of emission and subsequent deposition of sulfur and nitrogen compounds. Episodic sea-salt deposition during severe weather conditions may increase the effects of acidification by mobilizing more toxic aluminum during such episodes. Changes in climatic conditions may increase the frequency and strength of storms along the coast thus interacting with acidification effects on chemistry and biota. We found that the North Atlantic Oscillation (NAO) is linked to sea-salt deposition and sea-salt induced water chemistry effects in five rivers. Particularly, toxic levels of aluminum in all rivers were significantly correlated with higher NAO index values. Further, temporal trends were studied by comparing tendencies for selected statistical indices (i.e. frequency distributions) with time. The selected indices exhibited strong correlations between the NAO index, sea-salt deposition and river data such as chloride, pH and inorganic monomeric aluminum, pointing at the influence of North Atlantic climate variability on water chemistry and water toxicity. The potentially toxic effects of sea-salt deposition in rivers seem to be reduced as the acidification is reduced. This suggests that sea-salt episodes have to increase in strength in order to give the same potential negative biological effects in the future, if acid deposition is further reduced. More extreme winter precipitation events have been predicted in the northwest of Europe as a result of climate change. If this change will be associated with more severe sea-salt episodes is yet unknown.     

Radiation of water waves from an oscillating source located at a slope of angle π/4

An analytical investigation is performed of the linear radiation problem for water waves generated by an oscillating normal velocity distribution along a sloping beach with slope angle /4. The distribution of normal velocity is arbitrary, and it oscillates with a given frequency. The solution is expressed in terms of the Green function which represents a source of unit oscillatory flux located at an arbitrary position along the slope. At infinity the radiation condition is applied to determine the outgoing wave. As a simple example of integrating the Green function, the reflection of an incoming sinusoidal wave is calculated.     

Optimization of methods and treatment conditions for studying effects of fatty acids on cell growth

Antiproliferative properties of molecular regulators of lipid metabolism have been increasingly studied during recent years. Discussion is ongoing concerning optimal treatment conditions and assays used for monitoring proliferation and cytotoxicity. The objective of the present work was to optimize methods and treatment conditions used for studying antiproliferative effects of fatty acids and analogs, represented by palmitic acid (PA) and the β-oxidation-restricted fatty acid analog tetradecylthioacetic acid (TTA), in rat (BT4Cn) and human (D54Mg and GaMg) glioma cell lines. Changes in [³H]thymidine incorporation preceded changes in cell number in TTA-treated glioma cell cultures, and the growth inhibition was more significantly expressed by [³H]thymidine incorporation than cell number. Addition of bovine serum albumin decreased cellular fatty acid uptake and reduced the effects of TTA and PA on [³H]thymidine incorporation. Determination of the antiproliferative effect of TTA in BT4Cn cells by MTT conversion and [³H]thymidine incorporation yielded concordant results. TTA-mediated reduction in cell number corresponded to reduction in cellular protein and total DNA content in BT4Cn cells. Reduced growth potential in TTA-treated multicellular D54Mg and GaMg spheroids supported the findings from monolayer cultures. In conclusion, cell density, treatment period, fatty acid administration, and methods for growth determination may profoundly influence the outcome of cell growth experiments. Thus, experimental conditions should be carefully controlled when performing cell growth experiments, and effects on cell growth should preferably be confirmed by different methods. Karl Johan Tronstad and Kjetil Berge contributed equally to this article.     

Context-based caching and routing for P2P web service discovery

In modern heterogeneous environments, such as mobile, pervasive and ad-hoc networks, architectures based on web services offer an attractive solution for effective communication and inter-operation. In such dynamic and rapidly evolving environments, efficient web service discovery is an important task. Usually this task is based on the input/output parameters or other functional attributes, however this does not guarantee the validity or successful utilization of retrieved web services. Instead, non-functional attributes, such as device power features, computational resources and connectivity status, that characterize the context of both service providers and consumers play an important role to the quality and usability of discovery results. In this paper we introduce context-awareness in web service discovery, enabling the provision of the most appropriate services at the right location and time. We focus on context-based caching and routing for improving web service discovery in a mobile peer-to-peer environment. We conducted a thorough experimental study, using our prototype implementation based on the JXTA framework, while simulations are employed for testing the scalability of the approach. We illustrate the advantages that this approach offers, both by evaluating the context-based cache performance and by comparing the efficiency of location-based routing to broadcast-based approaches. Recommended by: Zakaria Maamar